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Odontology
Published in: Odontology 2/2017

01-04-2017 | Short Communication

Inhibitory effect of alpha-mangostin on Candida biofilms

Authors: Ruchadaporn Kaomongkolgit, Kusuma Jamdee

Published in: Odontology | Issue 2/2017

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Abstract

The objective of this study was to determine the inhibitory effect of alpha-mangostin on Candida biofilms. Candida species including Candida albicans, Candida krusei, Candida tropicalis, and Candida glabrata were tested. Candida biofilms were formed in flat-bottomed 96-well microtiter plates. The metabolic activity of cells within biofilms was quantified using the XTT assay. The results demonstrated that alpha-mangostin showed a significant anti-biofilm effect on both developing biofilms and preformed biofilms of Candida species. It may be concluded that alpha-mangostin could be an anti-biofilm agent against Candida species. Further in vivo investigations are needed to uncover the therapeutic values of this medicinal plant.
Literature
1.
Williams DW, Kuriyama T, Silva S, Malic S, Lewis MA. Candida biofilms and oral candidosis: treatment and prevention. Periodontol 2000. 2011;55(1):250–65.CrossRefPubMed
2.
Sanchez-Vargas LO, Estrada-Barraza D, Pozos-Guillen AJ, Rivas-Caceres R. Biofilm formation by oral clinical isolates of Candida species. Arch Oral Biol. 2013;58(10):1318–26.CrossRefPubMed
3.
ten Cate JM, Klis FM, Pereira-Cenci T, Crielaard W, de Groot PW. Molecular and cellular mechanisms that lead to Candida biofilm formation. J Dent Res. 2009;88(2):105–15.CrossRefPubMed
4.
Niimi M, Firth NA, Cannon RD. Antifungal drug resistance of oral fungi. Odontology. 2010;98(1):15–25.CrossRefPubMed
5.
Rautemaa R, Ramage G. Oral candidosis-clinical challenges of a biofilm disease. Crit Rev Microbiol. 2011;37(4):328–36.CrossRefPubMed
6.
Negri M, Salci TP, Shinobu-Mesquita CS, Capoci IR, Svidzinski TI, Kioshima ES. Early state research on antifungal natural products. Molecules. 2014;19(3):2925–56.CrossRefPubMed
7.
Jindarat S. Xanthones from mangosteen (Garcinia mangostana): multi-targeting pharmacological properties. J Med Assoc Thai. 2014;97(Suppl 2):S196–201.PubMed
8.
Gopalakrishnan G, Banumathi B, Suresh G. Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives. J Nat Prod. 1997;60(5):519–24.CrossRefPubMed
9.
Kaomongkolgit R, Jamdee K, Chaisomboon N. Antifungal activity of alpha-mangostin against Candida albicans. J Oral Sci. 2009;51(3):401–6.CrossRefPubMed
10.
Yiemwattana I, Kaomongkolgit R. Alpha-mangostin suppresses IL-6 and IL-8 expression in P. gingivalis LPS-stimulated human gingival fibroblasts. Odontology. 2015;103(3):348–55.CrossRefPubMed
11.
Kaomongkolgit R. Alpha-mangostin suppresses MMP-2 and MMP-9 expression in head and neck squamous carcinoma cells. Odontology. 2013;101(2):227–32.CrossRefPubMed
12.
Taweechaisupapong S, Aiemsaard J, Chitropas P, Khunkiti W. Inhibitory effect of lemongrass oil and its major constituents on Candida biofilm and germ tube formation. S Afr J Bot. 2012;81:95–102.CrossRef
13.
Costa AC, Pereira CA, Freire F, Junqueira JC, Jorge AO. Methods for obtaining reliable and reproducible results in studies of Candida biofilms formed in vitro. Mycoses. 2013;56(6):614–22.CrossRefPubMed
14.
Al-Massarani SM, El Gamal AA, Al-Musayeib NM, Mothana RA, Basudan OA, Al-Rehaily AJ, et al. Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and α-mangostin, its major xanthone derivative. Molecules. 2013;18(9):10599–608.CrossRefPubMed
15.
Mohamed GA, Ibrahim SR, Shaaban MI, Ross SA. Mangostanaxanthones I and II, new xanthones from the pericarp of Garcinia mangostana. Fitoterapia. 2014;98:215–21.CrossRefPubMed
16.
Thein ZM, Samaranayake YH, Samaranayake LP. In vitro biofilm formation of Candida albicans and non-albicans Candida species under dynamic and anaerobic conditions. Arch Oral Biol. 2007;52(8):761–7.CrossRefPubMed
17.
Rossoni RD, Barbosa JO, Vilela SF, dos Santos JD, de Barros PP, Prata MC, et al. Competitive interactions between C. albicans, C. glabrata and C. krusei during biofilm formation and development of experimental candidiasis. PLoS One. 2015;10(7):e0131700.CrossRefPubMedPubMedCentral
18.
Obolskiy D, Pischel I, Siriwatanametanon N, Heinrich M. Garcinia mangostana L.: a phytochemical and pharmacological review. Phytother Res. 2009;23(8):1047–65.CrossRefPubMed
19.
Martins N, Barros L, Henriques M, Silva S, Ferreira I. Activity of phenolic compounds from plant origin against Candida species. Ind Crops Prod. 2015;74:648–70.CrossRef
20.
Torrungruang K, Chutimaworapan S. Effect of mangosteen pericarp extract on cell viability in human gingival fibroblasts. CU Dent J. 2006;29:75–82.
21.
Sampath D, Vijavaraghavan K. Cardioprotective effect of alpha-mangostin, a xanthone derivative from mangosteen on tissue defense system against isoproterenol-induced myocardial infarction in rats. J Biochem Mol Toxicol. 2007;21:336–9.CrossRef
22.
Rassameemasmaung S, Sirikulsathean A, Amornchat C, Hirunrat K, Rojanapanthu P, Gritsanapan W. Effects of herbal mouthwash containing the pericarp extract of Garcinia mangostana L on halitosis, plaque and papillary bleeding index. J Int Acad Periodontol. 2007;9:19–25.PubMed
Metadata
Title
Inhibitory effect of alpha-mangostin on Candida biofilms
Authors
Ruchadaporn Kaomongkolgit
Kusuma Jamdee
Publication date
01-04-2017
Publisher
Springer Japan
Published in
Odontology / Issue 2/2017
Print ISSN: 1618-1247
Electronic ISSN: 1618-1255
DOI
https://doi.org/10.1007/s10266-016-0256-3

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