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01-12-2007 | Preclinical Study

The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells

Authors: Bernd C. Schmid, Günther A. Rezniczek, Gerhild Fabjani, Toshiyuki Yoneda, Sepp Leodolter, Robert Zeillinger

Published in: Breast Cancer Research and Treatment | Issue 3/2007

Abstract

Cell migration is essential in many diverse processes ranging from embryonic development to wound healing and immune response. Cancer cells have recently been shown to utilize chemoattraction mechanisms mediated by chemokines and their respective receptors, e.g., the CXCL12/CXCR4 pathway normally found in leukocytes. Here we show that Slit2, a secreted protein signaling through the Roundabout (Robo) receptor as a chemorepellent in axon guidance and neuronal migration, acts as a potent chemoattractant for breast cancer cells. Comparing cell lines specifically metastasizing to either brain or bone, we found significant differences in their responses to CXCL12 and Slit2 treatments, suggesting a role for Slit/Robo signaling in brain metastasis.

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Title: The neuronal guidance cue Slit2 induces targeted migration and may play a role in brain metastasis of breast cancer cells
Authors: Bernd C. Schmid
Günther A. Rezniczek
Gerhild Fabjani
Toshiyuki Yoneda
Sepp Leodolter
Robert Zeillinger
Publication date: 01-12-2007
Publisher: Springer US
Published in: Breast Cancer Research and Treatment / Issue 3/2007
Print ISSN: 0167-6806
Electronic ISSN: 1573-7217
DOI: https://doi.org/10.1007/s10549-007-9504-0

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