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Tumor Biology
Published in: Tumor Biology 5/2016

01-05-2016 | Original Article

The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization

Authors: Changming Wang, Zunqi Hu, Zhenxin Zhu, Xin Zhang, Ziran Wei, Yu Zhang, Dali Hu, Qingping Cai

Published in: Tumor Biology | Issue 5/2016

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Abstract

Macrophages play crucial roles in promoting tumor development and progression. In the present study, we found that the mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) was efficient in inducing M1 macrophage polarization. PA-MSHA treatment increases expression of M1-related cytokines and promotes activation of murine peritoneal macrophages (MPM). Interestingly, PA-MSHA inhibits cell proliferation and migration and induces the apoptosis of gastric carcinoma cells. These effects of PA-MSHA on M1 polarization were associated with activation of NF-κB expression. Thus, inducing polarization of M1 by PA-MSHA may be one potential strategy for inhibiting gastric carcinoma progression in mice.
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Metadata
Title
The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization
Authors
Changming Wang
Zunqi Hu
Zhenxin Zhu
Xin Zhang
Ziran Wei
Yu Zhang
Dali Hu
Qingping Cai
Publication date
01-05-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 5/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4451-6

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