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BMC Geriatrics

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Open Access 01-12-2021 | Research

The longitudinal associations between change in physical activity and cognitive functioning in older adults with chronic illness (es)

Authors: Esmee Volders, Renate H. M. de Groot, Catherine A. W. Bolman, Lilian Lechner

Published in: BMC Geriatrics | Issue 1/2021

Abstract

Background

Regular physical activity (PA) is potentially beneficial for age-related cognitive decline. Although moderate-to-vigorous physical activity (MVPA) is mostly advised, older adults with chronic illnesses might benefit more from light physical activity (LPA), as they suffer from mobility problems, pain, and fatigue, limiting high-intensity PA. Therefore, the longitudinal association between change in LPA and MVPA and the change in cognitive functioning (CF) is investigated in older adults with chronic illnesses.

Methods

In total 432 older adults (mean age 73.7 [±6.1] years; 46.8% female) with at least one chronic illness participated in this longitudinal observational study. Longitudinal associations between accelerometer-assessed change in PA (LPA and MVPA) and change in CF, measured with an objective validated neuropsychological test battery, were tested with multivariate linear regressions.

Results

An increase in LPA between baseline and 6 months follow-up was significantly associated with improved short-term verbal memory and inhibition over the first 6 months. In addition, the change score in LPA over the first 6 months was predictive for the change score in short-term verbal memory over 12 months. Furthermore, an increase in MVPA between baseline and 6 months follow-up was significantly associated with a decrease in longer-term verbal memory scores over the same six-month period.

Conclusions

For older adults with chronic illnesses who may experience difficulties in being sufficiently active, an increase in LPA is probably more achievable than an increase in MVPA. In addition, an increase in LPA enhances CF more than an increase in MVPA does.

Trial registration

Netherlands Trial Register NL6005; Date of Registration 21-03-2017.

Available only for authorised users

Bárrios H, Narciso S, Guerreiro M, Maroco J, Logsdon R, de Mendonça A. Quality of life in patients with mild cognitive impairment. Aging Ment Health. 2013;17(3):287–92. https://doi.org/10.1080/13607863.2012.747083.CrossRefPubMed

Kim JS, Park E, An M. The cognitive impact of chronic diseases on functional capacity in community-dwelling adults. J Nurs Res. 2019;27(1):e3–8. https://doi.org/10.1097/jnr.0000000000000272.CrossRef

Gajewski PD, Falkenstein M. Physical activity and neurocognitive functioning in aging - a condensed updated review. Eur Rev Aging and Phys Act. 2016;13(1). https://doi.org/10.1186/s11556-016-0161-3.

Northey JM, Cherbuin N, Pumpa KL, Smee DJ, Rattray B. Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis. Br J Sports Med. 2018;52(3):154–60. https://doi.org/10.1136/bjsports-2016-096587.CrossRefPubMed

Macpherson H, Teo WP, Schneider LA, Smith AE. A life-long approach to physical activity for brain health. Front Aging Neurosci. 2017;9:147. https://doi.org/10.3389/fnagi.2017.00147.CrossRefPubMedPubMedCentral

Bullard T, Ji M, An R, Trinh L, MacKenzie M, Mullen SP. A systematic review and meta-analysis of adherence to physical activity interventions among three chronic conditions: Cancer, cardiovascular disease, and diabetes. BMC Public Health. 2019;19(1):636. https://doi.org/10.1186/s12889-019-6877-z.CrossRefPubMedPubMedCentral

Umegaki H, Makino T, Uemura K, Shimada H, Cheng XW, Kuzuya M. Objectively measured physical activity and cognitive function in urban-dwelling older adults. Geriatr Gerontol Int. 2018;18(6):922–8. https://doi.org/10.1111/ggi.13284.CrossRefPubMed

Johnson LG, Butson ML, Polman RC, Raj IS, Borkoles E, Scott D, et al. Light physical activity is positively associated with cognitive performance in older community dwelling adults. J Sci Med Sport. 2016;19(11):877–82. https://doi.org/10.1016/j.jsams.2016.02.002.CrossRefPubMed

Stubbs B, Chen LJ, Chang CY, Sun WJ, Ku PW. Accelerometer-assessed light physical activity is protective of future cognitive ability: a longitudinal study among community dwelling older adults. Exp Gerontol. 2017;91:104–9. https://doi.org/10.1016/j.exger.2017.03.003.CrossRefPubMed

10.

Skender S, Ose J, Chang-Claude J, Paskow M, Brühmann B, Siegel EM, et al. Accelerometry and physical activity questionnaires - a systematic review. BMC Public Health. 2016;16(1):515. https://doi.org/10.1186/s12889-016-3172-0.CrossRefPubMedPubMedCentral

11.

Piercy KL, Troiano RP, Ballard RM, Carlson SA, Fulton JE, Galuska DA, et al. The physical activity guidelines for Americans. JAMA. 2018;320(19):2020–8. https://doi.org/10.1001/jama.2018.14854.CrossRefPubMed

12.

Amagasa S, Machida M, Fukushima N, Kikuchi H, Takamiya T, Odagiri Y, et al. Is objectively measured light-intensity physical activity associated with health outcomes after adjustment for moderate-to-vigorous physical activity in adults? A systematic review. Int J Behav Nutr Phys Act. 2018;15(1):65. https://doi.org/10.1186/s12966-018-0695-z.CrossRefPubMedPubMedCentral

13.

Haskell WL, Lee IM, Pate RR, Powell KE, Blair SN, Franklin BA, et al. Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Circulation. 2007;116(9):1081–93. https://doi.org/10.1161/CIRCULATIONAHA.107.185649.CrossRefPubMed

14.

WHO guidelines on physical activity and sedentary behaviour. Geneva: World Health Organization; 2020.

15.

Warburton DER, Nicol CW, Bredin SSD. Health benefits of physical activity: the evidence. CMAJ. 2006;174(6):801–9. https://doi.org/10.1503/cmaj.051351.CrossRefPubMedPubMedCentral

16.

Füzéki E, Engeroff T, Banzer W. Health benefits of light-intensity physical activity: a systematic review of accelerometer data of the national health and nutrition examination survey (NHANES). Sports Med. 2017;47(9):1769–93. https://doi.org/10.1007/s40279-017-0724-0.CrossRefPubMed

17.

Logsdon RG, Hochhalter AK, Sharkey JR. From message to motivation: where the rubber meets the road. Gerontologist. 2009;49(S1):S108–11. https://doi.org/10.1093/geront/gnp074.CrossRefPubMed

18.

Colcombe S, Kramer AF. Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychol Sci. 2003;14(2):125–30. https://doi.org/10.1111/1467-9280.t01-1-01430.CrossRefPubMed

19.

Kirk-Sanchez NJ, McGough EL. Physical exercise and cognitive performance in the elderly: current perspectives. Clin Interv Aging. 2014;9:51–62. https://doi.org/10.2147/CIA.S39506.CrossRef

20.

Bherer L, Erickson KI, Liu-Ambrose T. A review of the effects of physical activity and exercise on cognitive and brain functions in older adults. J Aging Res. 2013;657508:1–8. https://doi.org/10.1155/2013/657508.CrossRef

21.

Kelly ME, Loughrey D, Lawlor BA, Robertson IH, Walsh C, Brennan S. The impact of exercise on the cognitive functioning of healthy older adults: a systematic review and meta-analysis. Ageing Res Rev. 2014;16:12–31. https://doi.org/10.1016/j.arr.2014.05.002.CrossRefPubMed

22.

Smith PJ, Blumenthal JA, Hoffman BM, Cooper H, Strauman TA, Welsh-Bohmer K, et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosom Med. 2010;72(3):239–52. https://doi.org/10.1097/PSY.0b013e3181d14633.CrossRefPubMedPubMedCentral

23.

Erickson KI, Hillman C, Stillman CM, Ballard RM, Bloodgood B, Conroy DE, et al. Physical activity, cognition, and brain outcomes: a review of the 2018 physical activity guidelines. Med Sci Sports and Exerc. 2019;51(6):1242–51. https://doi.org/10.1249/MSS.0000000000001936.CrossRef

24.

Snowden M, Steinman L, Mochan K, Grodstein F, Prohaska TR, Thurman DJ, et al. Effect of exercise on cognitive performance in community-dwelling older adults: review of intervention trials and recommendations for public health practice and research. J Am Geriatr Soc. 2011;59(4):704–16. https://doi.org/10.1111/j.1532-5415.2011.03323.x.

25.

Van Uffelen JGZ, Chin A, Paw MJM, Hopman-Rock M, Van Mechelen W. The effects of exercise on cognition in older adults with and without cognitive decline: a systematic review. Clin J Sport Med. 2008;18(6):486–500. https://doi.org/10.1097/JSM.0b013e3181845f0b.CrossRefPubMed

26.

Young J, Angevaren M, Rusted J, Tabet N. Aerobic exercise to improve cognitive function in older people without known cognitive impairment. Cochrane Database Syst Rev. 2015;(4):CD005381. https://doi.org/10.1002/14651858.CD005381.pub4.

27.

Frost NJ, Weinborn M, Gignac GE, Rainey-Smith SR, Markovic S, Gordon N, et al. A randomized controlled trial of high-intensity exercise and executive functioning in cognitively normal older adults. Am J Geriatr Psychiatry. 2021;29(2):129–40. https://doi.org/10.1016/j.jagp.2020.06.015.CrossRefPubMed

28.

Gomes-Osman J, Cabral DF, Morris TP, McInerney K, Cahalin LP, Rundek T, et al. Exercise for cognitive brain health in aging: a systematic review for an evaluation of dose. Neurol Clin Pract. 2018;8(3):257–65. https://doi.org/10.1212/CPJ.0000000000000460.CrossRefPubMedPubMedCentral

29.

Voelcker-Rehage C, Godde B, Staudinger UM. Cardiovascular and coordination training differentially improve cognitive performance and neural processing in older adults. Front Hum Neurosci. 2011;5:26. https://doi.org/10.3389/fnhum.2011.00026.CrossRefPubMedPubMedCentral

30.

Niemann C, Godde B, Staudinger UM, Voelcker-Rehage C. Exercise-induced changes in basal ganglia volume and cognition in older adults. Neuroscience. 2014;281:147–63. https://doi.org/10.1016/j.neuroscience.2014.09.033.CrossRefPubMed

31.

Fuller BG, Stewart Williams JA, Byles JE. Active living-the perception of older people with chronic conditions. Chronic Illn. 2010;6(4):294–305. https://doi.org/10.1177/1742395310377673.CrossRefPubMed

32.

Tak E, Kuiper R, Chorus A, Hopman-Rock M. Prevention of onset and progression of basic ADL disability by physical activity in community dwelling older adults: a meta-analysis. Ageing Res Rev. 2013;12(1):329–38. https://doi.org/10.1016/j.arr.2012.10.001.CrossRefPubMed

33.

Volders E, De Groot RHM, Coumans JMJ, Bolman CAW, Lechner L. A randomized controlled trial into the cognitive effects of a computer-tailored physical activity intervention in older adults with chronic disease(s). Eur Rev Aging Phys Act. 2021;18(1):1–15. https://doi.org/10.1186/s11556-021-00259-9.CrossRef

34.

Volders E, Bolman CAW, De Groot RHM, Verboon P, Lechner L. The effect of active plus, a computer-tailored physical activity intervention, on the physical activity of older adults with chronic illness (es)-a cluster randomized controlled trial. Int J Environ Res Public Health. 2020;17(7):2590. https://doi.org/10.3390/ijerph17072590.CrossRefPubMedCentral

35.

Thomas AG, Dennis A, Bandettini PA, Johansen-Berg H. The effects of aerobic activity on brain structure. Front Psychol. 2012;3:86. https://doi.org/10.3389/fpsyg.2012.00086.CrossRefPubMedPubMedCentral

36.

Murman DL. The impact of age on cognition. Semin Hear. 2015;36(3):111–21. https://doi.org/10.1055/s-0035-1555115.CrossRefPubMedPubMedCentral

37.

Van der Elst W, Van Boxtel MPJ, Van Breukelen GJP, Jolles J. Rey’s verbal learning test: normative data for 1855 healthy participants aged 24-81 years and the influence of age, sex, education, and mode of presentation. J Int Neuropsychol Soc. 2005;11(3):290–302. https://doi.org/10.1017/S1355617705050344.CrossRefPubMed

38.

Van Der Elst W, Van Boxtel M, Van Breukelen G, Jolles J. The letter digit substitution test: normative data for 1,858 healthy participants aged 24-81 from the Maastricht aging study (MAAS): influence of age, education, and sex. J Clin Exp Neuropsychol. 2006;28(6):998–1009. https://doi.org/10.1080/13803390591004428.CrossRefPubMed

39.

Miyake A, Friedman NP, Emerson MJ, Witzki AH, Howerter A, Wager TD. The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: a latent variable analysis. Cogn Psychol. 2000;41(1):49–100. https://doi.org/10.1006/cogp.1999.0734.CrossRefPubMed

40.

Volders E, Bolman CAW, De Groot RHM, Lechner L. The effect of active plus, a computer-tailored physical activity intervention, on cognitive functioning of elderly people with chronic illness (es) - study protocol for a randomized controlled trial. BMC Public Health. 2019;19(1):1197. https://doi.org/10.1186/s12889-019-7517-3.CrossRefPubMedPubMedCentral

41.

Drain SC. Inquisit 5. Seattle: Millisecond Software; 2016. Available from: https://www.millisecond.com

42.

De Jong R, Coles MGH, Logan GD, Gratton G. In search of the point of no return: the control of response processes. J Exp Psy Hum Percept Perform. 1990;16(1):164–82. https://doi.org/10.1037/0096-1523.16.1.164.CrossRef

43.

Tannock R, Schachar RJ, Carr RP, Chajczyk D, Logan GD. Effects of methylphenidate on inhibitory control in hyperactive children. J Abnorm Child Psychol. 1989;17(5):473–91. https://doi.org/10.1007/BF00916508.CrossRefPubMed

44.

Congdon E, Mumford JA, Cohen JR, Galvan A, Canli T, Poldrack RA. Measurement and reliability of response inhibition. Front Psychol. 2012;3(37). https://doi.org/10.3389/fpsyg.2012.00037.

45.

Gorman E, Hanson HM, Yang PH, Khan KM, Liu-Ambrose T, Ashe MC. Accelerometry analysis of physical activity and sedentary behavior in older adults: a systematic review and data analysis. Eur Rev Aging Phys Act. 2014;11(1):35–49. https://doi.org/10.1007/s11556-013-0132-x.CrossRefPubMed

46.

Migueles JH, Cadenas-Sanchez C, Ekelund U, Delisle Nyström C, Mora-Gonzalez J, Löf M, et al. Accelerometer data collection and processing criteria to assess physical activity and other outcomes: a systematic review and practical considerations. Sport Med. 2017;47(9):1821–45. https://doi.org/10.1007/s40279-017-0716-0.CrossRef

47.

Choi L, Ward SC, Schnelle JF, Buchowski MS. Assessment of wear/nonwear time classification algorithms for triaxial accelerometer. Med Sci Sports Exerc. 2012;44(10):2009–16. https://doi.org/10.1249/MSS.0b013e318258cb36.CrossRefPubMedPubMedCentral

48.

Sasaki JE, John D, Freedson PS. Validation and comparison of ActiGraph activity monitors. J Sci Med Sport. 2011;14(5):411–6. https://doi.org/10.1016/j.jsams.2011.04.003.CrossRefPubMed

49.

Aguilar-Farías N, Brown WJ, Peeters GMEE. ActiGraph GT3X+ cut-points for identifying sedentary behaviour in older adults in free-living environments. J Sci Med Sport. 2014;17(3):293–9. https://doi.org/10.1016/j.jsams.2013.07.002.CrossRefPubMed

50.

Rey A. L’examen clinique en psychologie, vol. 222. Oxford: Presses Universitaries De France; 1958.

51.

Reitan RM, Wolfson D. The Halstead-Reitan neuropsychological test battery: theory and clinical interpretation (2nd ed.). Tucson, AZ: neuropsychology press. Tucson: Neuropsychological Press; 1993.

52.

Corrigan JD, Hinkeldey NS. Relationships between parts a and B of the trail making test. J Clin Psychol. 1987;43(4):402–9. https://doi.org/10.1002/1097-4679(198707)43:4<402::AID-JCLP2270430411>3.0.CO;2-E.CrossRefPubMed

53.

Verbruggen F, Logan GD, Stevens MA. STOP-IT: windows executable software for the stop-signal paradigm. Behav Res Methods. 2008;40(2):479–83. https://doi.org/10.3758/BRM.40.2.479.CrossRefPubMed

54.

Lawrence LM, Singleton JF. What do we mean by older adult and physical activity? Reviewing the use of these terms in recent research. Act Adapt Aging. 2017;41(1):22–46. https://doi.org/10.1080/01924788.2016.1272391.CrossRef

55.

Depp CA, Jeste DV. Definitions and predictors of successful aging: a comprehensive review of larger quantitative studies. Am J Geriatr Psychiatry. 2006;14(1):6–20. https://doi.org/10.1097/01.JGP.0000192501.03069.bc.CrossRefPubMed

56.

Boekhout JM, Peels DA, Berendsen BAJ, Bolman CAW, Lechner L. An eHealth intervention to promote physical activity and social network of single, chronically impaired older adults: adaptation of an existing intervention using intervention mapping. JMIR Res Protoc. 2017;6(11):e230. https://doi.org/10.2196/resprot.8093.CrossRefPubMedPubMedCentral

57.

Twisk JWR. Applied multilevel analysis: a practical guide for medical researchers. Cambridge: Cambridge University Press; 2006. https://doi.org/10.1017/CBO9780511610806.CrossRef

58.

R Core Team. A language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2019. Available from: https://www.R-project.org

59.

Hamer M, Terrera GM, Demakakos P. Physical activity and trajectories in cognitive function: English longitudinal study of ageing. J Epidemiol Community Health. 2018;72(6):477–83. https://doi.org/10.1136/jech-2017-210228.CrossRefPubMed

60.

Lee S, Yuki A, Nishita Y, Tange C, Kim H, Kozakai R, et al. Research relationship between light-intensity physical activity and cognitive function in a community-dwelling elderly population-An 8-year longitudinal study. J Am Geriatr Soc. 2013;61(3):452–3. https://doi.org/10.1111/jgs.12119.CrossRefPubMed

61.

Zhu W, Wadley VG, Howard VJ, Hutto B, Blair SN, Hooker SP. Objectively measured physical activity and cognitive function in older adults. Med Sci Sports Exerc. 2017;49(1):47–53. https://doi.org/10.1249/MSS.0000000000001079.CrossRefPubMedPubMedCentral

62.

Sposito G, Neri AL, Yassuda MS. Cognitive performance and engagement in physical, social and intellectual activities in older adults: the FIBRA study. Dement Neuropsychol. 2015;9(3):270–8. https://doi.org/10.1590/1980-57642015DN93000010.CrossRefPubMedPubMedCentral

63.

Dause T, Kirby E. Aging gracefully: social engagement joins exercise and enrichment as a key lifestyle factor in resistance to age-related cognitive decline. Neural Regen Res. 2019;14(1):39–42. https://doi.org/10.4103/1673-5374.243698.CrossRefPubMedPubMedCentral

64.

Chao YP, Wu CW, Lin LJ, Lai CH, Wu HY, Hsu AL, et al. Cognitive load of exercise influences cognition and neuroplasticity of healthy elderly: An exploratory investigation. J Med Biol Eng. 2020;40(3):391–9. https://doi.org/10.1007/s40846-020-00522-x.CrossRef

65.

Van den Dool R. Deelname aan sport en bewegen door ouderen. Utrecht: Mulier Instituut; 2019.

66.

Ashe MC, Miller WC, Eng JJ, Noreau L. Older adults, chronic disease and leisure-time physical activity. Gerontology. 2009;55(1):64–72. https://doi.org/10.1159/000141518.CrossRefPubMed

67.

Vilela TC, Muller AP, Damiani AP, Macan TP, da Silva S, Canteiro PB, et al. Strength and aerobic exercises improve spatial memory in aging rats through stimulating distinct neuroplasticity mechanisms. Mol Neurobiol. 2017 Dec;54(10):7928–37. https://doi.org/10.1007/s12035-016-0272-x.CrossRefPubMed

68.

Farren L, Belza B, Allen P, Brolliar S, Brown DR, Cormier ML, et al. Mall walking program environments, features, and participants: a scoping review. Prev Chronic Dis. 2015;12:e129. https://doi.org/10.5888/pcd12.150027.CrossRefPubMedPubMedCentral

69.

Elsawy B, Higgins KE. Physical activity guidelines for older adults. Am Fam Physician. 2010 Jan 1;81(1):55–9.PubMed

70.

Arvidsson D, Fridolfsson J, Börjesson M. Measurement of physical activity in clinical practice using accelerometers. J Intern Med. 2019;286(2):137–53. https://doi.org/10.1111/joim.12908.CrossRefPubMed

71.

Shephard RJ. Limits to the measurement of habitual physical activity by questionnaires. Br J Sports Med. 2003;37(3):197–206. https://doi.org/10.1136/bjsm.37.3.197.CrossRefPubMedPubMedCentral

72.

CBS. StatLine - Bevolking; hoogstbehaald onderwijsniveau en onderwijsrichting. Available from: https://opendata.cbs.nl/statline/#/CBS/nl/dataset/82816ned/table?dl=8083 [cited 2020 Dec 10].

73.

CBS. StatLine - Leefstijl en (preventief) gezondheidsonderzoek; persoonskenmerken Available from: https://opendata.cbs.nl/statline/#/CBS/nl/dataset/83021NED/table?ts=1522312658353 [cited 2020 Feb 19].

74.

Volksgezondheidenzorg.info. Chronische ziekten en multimorbiditeit-Cijfers & Context-Huidige situatie. [Internet]. RIVM: Bilthoven. 2016 [cited 2019 Feb 5]. DOI: https://doi.org/10.1186/s12942-017-0097-5, 16, 1, 23.

75.

Young DR, Hivert MF, Alhassan S, Camhi SM, Ferguson JF, Katzmarzyk PT, et al. Sedentary behavior and cardiovascular morbidity and mortality: a science advisory from the American Heart Association. Circulation. 2016 Sep 27;134(13):e262–79. https://doi.org/10.1161/CIR.0000000000000440.CrossRefPubMed

76.

Chen SY, Feng Z, Yi X. A general introduction to adjustment for multiple comparisons. J Thorac Dis. 2017;9(6):1725–9. https://doi.org/10.21037/jtd.2017.05.34.CrossRefPubMedPubMedCentral

Title: The longitudinal associations between change in physical activity and cognitive functioning in older adults with chronic illness (es)
Authors: Esmee Volders
Renate H. M. de Groot
Catherine A. W. Bolman
Lilian Lechner
Publication date: 01-12-2021
Publisher: BioMed Central
Published in: BMC Geriatrics / Issue 1/2021
Electronic ISSN: 1471-2318
DOI: https://doi.org/10.1186/s12877-021-02429-x

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