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Tumor Biology
Published in: Tumor Biology 9/2016

01-09-2016 | Original Article

The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinoma

Authors: Yaoyong Lu, Tao Li, Ganbao Wei, Liangbo Liu, Qinsheng Chen, Lufei Xu, Kunqiang Zhang, Dehao Zeng, Rongwei Liao

Published in: Tumor Biology | Issue 9/2016

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Abstract

Long non-coding RNAs (lncRNAs) play a critical role in cancer progression, including in nasopharyngeal carcinoma (NPC). However, it is still poorly understood whether lncRNA regulates epithelial to mesenchymal transition (EMT) and radioresistance of NPC cells. We found that lncRNA NEAT1 was significantly upregulated in NPC cell lines and tissues. Knockdown of NEAT1 could sensitize NPC cells to radiation in vitro. Further investigation found that NEAT1 regulated radioresistance by modulating EMT phenotype. Furthermore, we found that there was reciprocal repression between NEAT1 and miR-204. ZEB1 was identified as a downstream target of miR-204 and NEAT1 upregulated ZEB1 expression by negatively regulating miR-204 expression. Taking together, we proposed that NEAT1 regulated EMT phenotype and radioresistance by modulating the miR-204/ZEB1 axis in NPC.
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Metadata
Title
The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinoma
Authors
Yaoyong Lu
Tao Li
Ganbao Wei
Liangbo Liu
Qinsheng Chen
Lufei Xu
Kunqiang Zhang
Dehao Zeng
Rongwei Liao
Publication date
01-09-2016
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 9/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4773-4

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