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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2006

Open Access 01-12-2006 | Research article

The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

Authors: Wai Po Chong, WK Eddie Ip, Gloria Hoi Wan Tso, Man Wai Ng, Wilfred Hing Sang Wong, Helen Ka Wai Law, Raymond WH Yung, Eudora Y Chow, KL Au, Eric YT Chan, Wilina Lim, JS Malik Peiris, Yu Lung Lau

Published in: BMC Infectious Diseases | Issue 1/2006

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Abstract

Background

Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).

Methods

A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-γ,TNF-α and IL-10 for their associations with SARS.

Results

IFN-γ +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-γ +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-α were not associated with SARS susceptibility.

Conclusion

IFN-γ +874A allele was shown to be a risk factor in SARS susceptibility.
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Metadata
Title
The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome
Authors
Wai Po Chong
WK Eddie Ip
Gloria Hoi Wan Tso
Man Wai Ng
Wilfred Hing Sang Wong
Helen Ka Wai Law
Raymond WH Yung
Eudora Y Chow
KL Au
Eric YT Chan
Wilina Lim
JS Malik Peiris
Yu Lung Lau
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2006
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/1471-2334-6-82

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