Skip to main content
Top
Published in: BMC Geriatrics 1/2020

Open Access 01-12-2020 | Research article

The importance of different frailty domains in a population based sample in England

Authors: Solveig A. Arnadottir, Julie Bruce, Ranjit Lall, Emma J. Withers, Martin Underwood, Fiona Shaw, Ray Sheridan, Anower Hossain, Sarah E. Lamb, on behalf of the Pre-FIT Study Group

Published in: BMC Geriatrics | Issue 1/2020

Login to get access

Abstract

Background

The aim was to estimate the prevalence of frailty and relative contribution of physical/balance, nutritive, cognitive and sensory frailty to important adverse health states (falls, physical activity levels, outdoor mobility, problems in self-care or usual activities, and lack of energy or accomplishment) in an English cohort by age and sex.

Methods

Analysis of baseline data from a cohort of 9803 community-dwelling participants in a clinical trial. The sample was drawn from a random selection of all people aged 70 or more registered with 63 general practices across England. Data were collected by postal questionnaire. Frailty was measured with the Strawbridge questionnaire. We used cross sectional, multivariate logistic regression to estimate the association between frailty domains and known correlates and adjusted for age. Some models were stratified by sex.

Results

Mean age of participants was 78 years (sd 5.7), range 70 to 101 and 47.5% (4653/9803) were men. The prevalence of overall frailty was 20.7% (2005/9671) and there was no difference in prevalence by sex (Odds Ratio 0.98; 95% Confidence Interval 0.89 to 1.08). Sensory frailty was the most common and this was reported by more men (1823/4586) than women (1469/5056; Odds Ratio for sensory frailty 0.62, 95% Confidence Interval 0.57 to 0.68). Men were less likely than women to have physical or nutritive frailty. Physical frailty had the strongest independent associations with adverse health states. However, sensory frailty was independently associated with falls, less frequent walking, problems in self-care and usual activities, lack of energy and accomplishment.

Conclusions

Physical frailty was more strongly associated with adverse health states, but sensory frailty was much more common. The health gain from intervention for sensory frailty in England is likely to be substantial, particularly for older men. Sensory frailty should be explored further as an important target of intervention to improve health outcomes for older people both at clinical and population level.

Trial registration

Literature
1.
go back to reference Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRef Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRef
2.
go back to reference Cigolle CT, Ofstedal MB, Tian Z, Blaum CS. Comparing models of frailty: the health and retirement study. J Am Geriatr Soc. 2009;57(5):830–9.CrossRef Cigolle CT, Ofstedal MB, Tian Z, Blaum CS. Comparing models of frailty: the health and retirement study. J Am Geriatr Soc. 2009;57(5):830–9.CrossRef
3.
go back to reference Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, et al. Frailty: an emerging research and clinical paradigm—issues and controversies. J Gerontol A Biol Sci Med Sci. 2007;62(7):731–7.CrossRef Bergman H, Ferrucci L, Guralnik J, Hogan DB, Hummel S, Karunananthan S, et al. Frailty: an emerging research and clinical paradigm—issues and controversies. J Gerontol A Biol Sci Med Sci. 2007;62(7):731–7.CrossRef
4.
go back to reference Bouillon K, Kivimaki M, Hamer M, Sabia S, Fransson EI, Singh-Manoux A, et al. Measures of frailty in population-based studies: an overview. BMC Geriatr. 2013;13:64.CrossRef Bouillon K, Kivimaki M, Hamer M, Sabia S, Fransson EI, Singh-Manoux A, et al. Measures of frailty in population-based studies: an overview. BMC Geriatr. 2013;13:64.CrossRef
5.
go back to reference Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRef Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.CrossRef
6.
go back to reference Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489–95.CrossRef Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489–95.CrossRef
7.
go back to reference Bruce J, Lall R, Withers EJ, Finnegan S, Underwood M, Hulme C, et al. A cluster randomised controlled trial of advice, exercise or multifactorial assessment to prevent falls and fractures in community-dwelling older adults: protocol for the prevention of falls injury trial (PreFIT). BMJ Open. 2016;6(1):e009362.CrossRef Bruce J, Lall R, Withers EJ, Finnegan S, Underwood M, Hulme C, et al. A cluster randomised controlled trial of advice, exercise or multifactorial assessment to prevent falls and fractures in community-dwelling older adults: protocol for the prevention of falls injury trial (PreFIT). BMJ Open. 2016;6(1):e009362.CrossRef
8.
go back to reference Strawbridge WJ, Shema SJ, Balfour JL, Higby HR, Kaplan GA. Antecedents of frailty over three decades in an older cohort. J Gerontol B Psychol Sci Soc Sci. 1998;53(1):S9–16.CrossRef Strawbridge WJ, Shema SJ, Balfour JL, Higby HR, Kaplan GA. Antecedents of frailty over three decades in an older cohort. J Gerontol B Psychol Sci Soc Sci. 1998;53(1):S9–16.CrossRef
9.
go back to reference Buchner DM, Wagner EH. Preventing frail health. Clin Geriatr Med. 1992;8(1):1–17.CrossRef Buchner DM, Wagner EH. Preventing frail health. Clin Geriatr Med. 1992;8(1):1–17.CrossRef
10.
go back to reference Fried LP. Conference on the physiologic basis of frailty. April 28, 1992, Baltimore, Maryland, U.S.A. Introduction. Aging (Milano). 1992;4(3):251–2. Fried LP. Conference on the physiologic basis of frailty. April 28, 1992, Baltimore, Maryland, U.S.A. Introduction. Aging (Milano). 1992;4(3):251–2.
11.
go back to reference Guralnik JM, Simonsick EM. Physical disability in older Americans. J Gerontol. 1993;48 Spec No:3–10.CrossRef Guralnik JM, Simonsick EM. Physical disability in older Americans. J Gerontol. 1993;48 Spec No:3–10.CrossRef
12.
go back to reference Linard M, Herr M, Aegerter P, Czernichow S, Goldberg M, Zins M, et al. Should sensory impairment be considered in frailty assessment? A study in the GAZEL cohort. J Nutr Health Aging. 2016;20(7):714–21.CrossRef Linard M, Herr M, Aegerter P, Czernichow S, Goldberg M, Zins M, et al. Should sensory impairment be considered in frailty assessment? A study in the GAZEL cohort. J Nutr Health Aging. 2016;20(7):714–21.CrossRef
13.
go back to reference Martinot P, Landre B, Zins M, Goldberg M, Ankri J, Herr M. Association between potentially inappropriate medications and frailty in the early old age: a longitudinal ltudy in the GAZEL cohort. J Am Med Dir Assoc. 2018;19(11):967–973.e3.CrossRef Martinot P, Landre B, Zins M, Goldberg M, Ankri J, Herr M. Association between potentially inappropriate medications and frailty in the early old age: a longitudinal ltudy in the GAZEL cohort. J Am Med Dir Assoc. 2018;19(11):967–973.e3.CrossRef
14.
go back to reference Shua-Haim J, Koppuzha G, Gross J. A simple scoring system for clock drawing in patients with Alzheimer's disease. J Am Geriatr Soc. 1996;44(3):335.CrossRef Shua-Haim J, Koppuzha G, Gross J. A simple scoring system for clock drawing in patients with Alzheimer's disease. J Am Geriatr Soc. 1996;44(3):335.CrossRef
15.
go back to reference Ware J Jr, Kosinski M, Keller SD. A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220–33.CrossRef Ware J Jr, Kosinski M, Keller SD. A 12-item short-form health survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34(3):220–33.CrossRef
16.
go back to reference Lamb SE, Jorstad-Stein EC, Hauer K, Becker C. Prevention of falls network Europe and outcomes consensus group. Development of a common outcome data set for fall injury prevention trials: the prevention of falls network Europe consensus. J Am Geriatr Soc. 2005;53(9):1618–22.CrossRef Lamb SE, Jorstad-Stein EC, Hauer K, Becker C. Prevention of falls network Europe and outcomes consensus group. Development of a common outcome data set for fall injury prevention trials: the prevention of falls network Europe consensus. J Am Geriatr Soc. 2005;53(9):1618–22.CrossRef
17.
go back to reference Brooks R. EuroQol: the current state of play. Health Policy. 1996;37(1):53–72.CrossRef Brooks R. EuroQol: the current state of play. Health Policy. 1996;37(1):53–72.CrossRef
18.
go back to reference Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487–92.CrossRef Collard RM, Boter H, Schoevers RA, Oude Voshaar RC. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487–92.CrossRef
19.
go back to reference Crews JE, Campbell VA. Vision impairment and hearing loss among community-dwelling older Americans: implications for health and functioning. Am J Public Health. 2004;94(5):823–9.CrossRef Crews JE, Campbell VA. Vision impairment and hearing loss among community-dwelling older Americans: implications for health and functioning. Am J Public Health. 2004;94(5):823–9.CrossRef
20.
go back to reference Pang J, Beach EF, Gilliver M, Yeend I. Adults who report difficulty hearing speech in noise: an exploration of experiences, impacts and coping strategies. Int J Audiol. 2019;58(12):851–60.CrossRef Pang J, Beach EF, Gilliver M, Yeend I. Adults who report difficulty hearing speech in noise: an exploration of experiences, impacts and coping strategies. Int J Audiol. 2019;58(12):851–60.CrossRef
21.
go back to reference Matthews M, Lucas A, Boland R, Hirth V, Odenheimer G, Wieland D, et al. Use of a questionnaire to screen for frailty in the elderly: an exploratory study. Aging Clin Exp Res. 2004;16(1):34–40.CrossRef Matthews M, Lucas A, Boland R, Hirth V, Odenheimer G, Wieland D, et al. Use of a questionnaire to screen for frailty in the elderly: an exploratory study. Aging Clin Exp Res. 2004;16(1):34–40.CrossRef
22.
go back to reference Gale CR, Cooper C, Aihie SA. Prevalence of frailty and disability: findings from the English longitudinal study of ageing. Age Ageing. 2015;44(1):162–5.CrossRef Gale CR, Cooper C, Aihie SA. Prevalence of frailty and disability: findings from the English longitudinal study of ageing. Age Ageing. 2015;44(1):162–5.CrossRef
23.
go back to reference Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci. 2010;65(4):377–81.CrossRef Hubbard RE, Lang IA, Llewellyn DJ, Rockwood K. Frailty, body mass index, and abdominal obesity in older people. J Gerontol A Biol Sci Med Sci. 2010;65(4):377–81.CrossRef
24.
go back to reference Puts MT, Lips P, Deeg DJ. Sex differences in the risk of frailty for mortality independent of disability and chronic diseases. J Am Geriatr Soc. 2005;53(1):40–7.CrossRef Puts MT, Lips P, Deeg DJ. Sex differences in the risk of frailty for mortality independent of disability and chronic diseases. J Am Geriatr Soc. 2005;53(1):40–7.CrossRef
25.
go back to reference Syddall H, Roberts HC, Evandrou M, Cooper C, Bergman H, Aihie SA. Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire cohort study. Age Ageing. 2010;39(2):197–203.CrossRef Syddall H, Roberts HC, Evandrou M, Cooper C, Bergman H, Aihie SA. Prevalence and correlates of frailty among community-dwelling older men and women: findings from the Hertfordshire cohort study. Age Ageing. 2010;39(2):197–203.CrossRef
26.
go back to reference Gordon EH, Peel NM, Samanta M, Theou O, Howlett SE, Hubbard RE. Sex differences in frailty: a systematic review and meta-analysis. Exp Gerontol. 2017;89:30–40.CrossRef Gordon EH, Peel NM, Samanta M, Theou O, Howlett SE, Hubbard RE. Sex differences in frailty: a systematic review and meta-analysis. Exp Gerontol. 2017;89:30–40.CrossRef
27.
go back to reference Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, et al. Development and validation of an electronic frailty index using routine primary care electronic health record data. Age Ageing. 2016;45(3):353–60.CrossRef Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, et al. Development and validation of an electronic frailty index using routine primary care electronic health record data. Age Ageing. 2016;45(3):353–60.CrossRef
28.
go back to reference He W, Larsen L, US Census Bureau. American Community Survey Reports, ACS-29, Older Americans with a disability: 2008-2012. Washington, DC: US Government Printing Office; 2014. He W, Larsen L, US Census Bureau. American Community Survey Reports, ACS-29, Older Americans with a disability: 2008-2012. Washington, DC: US Government Printing Office; 2014.
29.
go back to reference Fried TR, Tinetti ME, Iannone L, O’Leary JR, Towle V, Van Ness PH. Health outcome prioritization as a tool for decision making among older persons with multiple chronic conditions. Arch Intern Med. 2011;171(20):1854–6.CrossRef Fried TR, Tinetti ME, Iannone L, O’Leary JR, Towle V, Van Ness PH. Health outcome prioritization as a tool for decision making among older persons with multiple chronic conditions. Arch Intern Med. 2011;171(20):1854–6.CrossRef
30.
go back to reference Grue EV, Ranhoff AH, Noro A, Finne-Soveri H, Jensdottir AB, Ljunggren G, et al. Vision and hearing impairments and their associations with falling and loss of instrumental activities in daily living in acute hospitalized older persons in five Nordic hospitals. Scand J Caring Sci. 2009;23(4):635–43.CrossRef Grue EV, Ranhoff AH, Noro A, Finne-Soveri H, Jensdottir AB, Ljunggren G, et al. Vision and hearing impairments and their associations with falling and loss of instrumental activities in daily living in acute hospitalized older persons in five Nordic hospitals. Scand J Caring Sci. 2009;23(4):635–43.CrossRef
31.
go back to reference Byrne C, Faure C, Keene DJ, Lamb SE. Ageing, muscle power and physical function: a systematic review and implications for pragmatic training interventions. Sports Med. 2016;46(9):1311–32.CrossRef Byrne C, Faure C, Keene DJ, Lamb SE. Ageing, muscle power and physical function: a systematic review and implications for pragmatic training interventions. Sports Med. 2016;46(9):1311–32.CrossRef
32.
go back to reference Lamoureux EL, Pallant JF, Pesudovs K, Rees G, Hassell JB, Keeffe JE. The effectiveness of low-vision rehabilitation on participation in daily living and quality of life. Invest Ophthalmol Vis Sci. 2007;48(4):1476–82.CrossRef Lamoureux EL, Pallant JF, Pesudovs K, Rees G, Hassell JB, Keeffe JE. The effectiveness of low-vision rehabilitation on participation in daily living and quality of life. Invest Ophthalmol Vis Sci. 2007;48(4):1476–82.CrossRef
33.
go back to reference Skelton DA, Howe TE, Ballinger C, Neil F, Palmer S, Gray L. Environmental and behavioural interventions for reducing physical activity limitation in community-dwelling visually impaired older people. Cochrane Database Syst Rev. 2013;6:Cd009233. Skelton DA, Howe TE, Ballinger C, Neil F, Palmer S, Gray L. Environmental and behavioural interventions for reducing physical activity limitation in community-dwelling visually impaired older people. Cochrane Database Syst Rev. 2013;6:Cd009233.
34.
go back to reference Ferguson MA, Kitterick PT, Chong LY, Edmondson-Jones M, Barker F, Hoare DJ. Hearing aids for mild to moderate hearing loss in adults. Cochrane Database Syst Rev. 2017;9:Cd012023.PubMed Ferguson MA, Kitterick PT, Chong LY, Edmondson-Jones M, Barker F, Hoare DJ. Hearing aids for mild to moderate hearing loss in adults. Cochrane Database Syst Rev. 2017;9:Cd012023.PubMed
36.
go back to reference Viksveen P, Relton C, Nicholl J. Benefits and challenges of using the cohort multiple randomised controlled trial design for testing an intervention for depression. Trials. 2017;18(1):308.CrossRef Viksveen P, Relton C, Nicholl J. Benefits and challenges of using the cohort multiple randomised controlled trial design for testing an intervention for depression. Trials. 2017;18(1):308.CrossRef
37.
go back to reference Lamb SE, McCabe C, Becker C, Fried LP, Guralnik JM. The optimal sequence and selection of screening test items to predict fall risk in older disabled women: the Women's health and aging study. J Gerontol A Biol Sci Med Sci. 2008;63(10):1082–8.CrossRef Lamb SE, McCabe C, Becker C, Fried LP, Guralnik JM. The optimal sequence and selection of screening test items to predict fall risk in older disabled women: the Women's health and aging study. J Gerontol A Biol Sci Med Sci. 2008;63(10):1082–8.CrossRef
38.
go back to reference Checa-López M, Oviedo-Briones M, Pardo-Gómez A, Gonzales-Turín J, Guevara-Guevara T, Carnicero JA, et al. FRAILTOOLS study protocol: a comprehensive validation of frailty assessment tools to screen and diagnose frailty in different clinical and social settings and to provide instruments for integrated care in older adults. BMC Geriatr. 2019;19(1):86.CrossRef Checa-López M, Oviedo-Briones M, Pardo-Gómez A, Gonzales-Turín J, Guevara-Guevara T, Carnicero JA, et al. FRAILTOOLS study protocol: a comprehensive validation of frailty assessment tools to screen and diagnose frailty in different clinical and social settings and to provide instruments for integrated care in older adults. BMC Geriatr. 2019;19(1):86.CrossRef
Metadata
Title
The importance of different frailty domains in a population based sample in England
Authors
Solveig A. Arnadottir
Julie Bruce
Ranjit Lall
Emma J. Withers
Martin Underwood
Fiona Shaw
Ray Sheridan
Anower Hossain
Sarah E. Lamb
on behalf of the Pre-FIT Study Group
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2020
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-019-1411-9

Other articles of this Issue 1/2020

BMC Geriatrics 1/2020 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.