Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
International Urology and Nephrology
Published in: International Urology and Nephrology 5/2018

01-05-2018 | Nephrology - Review

The impact of exercise on physical function, cardiovascular outcomes and quality of life in chronic kidney disease patients: a systematic review

Authors: Baris Afsar, Dimitrie Siriopol, Gamze Aslan, Ozgur C. Eren, Tuncay Dagel, Ugur Kilic, Asiye Kanbay, Alexandru Burlacu, Adrian Covic, Mehmet Kanbay

Published in: International Urology and Nephrology | Issue 5/2018

Login to get access

Abstract

The prevalence of chronic kidney disease (CKD) and end-stage renal disease (ESRD) is increasing steadily. CKD does not only relate to morbidity and mortality but also has impact on quality of life, depression and malnutrition. Such patients often have significantly decreased physical activity. Recent evidence suggests that low physical activity is associated with morbidity, mortality, muscle atrophy, quality of life impairment, cardiovascular outcomes and depression. Based on this, it is now recommended to regularly improve the physical activity of these patients. Furthermore, studies have shown the beneficial effects of various exercise programs with respect to outcomes such as low physical activity muscle atrophy, quality of life, cardiovascular outcomes and depression. Despite these encouraging findings, the subject is still under debate, with various aspects still unknown. In this review, we tried to critically summarize the existing studies, to explore mechanisms and describe future perspectives regarding physical activity in CKD/ESRD patients.
Literature
1.
Levin A, Tonelli M, Bonventre J, Coresh J, Donner JA, Fogo AB, Fox CS, Gansevoort RT, Heerspink HJL, Jardine M, Kasiske B, Kottgen A, Kretzler M, Levey AS, Luyckx VA, Mehta R, Moe O, Obrador G, Pannu N, Parikh CR, Perkovic V, Pollock C, Stenvinkel P, Tuttle KR, Wheeler DC, Eckardt KU, participants ISNGKHS (2017) Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy. Lancet 390:1888–1917CrossRefPubMed
2.
Ortiz A, Covic A, Fliser D, Fouque D, Goldsmith D, Kanbay M, Mallamaci F, Massy ZA, Rossignol P, Vanholder R, Wiecek A, Zoccali C, London GM (2014) Board of the E-mWGoERAE. Epidemiology, contributors to, and clinical trials of mortality risk in chronic kidney failure. Lancet 383:1831–1843CrossRefPubMed
3.
Zoccali C, Vanholder R, Massy ZA, Ortiz A, Sarafidis P, Dekker FW, Fliser D, Fouque D, Heine GH, Jager KJ, Kanbay M, Mallamaci F, Parati G, Rossignol P, Wiecek A, London G, European R (2017) Cardiovascular medicine working group of the European Renal Association—European dialysis transplantation A. The systemic nature of CKD. Nat Rev Nephrol 13:344–358CrossRefPubMed
4.
Afsar B, Kirkpantur A (2013) Are there any seasonal changes of cognitive impairment, depression, sleep disorders and quality of life in hemodialysis patients? Gen Hosp Psychiatry 35:28–32CrossRefPubMed
5.
Afsar B, Elsurer R, Kanbay M (2012) The relationship between breakfast, lunch and dinner eating pattern and hemodialysis sessions, quality of life, depression and appetite in hemodialysis patients. Int Urol Nephrol 44:1507–1514CrossRefPubMed
6.
Bae YH, Lee SM, Jo JI (2015) Aerobic training during hemodialysis improves body composition, muscle function, physical performance, and quality of life in chronic kidney disease patients. J Phys Therapy Sci 27:1445–1449CrossRef
7.
Fassbinder TR, Winkelmann ER, Schneider J, Wendland J, Oliveira OB (2015) Functional capacity and quality of life in patients with chronic kidney disease in pre-dialytic treatment and on hemodialysis—a cross sectional study. J Bras Nefrol 37:47–54CrossRefPubMed
8.
9.
Kopple JD, Kim JC, Shapiro BB, Zhang M, Li Y, Porszasz J, Bross R, Feroze U, Upreti R, Kalantar-Zadeh K (2015) Factors affecting daily physical activity and physical performance in maintenance dialysis patients. J Ren Nutr 25:217–222CrossRefPubMedPubMedCentral
10.
Cukor D, Ver Halen N, Asher DR, Coplan JD, Weedon J, Wyka KE, Saggi SJ, Kimmel PL (2014) Psychosocial intervention improves depression, quality of life, and fluid adherence in hemodialysis. J Am Soc Nephrol JASN 25:196–206CrossRefPubMed
11.
Huang CX, Tighiouart H, Beddhu S, Cheung AK, Dwyer JT, Eknoyan G, Beck GJ, Levey AS, Sarnak MJ (2010) Both low muscle mass and low fat are associated with higher all-cause mortality in hemodialysis patients. Kidney Int 77:624–629CrossRefPubMedPubMedCentral
12.
Rhee CM, Kalantar-Zadeh K (2014) Resistance exercise: an effective strategy to reverse muscle wasting in hemodialysis patients? J Cachexia Sarcopenia Muscle 5:177–180CrossRefPubMedPubMedCentral
13.
Workgroup KD (2005) K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients. Am J Kidney Dis 45:S1–S153
14.
Sietsema KE, Amato A, Adler SG, Brass EP (2004) Exercise capacity as a predictor of survival among ambulatory patients with end-stage renal disease. Kidney Int 65:719–724CrossRefPubMed
15.
Svarstad E, Myking O, Ofstad J, Iversen BM (2002) Effect of light exercise on renal hemodynamics in patients with hypertension and chronic renal disease. Scand J Urol Nephrol 36:464–472CrossRefPubMed
16.
Aoike DT, Baria F, Kamimura MA, Ammirati A, de Mello MT, Cuppari L (2015) Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease. Int Urol Nephrol 47:359–367CrossRefPubMed
17.
Samara AP, Kouidi E, Ouzouni S, Vasileiou S, Sioulis A, Deligiannis A (2013) Relationship between exercise test recovery indices and psychological and quality-of-life status in hemodialysis patients: a pilot study. J Nephrol 26:495–501CrossRefPubMed
18.
Heiwe S, Jacobson SH (2014) Exercise training in adults with CKD: a systematic review and meta-analysis. Am J Kidney Dis 64:383–393CrossRefPubMed
19.
Howden EJ, Leano R, Petchey W, Coombes JS, Isbel NM, Marwick TH (2013) Effects of exercise and lifestyle intervention on cardiovascular function in CKD. Clin J Am Soc Nephrol CJASN 8:1494–1501CrossRefPubMed
20.
Mustata S, Groeneveld S, Davidson W, Ford G, Kiland K, Manns B (2011) Effects of exercise training on physical impairment, arterial stiffness and health-related quality of life in patients with chronic kidney disease: a pilot study. Int Urol Nephrol 43:1133–1141CrossRefPubMed
21.
Stang A (2010) Critical evaluation of the Newcastle–Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25:603–605CrossRefPubMed
22.
Storer TW, Casaburi R, Sawelson S, Kopple JD (2005) Endurance exercise training during haemodialysis improves strength, power, fatigability and physical performance in maintenance haemodialysis patients. Nephrol Dial Transplant 20:1429–1437CrossRefPubMed
23.
Henrique DM, Reboredo Mde M, Chaoubah A (2010) Paula RB [Aerobic exercise improves physical capacity in patients under chronic hemodialysis]. Arq Bras Cardiol 94:823–828CrossRefPubMed
24.
Chan D, Green S, Fiatarone Singh M, Barnard R, Cheema BS (2016) Development, feasibility, and efficacy of a customized exercise device to deliver intradialytic resistance training in patients with end stage renal disease: non-randomized controlled crossover trial. Hemodial Int International Symp Home Hemodial 20:650–660CrossRef
25.
Musavian AS, Soleimani A, Masoudi Alavi N, Baseri A, Savari F (2015) Comparing the effects of active and passive intradialytic pedaling exercises on dialysis efficacy, electrolytes, hemoglobin, hematocrit, blood pressure and health-related quality of life. Nurs Midwifery Stud 4:e25922CrossRefPubMedPubMedCentral
26.
Parsons TL, Toffelmire EB, King-VanVlack CE (2006) Exercise training during hemodialysis improves dialysis efficacy and physical performance. Arch Phys Med Rehabil 87:680–687CrossRefPubMed
27.
Esteve Simo V, Junque Jimenez A, Moreno Guzman F, Carneiro Oliveira J, Fulquet Nicolas M, Pou Potau M, Saurina Sole A, Duarte Gallego V, Tapia Gonzalez I, Ramirez de Arellano M (2015) Benefits of a low intensity exercise programme during haemodialysis sessions in elderly patients. Nefrol Publ Of Soc Esp Nefrol 35:385–394
28.
Anding K, Bar T, Trojniak-Hennig J, Kuchinke S, Krause R, Rost JM, Halle M (2015) A structured exercise programme during haemodialysis for patients with chronic kidney disease: clinical benefit and long-term adherence. BMJ Open 5:e008709CrossRefPubMedPubMedCentral
29.
Painter P, Carlson L, Carey S, Paul SM, Myll J (2000) Physical functioning and health-related quality-of-life changes with exercise training in hemodialysis patients. Am J Kidney Dis 35:482–492CrossRefPubMed
30.
Painter P, Carlson L, Carey S, Paul SM, Myll J (2000) Low-functioning hemodialysis patients improve with exercise training. Am J Kidney Dis 36:600–608CrossRefPubMed
31.
Chang Y, Cheng SY, Lin M, Gau FY, Chao YF (2010) The effectiveness of intradialytic leg ergometry exercise for improving sedentary life style and fatigue among patients with chronic kidney disease: a randomized clinical trial. Int J Nurs Stud 47:1383–1388CrossRefPubMed
32.
Molsted S, Eidemak I, Sorensen HT, Kristensen JH (2004) Five months of physical exercise in hemodialysis patients: effects on aerobic capacity, physical function and self-rated health. Nephron Clin Pract 96:c76–c81CrossRefPubMed
33.
Cho H, Sohng KY (2014) The effect of a virtual reality exercise program on physical fitness, body composition, and fatigue in hemodialysis patients. J Phys Therapy sci 26:1661–1665CrossRef
34.
Heiwe S, Tollback A, Clyne N (2001) Twelve weeks of exercise training increases muscle function and walking capacity in elderly predialysis patients and healthy subjects. Nephron 88:48–56CrossRefPubMed
35.
Heiwe S, Clyne N, Tollback A, Borg K (2005) Effects of regular resistance training on muscle histopathology and morphometry in elderly patients with chronic kidney disease. Am J Phys Med Rehabil 84:865–874CrossRefPubMed
36.
Esteve Simo V, Junque A, Fulquet M, Duarte V, Saurina A, Pou M, Moreno F, Carneiro J, Ramirez de Arellano M (2014) Complete low-intensity endurance training programme in haemodialysis patients: improving the care of renal patients. Nephron Clin Pract 128:387–393CrossRefPubMed
37.
Moore GE, Painter PL, Brinker KR, Stray-Gundersen J, Mitchell JH (1998) Cardiovascular response to submaximal stationary cycling during hemodialysis. Am J Kidney Dis 31:631–637CrossRefPubMed
38.
Ting SM, Hamborg T, McGregor G, Oxborough D, Lim K, Koganti S, Aldridge N, Imray C, Bland R, Fletcher S, Krishnan NS, Higgins RM, Townend J, Banerjee P, Zehnder D (2015) Reduced cardiovascular reserve in chronic kidney failure: a matched cohort study. Am J Kidney Dis 66:274–284CrossRefPubMed
39.
Habedank D, Schefold JC, Bernhardt C, Karhausen T, Doehner W, Anker SD, Reinke P (2016) Vasodilation and exercise capacity in patients with end-stage renal disease: a prospective proof-of-concept study. Cardiorenal Med 7:50–59CrossRefPubMedPubMedCentral
40.
Ulubay G, Akman B, Sezer S, Calik K, Eyuboglu Oner F, Ozdemir N, Haberal M (2006) Factors affecting exercise capacity in renal transplantation candidates on continuous ambulatory peritoneal dialysis therapy. Transpl Proc 38:401–405CrossRef
41.
Ulubay G, Sezer S, Ulasli S, Ozdemir N, Eyuboglu OF, Haberal M (2006) Respiratory evaluation of patients on continuous ambulatory peritoneal dialysis prior to renal transplantation. Clin Nephrol 66:269–274CrossRefPubMed
42.
Sezer S, Elsurer R, Ulubay G, Ozdemir FN, Haberal M (2007) Factors associated with peak oxygen uptake in hemodialysis patients awaiting renal transplantation. Transpl Proc 39:879–882CrossRef
43.
Peres A, Perotto DL, Dorneles GP, Fuhro MI, Monteiro MB (2015) Effects of intradialytic exercise on systemic cytokine in patients with chronic kidney disease. Ren Fail 37:1430–1434CrossRefPubMed
44.
Reboredo MM, Neder JA, Pinheiro BV, Henrique DM, Faria RS, Paula RB (2011) Constant work-rate test to assess the effects of intradialytic aerobic training in mildly impaired patients with end-stage renal disease: a randomized controlled trial. Arch Phys Med Rehabil 92:2018–2024CrossRefPubMed
45.
Manfredini F, Mallamaci F, D’Arrigo G, Baggetta R, Bolignano D, Torino C, Lamberti N, Bertoli S, Ciurlino D, Rocca-Rey L, Barilla A, Battaglia Y, Rapana RM, Zuccala A, Bonanno G, Fatuzzo P, Rapisarda F, Rastelli S, Fabrizi F, Messa P, De Paola L, Lombardi L, Cupisti A, Fuiano G, Lucisano G, Summaria C, Felisatti M, Pozzato E, Malagoni AM, Castellino P, Aucella F, Abd ElHafeez S, Provenzano PF, Tripepi G, Catizone L, Zoccali C (2017) Exercise in patients on dialysis: a multicenter, randomized clinical trial. J Am Soc Nephrol JASN 28:1259–1268CrossRefPubMed
46.
Pomidori L, Lamberti N, Malagoni AM, Manfredini F, Pozzato E, Felisatti M, Catizone L, Barilla A, Zuccala A, Tripepi G, Mallamaci F, Zoccali C, Cogo A (2016) Respiratory muscle impairment in dialysis patients: can minimal dose of exercise limit the damage? A Preliminary study in a sample of patients enrolled in the EXCITE trial. J Nephrol 29:863–869CrossRefPubMed
47.
Thompson S, Klarenbach S, Molzahn A, Lloyd A, Gabrys I, Haykowsky M, Tonelli M (2016) Randomised factorial mixed method pilot study of aerobic and resistance exercise in haemodialysis patients: DIALY-SIZE! BMJ Open 6:e012085CrossRefPubMedPubMedCentral
48.
van Vilsteren MC, de Greef MH, Huisman RM (2005) The effects of a low-to-moderate intensity pre-conditioning exercise programme linked with exercise counselling for sedentary haemodialysis patients in The Netherlands: results of a randomized clinical trial. Nephrol Dial Transplant 20:141–146CrossRefPubMed
49.
Greenwood SA, Koufaki P, Mercer TH, Rush R, O’Connor E, Tuffnell R, Lindup H, Haggis L, Dew T, Abdulnassir L, Nugent E, Goldsmith D, Macdougall IC (2015) Aerobic or resistance training and pulse wave velocity in kidney transplant recipients: a 12-week pilot randomized controlled trial (the Exercise in Renal Transplant [ExeRT] Trial). Am J Kidney Dis 66:689–698CrossRefPubMed
50.
Greenwood SA, Koufaki P, Mercer TH, MacLaughlin HL, Rush R, Lindup H, O’Connor E, Jones C, Hendry BM, Macdougall IC, Cairns HS (2015) Effect of exercise training on estimated GFR, vascular health, and cardiorespiratory fitness in patients with CKD: a pilot randomized controlled trial. Am J Kidney Dis 65:425–434CrossRefPubMed
51.
Tang Q, Yang B, Fan F, Li P, Yang L, Guo Y (2017) Effects of individualized exercise program on physical function, psychological dimensions, and health-related quality of life in patients with chronic kidney disease: a randomized controlled trial in China. Int J Nurs Pract 23(2). https://​doi.​org/​10.​1111/​ijn.​12519
52.
de Lima MC, Cicotoste Cde L, Cardoso Kda S, Forgiarini LA Jr, Monteiro MB, Dias AS (2013) Effect of exercise performed during hemodialysis: strength versus aerobic. Ren Fail 35:697–704CrossRefPubMed
53.
Song WJ, Sohng KY (2012) Effects of progressive resistance training on body composition, physical fitness and quality of life of patients on hemodialysis. J Kor Acad Nurs 42:947–956CrossRef
54.
Dungey M, Bishop NC, Young HM, Burton JO, Smith AC (2015) The impact of exercising during haemodialysis on blood pressure, markers of cardiac injury and systemic inflammation-preliminary results of a pilot study. Kidney Blood Press Res 40:593–604CrossRefPubMed
55.
O’Hare AM, Tawney K, Bacchetti P, Johansen KL (2003) Decreased survival among sedentary patients undergoing dialysis: results from the dialysis morbidity and mortality study wave 2. Am J Kidney Dis 41:447–454CrossRefPubMed
56.
Stack AG, Molony DA, Rives T, Tyson J, Murthy BV (2005) Association of physical activity with mortality in the US dialysis population. Am J Kidney Dis 45:690–701CrossRefPubMed
57.
Barcellos FC, Santos IS, Umpierre D, Bohlke M, Hallal PC (2015) Effects of exercise in the whole spectrum of chronic kidney disease: a systematic review. Clin Kidney J 8:753–765CrossRefPubMedPubMedCentral
58.
Mercer TH, Crawford C, Gleeson NP, Naish PF (2002) Low-volume exercise rehabilitation improves functional capacity and self-reported functional status of dialysis patients. Am J Phys Med Rehabil 81:162–167CrossRefPubMed
59.
Johansen KL, Chertow GM, Kutner NG, Dalrymple LS, Grimes BA, Kaysen GA (2010) Low level of self-reported physical activity in ambulatory patients new to dialysis. Kidney Int 78:1164–1170CrossRefPubMedPubMedCentral
60.
Headley S, Germain M, Mailloux P, Mulhern J, Ashworth B, Burris J, Brewer B, Nindl BC, Coughlin M, Welles R, Jones M (2002) Resistance training improves strength and functional measures in patients with end-stage renal disease. Am J Kidney Dis 40:355–364CrossRefPubMed
61.
Nindl BC, Headley SA, Tuckow AP, Pandorf CE, Diamandi A, Khosravi MJ, Welles R, Jones M, Germain M (2004) IGF-I system responses during 12 weeks of resistance training in end-stage renal disease patients. Growth Horm IGF Res 14:245–250CrossRefPubMed
62.
Ridley J, Hoey K, Ballagh-Howes N (1999) The exercise-during-hemodialysis program: report on a pilot study. CANNT J J ACITN 9:20–26
63.
Oh-Park M, Fast A, Gopal S, Lynn R, Frei G, Drenth R, Zohman L (2002) Exercise for the dialyzed: aerobic and strength training during hemodialysis. Am J Phys Med Rehabil 81:814–821CrossRefPubMed
64.
Castaneda C, Gordon PL, Uhlin KL, Levey AS, Kehayias JJ, Dwyer JT, Fielding RA, Roubenoff R, Singh MF (2001) Resistance training to counteract the catabolism of a low-protein diet in patients with chronic renal insufficiency. A randomized, controlled trial. Ann Intern Med 135:965–976CrossRefPubMed
65.
Hickson RC (1980) Interference of strength development by simultaneously training for strength and endurance. Eur J Appl Physiol 45:255–263CrossRef
66.
Faria Rde S, Fernandes N, Lovisi JC, Reboredo Mde M, Marta MS, Pinheiro Bdo V, Bastos MG (2013) Pulmonary function and exercise tolerance are related to disease severity in pre-dialytic patients with chronic kidney disease: a cross-sectional study. BMC Nephrol 14:184CrossRefPubMed
67.
Casaburi R (2004) Rehabilitative exercise training in patients undergoing dialysis. In: Kopple JD (ed) SGM, editors. Nutritional management of renal disease. Lippincott, Williams and Wilkins, Baltimore, pp 605–620
68.
Koufaki P, Nash PF, Mercer TH (2002) Assessing the efficacy of exercise training in patients with chronic disease. Med Sci Sports Exerc 34:1234–1241CrossRefPubMed
69.
Goldberg AP, Geltman EM, Hagberg JM, Gavin JR 3rd, Delmez JA, Carney RM, Naumowicz A, Oldfield MH, Harter HR (1983) Therapeutic benefits of exercise training for hemodialysis patients. Kidney Int Suppl 16:S303–S309PubMed
70.
Akiba T, Matsui N, Shinohara S, Fujiwara H, Nomura T, Marumo F (1995) Effects of recombinant human erythropoietin and exercise training on exercise capacity in hemodialysis patients. Artif Organs 19:1262–1268CrossRefPubMed
71.
Downey RM, Liao P, Millson EC, Quyyumi AA, Sher S, Park J (2017) Endothelial dysfunction correlates with exaggerated exercise pressor response during whole body maximal exercise in chronic kidney disease. Am J Physiol Ren Physiol ajprenal 00603 02016
72.
Blacher J, Safar ME, Guerin AP, Pannier B, Marchais SJ, London GM (2003) Aortic pulse wave velocity index and mortality in end-stage renal disease. Kidney Int 63:1852–1860CrossRefPubMed
73.
Dahle DO, Eide IA, Asberg A, Leivestad T, Holdaas H, Jenssen TG, Fagerland MW, Pihlstrom H, Mjoen G, Hartmann A (2015) Aortic stiffness in a mortality risk calculator for kidney transplant recipients. Transplantation 99:1730–1737CrossRefPubMed
74.
Toussaint ND, Polkinghorne KR, Kerr PG (2008) Impact of intradialytic exercise on arterial compliance and B-type natriuretic peptide levels in hemodialysis patients. Hemodial Int International Symp Home Hemodial 12:254–263CrossRef
75.
Mihaescu A, Avram C, Bob F, Gaita D, Schiller O, Schiller A (2013) Benefits of exercise training during hemodialysis sessions: a prospective cohort study. Nephron Clin Pract 124:72–78CrossRefPubMed
76.
Mustata S, Chan C, Lai V, Miller JA (2004) Impact of an exercise program on arterial stiffness and insulin resistance in hemodialysis patients. J Am Soc Nephrol JASN 15:2713–2718CrossRefPubMed
77.
Miller BW, Cress CL, Johnson ME, Nichols DH, Schnitzler MA (2002) Exercise during hemodialysis decreases the use of antihypertensive medications. Am J Kidney Dis 39:828–833CrossRefPubMed
78.
Hagberg JM, Goldberg AP, Ehsani AA, Heath GW, Delmez JA, Harter HR (1983) Exercise training improves hypertension in hemodialysis patients. Am J Nephrol 3:209–212CrossRefPubMed
79.
Deligiannis A, Kouidi E, Tassoulas E, Gigis P, Tourkantonis A, Coats A (1999) Cardiac effects of exercise rehabilitation in hemodialysis patients. Int J Cardiol 70:253–266CrossRefPubMed
80.
Smart N, Steele M (2011) Exercise training in haemodialysis patients: a systematic review and meta-analysis. Nephrology 16:626–632PubMed
81.
Scrutinio D, Agostoni P, Gesualdo L, Corra U, Mezzani A, Piepoli M, Di Lenarda A, Iorio A, Passino C, Magri D, Masarone D, Battaia E, Girola D, Re F, Cattadori G, Parati G, Sinagra G, Villani GQ, Limongelli G, Pacileo G, Guazzi M, Metra M, Frigerio M, Cicoira M, Mina C, Malfatto G, Caravita S, Bussotti M, Salvioni E, Veglia F, Correale M, Scardovi AB, Emdin M, Giannuzzi P, Gargiulo P, Giovannardi M, Perrone-Filardi P, Raimondo R, Ricci R, Paolillo S, Farina S, Belardinelli R, Passantino A, La Gioia R, Metabolic Exercise test data combined with C, Kidney Indexes Score Research G (2015) Renal function and peak exercise oxygen consumption in chronic heart failure with reduced left ventricular ejection fraction. Circ J 79:583–591CrossRefPubMed
82.
Suh MR, Jung HH, Kim SB, Park JS, Yang WS (2002) Effects of regular exercise on anxiety, depression, and quality of life in maintenance hemodialysis patients. Ren Fail 24:337–345CrossRefPubMed
83.
Qing DTZ, Ding H et al (1999) Effect of exercise training of gene expression for igf-1, igf-r and igfbps in skeletal muscle of maintenance hemodialysis patients. J Am Soc Nephrol 10:266A
84.
Afsar B, Rossignol P, van Heerebeek L, Paulus WJ, Damman K, Heymans S, van Empel V, Sag A, Maisel A, Kanbay M (2017) Heart failure with preserved ejection fraction: a nephrologist-directed primer. Heart Fail Rev 22:765–773CrossRefPubMed
85.
Schlaich MP, Socratous F, Hennebry S, Eikelis N, Lambert EA, Straznicky N, Esler MD, Lambert GW (2009) Sympathetic activation in chronic renal failure. J Am Soc Nephrol JASN 20:933–939CrossRefPubMed
86.
Grassi G, Quarti-Trevano F, Seravalle G, Arenare F, Volpe M, Furiani S, Dell’Oro R, Mancia G (2011) Early sympathetic activation in the initial clinical stages of chronic renal failure. Hypertension 57:846–851CrossRefPubMed
87.
Petersson M, Friberg P, Eisenhofer G, Lambert G, Rundqvist B (2005) Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure. Eur Heart J 26:906–913CrossRefPubMed
88.
89.
Brum PC, Bacurau AVN, Medeiros A, Ferreira JCB, Vanzelli AS, Negrão CE (2011) Aerobic exercise training in heart failure: impact on sympathetic hyperactivity and cardiac and skeletal muscle function. Braz J Med Biol Res 44:827–835CrossRefPubMed
90.
Lin AM, Liao P, Millson EC, Quyyumi AA, Park J (2016) Tetrahydrobiopterin ameliorates the exaggerated exercise pressor response in patients with chronic kidney disease: a randomized controlled trial. Am J Physiol Ren Physiol 310:F1016–F1025CrossRef
91.
Park J, Quyyumi AA, Middlekauff HR (2013) Exercise pressor response and arterial baroreflex unloading during exercise in chronic kidney disease. J Appl Physiol 114:538–549CrossRefPubMed
92.
Bergamaschi CT, Campos RR, Lopes OU (1999) Rostral ventrolateral medulla. A source of sympathetic activation in rats subjected to long-term treatment with L-NAME. Hypertension 34:744–747CrossRefPubMed
93.
Sander M, Chavoshan B, Victor RG (1999) A large blood pressure-raising effect of nitric oxide synthase inhibition in humans. Hypertension 33:937–942CrossRefPubMed
94.
Luiz Rda S, Silva KA, Rampaso RR, Antonio EL, Montemor J, Bocalini DS, Dos Santos L, Moura L, Tucci PJ, de Abreu NP, Schor N (2013) Exercise attenuates renal dysfunction with preservation of myocardial function in chronic kidney disease. PLoS ONE 8:e55363CrossRefPubMed
95.
Adams GR, Vaziri ND (2006) Skeletal muscle dysfunction in chronic renal failure: effects of exercise. Am J Physiol Ren Physiol 290:F753–F761CrossRef
96.
Piepoli MF, Guazzi M, Boriani G, Cicoira M, Corra U, Dalla Libera L, Emdin M, Mele D, Passino C, Vescovo G, Vigorito C, Villani G, Agostoni P, Working Group ‘Exercise Physiology SC, Cardiac Rehabilitation ISoC (2010) Exercise intolerance in chronic heart failure: mechanisms and therapies. Part II. Eur J Cardiovasc Prev Rehab 17:643–648CrossRef
97.
Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, Nimmo MA (2011) The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 11:607–615CrossRefPubMed
98.
Viana JL, Kosmadakis GC, Watson EL, Bevington A, Feehally J, Bishop NC, Smith AC (2014) Evidence for anti-inflammatory effects of exercise in CKD. J Am Soc Nephrol 25:2121–2130CrossRefPubMedPubMedCentral
99.
Sato T, Yamauchi H, Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y (2013) Distinct prognostic factors in patients with chronic heart failure and chronic kidney disease. Int Heart J 54:311–317CrossRefPubMed
Metadata
Title
The impact of exercise on physical function, cardiovascular outcomes and quality of life in chronic kidney disease patients: a systematic review
Authors
Baris Afsar
Dimitrie Siriopol
Gamze Aslan
Ozgur C. Eren
Tuncay Dagel
Ugur Kilic
Asiye Kanbay
Alexandru Burlacu
Adrian Covic
Mehmet Kanbay
Publication date
01-05-2018
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 5/2018
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-018-1790-4

Other articles of this Issue 5/2018

International Urology and Nephrology 5/2018 Go to the issue

Urology - Original Paper

Comparison of Vela and holmium laser enucleation of the prostate: a retrospective clinical trial with a 12-month follow-up

Nephrology - Original Paper

Disparities in early mortality among chronic kidney disease patients who transition to peritoneal dialysis and hemodialysis with and without catheters

Nephrology - Original Paper

Vitamin D supplementation improves endothelial dysfunction in patients with non-dialysis chronic kidney disease

Nephrology - Original Paper

Prognostic value of cardiovascular calcifications in hemodialysis patients: a longitudinal study

Nephrology - Review

The role of zinc in urinary stone disease

Urology - Letter to the Editor

Re: Lebentrau S, Gilfrich C, Vetterlein MW, Schumacher H, Spachmann PJ, Brookman-May SD, Fritsche HM, Schostak M, Wagenlehner F, Burger M, May M, MR2 study group (2017) Impact of the medical specialty on knowledge regarding multidrug-resistant organisms and strategies toward antimicrobial stewardship. Int Urol Nephrol 49:1311–1318
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits