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Molecular Cancer
Published in: Molecular Cancer 1/2011

Open Access 01-12-2011 | Review

The functional role of long non-coding RNA in human carcinomas

Authors: Ewan A Gibb, Carolyn J Brown, Wan L Lam

Published in: Molecular Cancer | Issue 1/2011

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Abstract

Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm demonstrating potential roles in both oncogenic and tumor suppressive pathways. These novel genes are frequently aberrantly expressed in a variety of human cancers, however the biological functions of the vast majority remain unknown. Recently, evidence has begun to accumulate describing the molecular mechanisms by which these RNA species function, providing insight into the functional roles they may play in tumorigenesis. In this review, we highlight the emerging functional role of lncRNAs in human cancer.
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Metadata
Title
The functional role of long non-coding RNA in human carcinomas
Authors
Ewan A Gibb
Carolyn J Brown
Wan L Lam
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2011
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-10-38

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