Published in:
Open Access 01-12-2012 | Case report
The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?
Published in: Malaria Journal | Issue 1/2012
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Background
Plasmodium falciparum immature gametocytes accumulate in the bone marrow, but their exact location in this tissue remains unclear.
Methods
The stage and deposition pattern of gametocytes was analysed on histological sections of a bone marrow sample collected in a patient with subacute P. falciparum malaria.
Results
A majority (89%) of immature stages II to IV gametocytes and a minority (29%) of mature stage V gametocytes were observed in extravascular spaces.
Discussion and conclusion
These observations represent a valuable step towards understanding sequestration patterns of P. falciparum gametocytes and may ultimately lead to novel transmission-blocking interventions.