Top

Published in:

01-02-2006 | Poster presentation

The erythropoietin neuroprotective effect: assessment in coronary artery bypass graft surgery (TENPEAKS) – a randomized, double-blind, placebo-controlled, proof-of-concept clinical trial

Authors: G Haljan, A Maitland, A Buchan, M King, J Haigh, B Culleton, P Faris, D Zygun

Published in: Critical Care | Special Issue 1/2006

Excerpt

Human recombinant erythropoietin (rh-Epo) may be a potent neuroprotectant [1]. It is approved in Canada to reduce blood transfusions in coronary artery bypass graft (CABG) surgery, which is complicated by neurocognitive dysfunction (NCD) in 50–80% of patients at discharge, 10–36% at 6 weeks and 42% at 5 years [2]. We conducted a randomized, double-blind, placebo-controlled study in 32 first-time CABG patients to investigate the feasibility and safety of three doses of rh-Epo with the ultimate goal of reducing NCD in patients following CABG. …

Ehrenreich H, et al.: Mol Med. 2002, 8: 495-505.PubMedCentralPubMed

Newman, et al.: N Engl J Med. 2001, 344: 395-402. 10.1056/NEJM200102083440601CrossRefPubMed

Title: The erythropoietin neuroprotective effect: assessment in coronary artery bypass graft surgery (TENPEAKS) – a randomized, double-blind, placebo-controlled, proof-of-concept clinical trial
Authors: G Haljan
A Maitland
A Buchan
M King
J Haigh
B Culleton
P Faris
D Zygun
Publication date: 01-02-2006
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 1/2006
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc4574

At a glance: The STEP trials

Springer Medicine

The erythropoietin neuroprotective effect: assessment in coronary artery bypass graft surgery (TENPEAKS) – a randomized, double-blind, placebo-controlled, proof-of-concept clinical trial

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Special Issue 1/2006

The effect of polymixin B immobilized on fibers and continuous veno-venous hemodiafiltration on tetrahydrobiopterine and NO metabolites in septic patients

Does volume substitution with HES 130/0.4 affect renal safety in abdominal aortic surgery?

Assessment of the effectiveness of lung recruitment and PEEP setting by vibration response imaging

Preoperative nutrition support with or without glutamine can reduce ICU admissions

Patients with liver transplantation readmitted to the ICU: a 15-year retrospective study

Improved hepatic glucose production in mice lacking inducible nitric oxide synthase during hyperdynamic septic shock