Published in:
01-02-2006 | Poster presentation
The effect of polymixin B immobilized on fibers and continuous veno-venous hemodiafiltration on tetrahydrobiopterine and NO metabolites in septic patients
Authors:
Y Kakihana, K Hayashida, Y Takahashi, Y Setoguchi, T Sonoda, T Imabayashi, A Matsunaga, T Hashiguchi, Y Kanmura, H Nakazawa
Published in:
Critical Care
|
Special Issue 1/2006
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Excerpt
Hemoperfusion with a column of polymixin B immobilized on fibers (PMX) increases the blood pressure too rapidly for the effect to be attributable to endotoxin removal. On the other hand, continuous veno-venous hemodiafiltration (CVVHDF) also has effects of increasing blood pressure in septic patients. Since inducible NO synthase (iNOS) is known to be involved in the profound hypotension, we hypothesized that a decrease of tetra-hydrobiopterine (BH4), an essential cofactor of iNOS, might account for the rapid effect of PMX and CVVHDF on blood pressure, if PMX and CVVHDF can decrease BH4. In this study we therefore measured the plasma level of BH4 and NO metabolites (NOx) in septic patients, and evaluated whether PMX and CVVHDF can decrease them. …
