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Molecular Cancer
Published in: Molecular Cancer 1/2017

Open Access 01-12-2017 | Review

The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

Authors: Pingting Zhou, Bo Li, Furao Liu, Meichao Zhang, Qian Wang, Yuanhua Liu, Yuan Yao, Dong Li

Published in: Molecular Cancer | Issue 1/2017

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Abstract

The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer. These findings highlight the importance of confirming stem-cells markers and complex molecular signaling pathways controlling EMT and cancer stem cells in pancreatic cancer during tumor formation, progression, and response to therapy.
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Metadata
Title
The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
Authors
Pingting Zhou
Bo Li
Furao Liu
Meichao Zhang
Qian Wang
Yuanhua Liu
Yuan Yao
Dong Li
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2017
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-017-0624-9

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