Skip to main content
Top
Published in: AIDS and Behavior 5/2014

01-10-2014 | Original Paper

The Enabling Effect of Food Assistance in Improving Adherence and/or Treatment Completion for Antiretroviral Therapy and Tuberculosis Treatment: A Literature Review

Authors: Saskia de Pee, Nils Grede, Divya Mehra, Martin W. Bloem

Published in: AIDS and Behavior | Special Issue 5/2014

Login to get access

Abstract

Socioeconomic costs of HIV and TB and the difficulty of maintaining optimal treatment are well documented. Social protection measures such as food assistance may be required to offset some of the treatment related costs as well as to ensure food security and maintain good health of the affected individual and household. Programmes have started placing greater emphasis on treatment adherence and are looking for proven interventions that can optimize it. This paper looks at the effect of food assistance for enabling treatment adherence and reviews studies that used food assistance to promote adherence. Eight of ten studies found that provision of food can improve adherence and/or treatment completion for HIV care and treatment, ART and TB-DOTS. This indicates that food provision is not only a biological, but also a behavioural intervention, and underscores that unresolved food insecurity can be an impediment to treatment adherence and consequently to good treatment outcomes.
Footnotes
1
The term incentive is widely used in much of the literature but for the purposes of this paper the term “enabler” is adopted except when necessary to preserve the language used in referenced publications.
 
Literature
1.
go back to reference Au JT, Kayitenkore K, Shutes E, et al. Access to adequate nutrition is a major potential obstacle to antiretroviral adherence among HIV-infected individuals in Rwanda. AIDS. 2006;20(16):2116–8.PubMedCrossRef Au JT, Kayitenkore K, Shutes E, et al. Access to adequate nutrition is a major potential obstacle to antiretroviral adherence among HIV-infected individuals in Rwanda. AIDS. 2006;20(16):2116–8.PubMedCrossRef
2.
go back to reference Chileshe M, Bond VA. Barriers and outcomes: TB patients co-infected with HIV accessing antiretroviral therapy in rural Zambia. AIDS Care. 2010;22(1):51–9.PubMedCrossRef Chileshe M, Bond VA. Barriers and outcomes: TB patients co-infected with HIV accessing antiretroviral therapy in rural Zambia. AIDS Care. 2010;22(1):51–9.PubMedCrossRef
3.
go back to reference Escott S, Newell J. Don’t forget the bigger picture: the impact of societal issues on a community-based TB programme, Swaziland. J Health Organ Manag. 2007;21(6):506–18.PubMedCrossRef Escott S, Newell J. Don’t forget the bigger picture: the impact of societal issues on a community-based TB programme, Swaziland. J Health Organ Manag. 2007;21(6):506–18.PubMedCrossRef
4.
go back to reference Gebremariam MK, Bjune GA, Frich JC. Barriers and facilitators of adherence to TB treatment in patients on concomitant TB and HIV treatment: a qualitative study. BMC Public Health. 2010;10:651.PubMedPubMedCentral Gebremariam MK, Bjune GA, Frich JC. Barriers and facilitators of adherence to TB treatment in patients on concomitant TB and HIV treatment: a qualitative study. BMC Public Health. 2010;10:651.PubMedPubMedCentral
5.
go back to reference Harvey KM, Carrington D, Duncan J, Figueroa JP, Hirschorn L, Manning D, Jackson S. Evaluation of adherence to highly active antiretroviral therapy in adults in Jamaica. West Indian Med J. 2008;57(3):293–7.PubMed Harvey KM, Carrington D, Duncan J, Figueroa JP, Hirschorn L, Manning D, Jackson S. Evaluation of adherence to highly active antiretroviral therapy in adults in Jamaica. West Indian Med J. 2008;57(3):293–7.PubMed
6.
go back to reference Kalichman SC, Grebler T. Stress and poverty predictors of treatment adherence among people with low-literacy living with HIV/AIDS. Psychosom Med. 2010;72(8):810–6.PubMedCrossRefPubMedCentral Kalichman SC, Grebler T. Stress and poverty predictors of treatment adherence among people with low-literacy living with HIV/AIDS. Psychosom Med. 2010;72(8):810–6.PubMedCrossRefPubMedCentral
7.
go back to reference Kalichman SC, Cherry C, Amaral C, et al. Health and treatment implications of food insufficiency among people living with HIV/AIDS, Atlanta, Georgia. J Urban Health. 2012;87(4):631–41.CrossRef Kalichman SC, Cherry C, Amaral C, et al. Health and treatment implications of food insufficiency among people living with HIV/AIDS, Atlanta, Georgia. J Urban Health. 2012;87(4):631–41.CrossRef
8.
go back to reference Mshana GH, Wamoyi J, Busza J, et al. Barriers to accessing antiretroviral therapy in Kisesa, Tanzania: a qualitative study of early rural Referrals to the national program. AIDS Patient Care STDs. 2006;20(9):649–57.PubMedCrossRef Mshana GH, Wamoyi J, Busza J, et al. Barriers to accessing antiretroviral therapy in Kisesa, Tanzania: a qualitative study of early rural Referrals to the national program. AIDS Patient Care STDs. 2006;20(9):649–57.PubMedCrossRef
9.
go back to reference Nachega JB, Knowlton AR, Deluca A, et al. Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults: a qualitative study. J Acquir Immune Defic Syndr. 2006;43:S127–33.PubMedCrossRef Nachega JB, Knowlton AR, Deluca A, et al. Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults: a qualitative study. J Acquir Immune Defic Syndr. 2006;43:S127–33.PubMedCrossRef
10.
go back to reference Olupot-Olupot P, Katawera A, Cooper C, Small W, Anema A, Mills E. Adherence to antiretroviral therapy among a conflict-affected population in Northeastern Uganda: a qualitative study. AIDS. 2008;22(14):1882–4.PubMedCrossRef Olupot-Olupot P, Katawera A, Cooper C, Small W, Anema A, Mills E. Adherence to antiretroviral therapy among a conflict-affected population in Northeastern Uganda: a qualitative study. AIDS. 2008;22(14):1882–4.PubMedCrossRef
11.
go back to reference Sanjobo N, Frich JC, Fretheim A. Barriers and facilitators to patients’ adherence to antiretroviral treatment in Zambia: a qualitative study. SAHARA J. 2008;5(3):136–43.PubMedCrossRef Sanjobo N, Frich JC, Fretheim A. Barriers and facilitators to patients’ adherence to antiretroviral treatment in Zambia: a qualitative study. SAHARA J. 2008;5(3):136–43.PubMedCrossRef
12.
13.
go back to reference Unge C, Johansson A, Zachariah R, Some D, Van Engelgem I, Ekstrom AM. Reasons for unsatisfactory acceptance of antiretroviral treatment in the urban Kibera slum, Kenya. AIDS Care. 2008;20(2):146–9.PubMedCrossRef Unge C, Johansson A, Zachariah R, Some D, Van Engelgem I, Ekstrom AM. Reasons for unsatisfactory acceptance of antiretroviral treatment in the urban Kibera slum, Kenya. AIDS Care. 2008;20(2):146–9.PubMedCrossRef
14.
go back to reference Weiser S, Wolfe W, Bangsberg D, et al. Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J Acquir Immune Defic Syndr. 2003;34(3):281–8.PubMedCrossRef Weiser S, Wolfe W, Bangsberg D, et al. Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J Acquir Immune Defic Syndr. 2003;34(3):281–8.PubMedCrossRef
15.
go back to reference Weiser SD, Frongillo EA, Ragland K, Hogg RS, Riley ED, Bangsberg DR. Food insecurity is associated with incomplete HIV RNA suppression among homeless and marginally housed HIV-infected individuals in San Francisco. J Gen Intern Med. 2008;24(1):14–20.PubMedCrossRefPubMedCentral Weiser SD, Frongillo EA, Ragland K, Hogg RS, Riley ED, Bangsberg DR. Food insecurity is associated with incomplete HIV RNA suppression among homeless and marginally housed HIV-infected individuals in San Francisco. J Gen Intern Med. 2008;24(1):14–20.PubMedCrossRefPubMedCentral
16.
go back to reference Weiser SD, Fernandes KA, Brandson EK, et al. The association between food insecurity and mortality among HIV-infected individuals on HAART. J Acquir Immune Defic Syndr. 2009;52(3):342–9.PubMedCrossRefPubMedCentral Weiser SD, Fernandes KA, Brandson EK, et al. The association between food insecurity and mortality among HIV-infected individuals on HAART. J Acquir Immune Defic Syndr. 2009;52(3):342–9.PubMedCrossRefPubMedCentral
17.
go back to reference Weiser SD, Tuller DM, Frongillo EA, Senkungu J, Mukiibi N, Bangsberg DR. Food insecurity as a barrier to sustained antiretroviral therapy adherence in Uganda. PLoS One. 2010;5(4):10340.CrossRef Weiser SD, Tuller DM, Frongillo EA, Senkungu J, Mukiibi N, Bangsberg DR. Food insecurity as a barrier to sustained antiretroviral therapy adherence in Uganda. PLoS One. 2010;5(4):10340.CrossRef
18.
go back to reference Stone VE, Hogan JW, Schuman P, et al. Antiretroviral regimen complexity, self-reported adherence, and HIV patients’ understanding of their regimens: survey of women in the HER study. J AIDS. 2001;28:124–31. Stone VE, Hogan JW, Schuman P, et al. Antiretroviral regimen complexity, self-reported adherence, and HIV patients’ understanding of their regimens: survey of women in the HER study. J AIDS. 2001;28:124–31.
19.
go back to reference Ayé R, Wyss K, Abdualimova H, Saidaliev S. Illness costs to households are a key barrier to access diagnostic and treatment services for tuberculosis in Tajikistan. BMC Res Notes. 2010;3:340.PubMedCrossRefPubMedCentral Ayé R, Wyss K, Abdualimova H, Saidaliev S. Illness costs to households are a key barrier to access diagnostic and treatment services for tuberculosis in Tajikistan. BMC Res Notes. 2010;3:340.PubMedCrossRefPubMedCentral
20.
go back to reference Cramm JM, Finkenflügel HJM, Moller V, Nieboer AP. TB treatment initiation and adherence in a South African community influenced more by perceptions than by knowledge of tuberculosis. BMC Public Health. 2010;10:72.PubMedCrossRefPubMedCentral Cramm JM, Finkenflügel HJM, Moller V, Nieboer AP. TB treatment initiation and adherence in a South African community influenced more by perceptions than by knowledge of tuberculosis. BMC Public Health. 2010;10:72.PubMedCrossRefPubMedCentral
21.
go back to reference Hoa NP, Thorson AEK, Long NH, Diwan VK. Knowledge of tuberculosis and associated health-seeking behaviour among rural Vietnamese adults with a cough for at least three weeks. Scand J Public Health Suppl. 2003;31(Suppl. 62):59–65.CrossRef Hoa NP, Thorson AEK, Long NH, Diwan VK. Knowledge of tuberculosis and associated health-seeking behaviour among rural Vietnamese adults with a cough for at least three weeks. Scand J Public Health Suppl. 2003;31(Suppl. 62):59–65.CrossRef
22.
go back to reference Ostrop NJ, Hallett KA, Gill MJ. Long-term patient adherence to antiretroviral therapy. Ann Pharmacother. 2000;34(6):703–9.PubMedCrossRef Ostrop NJ, Hallett KA, Gill MJ. Long-term patient adherence to antiretroviral therapy. Ann Pharmacother. 2000;34(6):703–9.PubMedCrossRef
23.
go back to reference Heath KV, Singer J, O’Shaughnessy MV, Montaner JSG, Hogg RS. Intentional nonadherence due to adverse symptoms associated with antiretroviral therapy. J AIDS. 2002;31(2):211–7. Heath KV, Singer J, O’Shaughnessy MV, Montaner JSG, Hogg RS. Intentional nonadherence due to adverse symptoms associated with antiretroviral therapy. J AIDS. 2002;31(2):211–7.
25.
go back to reference Kranzer K, Govindasamy D, Ford N, Johnston V, Lawn SD. Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review. J Int Aids Soc. 2012;15:17383.PubMedCrossRefPubMedCentral Kranzer K, Govindasamy D, Ford N, Johnston V, Lawn SD. Quantifying and addressing losses along the continuum of care for people living with HIV infection in sub-Saharan Africa: a systematic review. J Int Aids Soc. 2012;15:17383.PubMedCrossRefPubMedCentral
26.
go back to reference De Pee S, Semba RD. Role of nutrition in HIV infection: review of evidence for more effective programming in resource-limited settings. Food Nutr Bull. 2010;4:S313–44. De Pee S, Semba RD. Role of nutrition in HIV infection: review of evidence for more effective programming in resource-limited settings. Food Nutr Bull. 2010;4:S313–44.
27.
go back to reference Gross R, Blumel C. Literature review of tuberculosis (TB) intervention studies. Washington: USAID, KSC Research Series; 2008. Gross R, Blumel C. Literature review of tuberculosis (TB) intervention studies. Washington: USAID, KSC Research Series; 2008.
28.
go back to reference Bock NN, Sales R-M, Rogers T, DeVoe B. A spoonful of sugar…: improving adherence to tuberculosis treatment using financial incentives. Int J Tuberc Lung Dis. 2001;5(1):96–8.PubMed Bock NN, Sales R-M, Rogers T, DeVoe B. A spoonful of sugar…: improving adherence to tuberculosis treatment using financial incentives. Int J Tuberc Lung Dis. 2001;5(1):96–8.PubMed
29.
go back to reference Filho JPC. Food baskets given to tuberculosis patients at a primary health care clinic in the city of Duque de Caxias, Brazil: effect on treatment outcomes. J Bras Pneumol. 2009;35(10):992–7.CrossRef Filho JPC. Food baskets given to tuberculosis patients at a primary health care clinic in the city of Duque de Caxias, Brazil: effect on treatment outcomes. J Bras Pneumol. 2009;35(10):992–7.CrossRef
30.
go back to reference Martins N, Morris P, Kelly PM. Food Incentives to improve completion of tuberculosis treatment: randomised controlled trial in Dili, Timor-Leste. BMJ. 2009;339:b4248.PubMedCrossRefPubMedCentral Martins N, Morris P, Kelly PM. Food Incentives to improve completion of tuberculosis treatment: randomised controlled trial in Dili, Timor-Leste. BMJ. 2009;339:b4248.PubMedCrossRefPubMedCentral
31.
go back to reference Jahnavi G, Sudha CH. Randomised controlled trial of food supplements in patients with newly diagnosed tuberculosis and wasting. Singap Med J. 2010;51(12):957–62. Jahnavi G, Sudha CH. Randomised controlled trial of food supplements in patients with newly diagnosed tuberculosis and wasting. Singap Med J. 2010;51(12):957–62.
32.
go back to reference Ivers LC, Chang Y, Jerome JG, Freedberg KA. Food assistance is associated with improved body mass index, food security and attendance at clinic in an HIV program in central Haiti: a prospective observational cohort study. AIDS Res Ther. 2010;7:33.PubMedCrossRefPubMedCentral Ivers LC, Chang Y, Jerome JG, Freedberg KA. Food assistance is associated with improved body mass index, food security and attendance at clinic in an HIV program in central Haiti: a prospective observational cohort study. AIDS Res Ther. 2010;7:33.PubMedCrossRefPubMedCentral
33.
go back to reference Kundu CK, Samanta M, Sarkar M, Bhattacharyya S, Chatterjee S. Food supplementation as an incentive to improve pre-antiretroviral therapy clinic adherence in HIV-positive children—experience from eastern India. J Trop Pediatr. 2012;58:31–7.PubMedCrossRef Kundu CK, Samanta M, Sarkar M, Bhattacharyya S, Chatterjee S. Food supplementation as an incentive to improve pre-antiretroviral therapy clinic adherence in HIV-positive children—experience from eastern India. J Trop Pediatr. 2012;58:31–7.PubMedCrossRef
34.
go back to reference Cantrell RA, Sinkala M, Megazinni K, et al. A pilot study of food supplementation to improve adherence to antiretroviral therapy among food-insecure adults in Lusaka, Zambia. J Acquir Immune Defic Syndr. 2008;49(2):190–5.PubMedCrossRef Cantrell RA, Sinkala M, Megazinni K, et al. A pilot study of food supplementation to improve adherence to antiretroviral therapy among food-insecure adults in Lusaka, Zambia. J Acquir Immune Defic Syndr. 2008;49(2):190–5.PubMedCrossRef
35.
go back to reference Serrano C, Laporte R, Ide M, Nouhou Y, de Truchis P, Rouveix E, Adamou A, Pauly V, Matteiand JF, Gastaut JAG. Family nutritional support improves survival, immune restoration and adherence in HIV patients receiving ART in developing country. Asia Pac J Clin Nutr. 2010;19:68–75.PubMed Serrano C, Laporte R, Ide M, Nouhou Y, de Truchis P, Rouveix E, Adamou A, Pauly V, Matteiand JF, Gastaut JAG. Family nutritional support improves survival, immune restoration and adherence in HIV patients receiving ART in developing country. Asia Pac J Clin Nutr. 2010;19:68–75.PubMed
36.
go back to reference Tirivayi N, Koethe JR, Groot W. Clinic-based food assistance is associated with increased medication adherence among HIV-infected adults on long-term antiretroviral therapy in Zambia. J AIDS Clin Res. 2012;3:171–8.PubMedCrossRefPubMedCentral Tirivayi N, Koethe JR, Groot W. Clinic-based food assistance is associated with increased medication adherence among HIV-infected adults on long-term antiretroviral therapy in Zambia. J AIDS Clin Res. 2012;3:171–8.PubMedCrossRefPubMedCentral
37.
go back to reference Posse M, Tirivayi N, Saha UR, Baltussen R. The effect of food assistance on adherence to antiretroviral therapy among HIV/AIDS patients in Sofala province, in Mozambique: a retrospective study. J AIDS Clin Res. 2013;4:198. doi:10.4172/2155-6113.1000198.CrossRef Posse M, Tirivayi N, Saha UR, Baltussen R. The effect of food assistance on adherence to antiretroviral therapy among HIV/AIDS patients in Sofala province, in Mozambique: a retrospective study. J AIDS Clin Res. 2013;4:198. doi:10.​4172/​2155-6113.​1000198.CrossRef
38.
go back to reference de Pee S, Grede N, Forsythe M, Bloem MW. Antiretroviral therapy requires life-long adherence. Lancet Infect Dis. 2012;12:661–2.PubMedCrossRef de Pee S, Grede N, Forsythe M, Bloem MW. Antiretroviral therapy requires life-long adherence. Lancet Infect Dis. 2012;12:661–2.PubMedCrossRef
39.
go back to reference Mehra D, de Pee S, Bloem MW. Nutrition, food security, social protection and health systems strengthening for HIV programming. In: Ivers L, editor. Food insecurity and public health. Boca Raton: CRC Press; 2014. Mehra D, de Pee S, Bloem MW. Nutrition, food security, social protection and health systems strengthening for HIV programming. In: Ivers L, editor. Food insecurity and public health. Boca Raton: CRC Press; 2014.
Metadata
Title
The Enabling Effect of Food Assistance in Improving Adherence and/or Treatment Completion for Antiretroviral Therapy and Tuberculosis Treatment: A Literature Review
Authors
Saskia de Pee
Nils Grede
Divya Mehra
Martin W. Bloem
Publication date
01-10-2014
Publisher
Springer US
Published in
AIDS and Behavior / Issue Special Issue 5/2014
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-014-0730-2

Other articles of this Special Issue 5/2014

AIDS and Behavior 5/2014 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.