Top

Published in:

Open Access 01-12-2022 | Review

The emerging role non-coding RNAs in B cell-related disorders

Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Elena Jamali

Published in: Cancer Cell International | Issue 1/2022

Abstract

Long non-coding RNAs and microRNAs have recently attained much attention regarding their role in the development of B cell lineage as well as participation in the lymphomagenesis. These transcripts have a highly cell type specific signature which endows them the potential to be used as biomarkers for clinical situations. Aberrant expression of several non-coding RNAs has been linked with B cell malignancies and immune related disorders such as rheumatoid arthritis, systemic lupus erythematous, asthma and graft-versus-host disease. Moreover, these transcripts can alter response of immune system to infectious conditions. miR-7, miR-16-1, miR-15a, miR-150, miR-146a, miR-155, miR-212 and miR-132 are among microRNAs whose role in the development of B cell-associated disorders has been investigated. Similarly, SNHG14, MALAT1, CRNDE, AL133346.1, NEAT1, SMAD5-AS1, OR3A4 and some other long non-coding RNAs participate in this process. In the current review, we describe the role of non-coding RNAs in B cell malignancies.

Hoffman W, Lakkis FG, Chalasani G. B Cells, Antibodies, and More. Clin J Am Soc Nephrol. 2016;11(1):137–54.PubMedCrossRef

Vale AM, Schroeder HW Jr. Clinical consequences of defects in B-cell development. J Allergy Clin Immunol. 2010;125(4):778–87.PubMedPubMedCentralCrossRef

Wuttke NJ, Macardle PJ, Zola H. Blood group antibodies are made by CD5+ and by CD5− B cells. Immunol Cell Biol. 1997;75(5):478–83.PubMedCrossRef

Suzuki K, Maruya M, Kawamoto S, Fagarasan S. Roles of B-1 and B-2 cells in innate and acquired IgA-mediated immunity. Immunol Rev. 2010;237(1):180–90.PubMedCrossRef

Zhang X, Wang W, Zhu W, Dong J, Cheng Y, Yin Z, et al. Mechanisms and functions of long non-coding RNAs at multiple regulatory levels. Int J Mol Sci. 2019;20(22):5573.PubMedCentralCrossRef

Liu K-S, Pan F, Mao X-D, Liu C, Chen Y-J. Biological functions of circular RNAs and their roles in occurrence of reproduction and gynecological diseases. Am J Transl Res. 2019;11(1):1–15.PubMedPubMedCentral

Macfarlane L-A, Murphy PR. MicroRNA: biogenesis, function and role in cancer. Curr Genomics. 2010;11(7):537–61.PubMedPubMedCentralCrossRef

Brazão TF, Johnson JS, Müller J, Heger A, Ponting CP, Tybulewicz VLJ. Long noncoding RNAs in B-cell development and activation. Blood. 2016;128(7):e10–9.PubMedPubMedCentralCrossRef

Wang M, Chen H, Qiu J, Yang H-X, Zhang C-Y, Fei Y-Y, et al. Antagonizing miR-7 suppresses B cell hyperresponsiveness and inhibits lupus development. J Autoimmunity. 2020;109:102440.CrossRef

10.

Tan LP, Wang M, Robertus J-L, Schakel RN, Gibcus JH, Diepstra A, et al. miRNA profiling of B-cell subsets: specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes. Lab Invest. 2009;89(6):708–16.PubMedCrossRef

11.

Tuncer SB, Akdeniz D, Celik B, Kilic S, Sukruoglu O, Avsar M, et al. The expression levels of miRNA-15a and miRNA-16-1 in circulating tumor cells of patients with diffuse large B-cell lymphoma. Mol Biol Rep. 2019;46(1):975–80.PubMedCrossRef

12.

Yang JM, Jang J-Y, Jeon YK, Paik JH. Clinicopathologic implication of microRNA-197 in diffuse large B cell lymphoma. J Transl Med. 2018;16(1):1–14.CrossRef

13.

Jiang Y, Zhou H, Ma D, Chen ZK, Cai X. MicroRNA-19a and CD22 comprise a feedback loop for B cell response in sepsis. Med Sci Monitor. 2015;21:1548.CrossRef

14.

Liu Y, Dong J, Mu R, Gao Y, Tan X, Li Y, et al. MicroRNA-30a promotes B cell hyperactivity in patients with systemic lupus erythematosus by direct interaction with Lyn. Arthritis Rheum. 2013;65(6):1603–11.PubMedCrossRef

15.

Alivernini S, Kurowska-Stolarska M, Tolusso B, Benvenuto R, Elmesmari A, Canestri S, et al. MicroRNA-155 influences B-cell function through PU1 in rheumatoid arthritis. Nat Commun. 2016;7(1):1–12.CrossRef

16.

Bedewy AM, Elmaghraby SM, Shehata AA, Kandil NS. Prognostic value of miRNA-155 expression in B-cell non-Hodgkin lymphoma. Turkish J Hematol. 2017;34(3):207.

17.

Sun W, Zhang L, Lin L, Wang W, Ge Y, Liu Y, et al. Chronic psychological stress impairs germinal center response by repressing miR-155. Brain Behav Immun. 2019;76:48–60.PubMedCrossRef

18.

Mo X, Wei F, Tong Y, Ding L, Zhu Q, Du S, et al. Lactic acid downregulates viral microRNA to promote Epstein-Barr Virus-immortalized B lymphoblastic cell adhesion and growth. J Virol. 2018;92(9):e00033-e118.PubMedPubMedCentralCrossRef

19.

Schneider C, Setty M, Holmes AB, Maute RL, Leslie CS, Mussolin L, et al. MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas. Proc Natl Acad Sci. 2014;111(22):8185–90.PubMedPubMedCentralCrossRef

20.

Harris-Arnold A, Arnold C, Schaffert S, Hatton O, Krams S, Esquivel C, et al. Epstein-Barr virus modulates host cell microrna-194 to promote il-10 production and B lymphoma cell survival. Am J Transplant. 2015;15(11):2814–24.PubMedCrossRef

21.

Gururajan M, Haga CL, Das S, Leu C-M, Hodson D, Josson S, et al. MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int Immunol. 2010;22(7):583–92.PubMedPubMedCentralCrossRef

22.

Liu S-H, Wang P-P, Cun-te-Chen DL, Liu Q-Y, Lv L, Liu X, et al. MicroRNA-148b enhances the radiosensitivity of B-cell lymphoma cells by targeting Bcl-w to promote apoptosis. Int J Biol Sci. 2020;16(6):935.PubMedPubMedCentralCrossRef

23.

Shim H, Nam J, Kim S-W. NF-κB p65 represses microRNA-124 transcription in diffuse large B-cell lymphoma. Genes Genom. 2020;42(5):543–51.CrossRef

24.

Yan S, Jia C, Quan L, Zhao L, Tian Y, Liu A. Significance of the microRNA-17-92 gene cluster expressed in B-cell non-Hodgkin’s lymphoma. Mol Med Rep. 2019;20(3):2459–67.PubMed

25.

Jabłońska E, Białopiotrowicz E, Szydłowski M, Prochorec-Sobieszek M, Juszczyński P, Szumera-Ciećkiewicz A. DEPTOR is a microRNA-155 target regulating migration and cytokine production in diffuse large B-cell lymphoma cells. Exp Hematol. 2020;88:56–67.PubMedCrossRef

26.

Su H, Chang J, Xu M, Sun R, Wang J. CDK6 overexpression resulted from microRNA-320d downregulation promotes cell proliferation in diffuse large B-cell lymphoma. Oncol Rep. 2019;42(1):321–7.PubMed

27.

Liu R-D, Zhuang W, Qi J-D, Li C-C. Expression and clinical significance of microRNA-195 in patients with diffuse large b cell lymphoma. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020;28(1):160–4.PubMed

28.

Due H, Schönherz AA, Ryø L, Primo MN, Jespersen DS, Thomsen EA, et al. MicroRNA-155 controls vincristine sensitivity and predicts superior clinical outcome in diffuse large B-cell lymphoma. Blood Adv. 2019;3(7):1185–96.PubMedPubMedCentralCrossRef

29.

Li Y-L, Tang J-M, Chen X-Y, Luo B, Liang G-H, Qu Q, et al. MicroRNA-153-3p enhances the sensitivity of chronic myeloid leukemia cells to imatinib by inhibiting B-cell lymphoma-2-mediated autophagy. Hum Cell. 2020;33(3):610–8.PubMedCrossRef

30.

Baraniskin A, Chomiak M, Ahle G, Gress T, Buchholz M, Turewicz M, et al. MicroRNA-30c as a novel diagnostic biomarker for primary and secondary B-cell lymphoma of the CNS. J Neurooncol. 2018;137(3):463–8.PubMedCrossRef

31.

Meng Y, Quan L, Liu A. Identification of key microRNAs associated with diffuse large B-cell lymphoma by analyzing serum microRNA expressions. Gene. 2018;642:205–11.PubMedCrossRef

32.

Wood CD, Carvell T, Gunnell A, Ojeniyi OO, Osborne C, West MJ. Enhancer control of microRNA miR-155 expression in Epstein-Barr virus-infected B cells. J Virol. 2018;92(19):e00716-e718.PubMedPubMedCentralCrossRef

33.

Tian L, Cao J, Ji Q, Zhang C, Qian T, Song X, et al. The downregulation of miR-3173 in B-cell acute lymphoblastic leukaemia promotes cell invasion via PTK2. Biochem Biophys Res Commun. 2017;494(3–4):569–74.PubMedCrossRef

34.

Labib HA, Elantouny NG, Ibrahim NF, Alnagar AA. Upregulation of microRNA-21 is a poor prognostic marker in patients with childhood B cell acute lymphoblastic leukemia. Hematology. 2017;22(7):392–7.PubMedCrossRef

35.

Song J, Shao Q, Li C, Liu H, Li J, Wang Y, et al. Effects of microRNA-21 on apoptosis by regulating the expression of PTEN in diffuse large B-cell lymphoma. Medicine. 2017;96:39.CrossRef

36.

Sun S, Wang H, Ji M. Overexpression of miR-222-3p promotes the proliferation and inhibits the apoptosis of diffuse large B-cell lymphoma cells via suppressing PPP2R2A. Technol Cancer Res Treat. 2019;18:1533033819892256.PubMedPubMedCentralCrossRef

37.

Shi X, Ye L, Xu S, Guo G, Zuo Z, Ye M, et al. Downregulated miR-29a promotes B cell overactivation by upregulating Crk-like protein in systemic lupus erythematosus. Mol Med Rep. 2020;22(2):841–9.PubMedPubMedCentralCrossRef

38.

Wang X, Wen X, Zhou J, Qi Y, Wu R, Wang Y, et al. MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients. PLoS ONE. 2017;12(9):e0184292.PubMedPubMedCentralCrossRef

39.

Karkhanis V, Alinari L, Ozer HG, Chung J, Zhang X, Sif S, et al. Protein arginine methyltransferase 5 represses tumor suppressor miRNAs that down-regulate CYCLIN D1 and c-MYC expression in aggressive B-cell lymphoma. J Biol Chem. 2020;295(5):1165–80.PubMedCrossRef

40.

Sun J-R, Zhang X, Zhang Y. MiR-214 prevents the progression of diffuse large B-cell lymphoma by targeting PD-L1. Cell Mol Biol Lett. 2019;24(1):1–13.CrossRef

41.

Zhang Z-W, Wang M, Hu J-J, Xu G, Zhang Y, Zhang N. Decreased expression of microRNA-107 in B lymphocytes of patients with antibody-mediated renal allograft rejection. Tohoku J Exp Med. 2018;246(2):87–96.PubMedCrossRef

42.

Romero M, Gapihan G, Castro-Vega LJ, Acevedo A, Wang L, Li ZW, et al. Primary mediastinal large B-cell lymphoma: Transcriptional regulation by miR-92a through FOXP1 targeting. Oncotarget. 2017;8(10):16243.PubMedCrossRef

43.

Chen L, Zhan C-Z, Wang T, You H, Yao R. Curcumin inhibits the proliferation, migration, invasion, and apoptosis of diffuse large B-cell lymphoma cell line by regulating MiR-21/VHL axis. Yonsei Med J. 2020;61(1):20–9.PubMedCrossRef

44.

Han B, Gao Z-D, Wang H-X, Wang Z-H, Fan C-B, Liu J-L, et al. Expression of MiR-155 in tissue of patients with diffuse large B-cell lymphoma and its effect on cell biological characteristics. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019;27(2):445–51.PubMed

45.

Wu R-J, Zou Y, Ma X-D, Zheng R-J. Expression and clinical significance of MiR-215 and KDM1B in patients with diffuse large B cell lymphoma. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020;28(5):1570–7.PubMed

46.

Farroni C, Marasco E, Marcellini V, Giorda E, Valentini D, Petrini S, et al. Dysregulated miR-155 and miR-125b are related to impaired B-cell responses in Down syndrome. Front Immunol. 2018;9:2683.PubMedPubMedCentralCrossRef

47.

Chen L, Xu J, Chu X, Ju C. MicroRNA-98 interferes with thrombospondin 1 expression in peripheral B cells of patients with asthma. Biosci Rep. 2017;37(4):BSR20170149.PubMedPubMedCentralCrossRef

48.

Kang T, Sun W-L, Lu X-F, Wang X-L, Jiang L. MiR-28-5p mediates the anti-proliferative and pro-apoptotic effects of curcumin on human diffuse large B-cell lymphoma cells. J Int Med Res. 2020;48(7):0300060520943792.PubMedCentralCrossRef

49.

Asker HA, Khorshed EN, Ahmed MR, Refaat LA, Khaled HM, Rashed RA. Prognostic Values of MicroRNA-21 and Ki-67 in diffuse large B-cell lymphoma patients: Egyptian experience. Clin Lab. 2021;67:7.CrossRef

50.

Fan Q, Meng X, Liang H, Zhang H, Liu X, Li L, et al. miR-10a inhibits cell proliferation and promotes cell apoptosis by targeting BCL6 in diffuse large B-cell lymphoma. Protein Cell. 2016;7(12):899–912.PubMedPubMedCentralCrossRef

51.

Shen M, Wang Y, Cui S, Wu X, Guo Y, Xu R. MicroRNA-125a regulates proliferation and apoptosis of acute myeloid leukemia through targeting NF-κB pathway. Eur Rev Med Pharmacol Sci. 2019;23:3594–601.PubMed

52.

Wang Y, Jia X, Zhou L, Yin J, Zhao Y, Dai L, et al. Increased let-7b-5p is associated with enhanced BAFF-R expression and B cell survival in immune thrombocytopenia. Int Immunopharmacol. 2021;93:107393.PubMedCrossRef

53.

Luo Y, Yang J, Zhang C, Jin Y, Pan H, Liu L, et al. Up-regulation of miR-27a promotes monocyte-mediated inflammatory responses in Kawasaki disease by inhibiting function of B10 cells. J Leukoc Biol. 2020;107(1):133–44.PubMedCrossRef

54.

Benhamou D, Labi V, Getahun A, Benchetrit E, Dowery R, Rajewsky K, et al. The c-Myc/miR17-92/PTEN axis tunes PI3K activity to control expression of recombination activating genes in early B cell development. Front Immunol. 2018;9:2715.PubMedPubMedCentralCrossRef

55.

Zhang S, Wang L, Cheng L. Aberrant ERG expression associates with downregulation of miR-4638-5p and selected genomic alterations in a subset of diffuse large B-cell lymphoma. Mol Carcinog. 2019;58(10):1846–54.PubMedCrossRef

56.

Huang Q, Zhang F, Fu H, Shen J. Epigenetic regulation of miR-518a-5p-CCR6 feedback loop promotes both proliferation and invasion in diffuse large B cell lymphoma. Epigenetics. 2021;16(1):28–44.PubMedCrossRef

57.

Liu X-S, Wang X-C, Ding K-Y, Wu Q. Expression of MiR-296-5p in diffuse large B-Cell lymphoma and its influence on biological behavior of tumor cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018;26(2):437–42.PubMed

58.

Liu Y-P, Hu H, Xu F, Wen J-J. Relation of miR-34a expression in diffuse large B cell lymphoma with clinical prognosis. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25(2):455–9.PubMed

59.

Xie Y, Tan L, Li Y-T, Zeng Y. Mechanism of MiR-224 Affecting DLBCL Cell Proliferation and Invasion by Targeted Inhibition of PIK3CD. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2020;28(5):1578–84.PubMed

60.

Xiao X, Gu Y, Sun D, Ding L, Yuan X, Jiang H, et al. Effect of rituximab combined with chemotherapy on the expression of serum exosome miR-451a in patients with diffuse large b-cell lymphoma. Eur Rev Med Pharmacol Sci. 2019;23(4):1620–5.PubMed

61.

Luo S, Ding S, Liao J, Zhang P, Liu Y, Zhao M, et al. Excessive miR-152-3p results in increased BAFF expression in SLE B-cells by inhibiting the KLF5 expression. Front Immunol. 2019;10:1127.PubMedPubMedCentralCrossRef

62.

Bartolomé-Izquierdo N, de Yébenes VG, Alvarez-Prado AF, Mur SM, Olmo JA, Roa S, et al. miR-28 regulates the germinal center reaction and blocks tumor growth in preclinical models of non-Hodgkin lymphoma. Blood J Am Soc Hematol. 2017;129(17):2408–19.

63.

Song J, Su W, Chen X, Zhao Q, Zhang N, Li M-G, et al. Micro RNA-98 suppresses interleukin-10 in peripheral B cells in patient post-cardio transplantation. Oncotarget. 2017;8(17):28237.PubMedPubMedCentralCrossRef

64.

Yuan Y, Niu F, Nolte IM, Koerts J, de Jong D, Rutgers B, et al. MicroRNA high throughput loss-of-function screening reveals an oncogenic role for miR-21-5p in Hodgkin lymphoma. Cell Physiol Biochem. 2018;49(1):144–59.PubMedCrossRef

65.

van Nieuwenhuijze A, Dooley J, Humblet-Baron S, Sreenivasan J, Koenders M, Schlenner SM, et al. Defective germinal center B-cell response and reduced arthritic pathology in microRNA-29a-deficient mice. Cell Mol Life Sci. 2017;74(11):2095–106.PubMedCrossRef

66.

Okuyama K, Ikawa T, Gentner B, Hozumi K, Harnprasopwat R, Lu J, et al. MicroRNA-126–mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors. Proc Natl Acad Sci. 2013;110(33):13410–5.PubMedPubMedCentralCrossRef

67.

Mehta A, Mann M, Zhao JL, Marinov GK, Majumdar D, Garcia-Flores Y, et al. The microRNA-212/132 cluster regulates B cell development by targeting Sox4. J Exp Med. 2015;212(10):1679–92.PubMedPubMedCentralCrossRef

68.

Kurkewich JL, Bikorimana E, Nguyen T, Klopfenstein N, Zhang H, Hallas WM, et al. The mirn23a microRNA cluster antagonizes B cell development. J Leukoc Biol. 2016;100(4):665–77.PubMedCrossRef

69.

Gonzalez-Martin A, Adams BD, Lai M, Shepherd J, Salvador-Bernaldez M, Salvador JM, et al. The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity. Nat Immunol. 2016;17(4):433–40.PubMedPubMedCentralCrossRef

70.

Wu Y, Schutt S, Paz K, Zhang M, Flynn RP, Bastian D, et al. MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice. Blood. 2018;131(17):1974–86.PubMedPubMedCentralCrossRef

71.

Li G, Soll AY-L, Sookram R, Wong S, Wang JK, Ouyang Y, et al. Epigenetic silencing of miR-125b is required for normal B-cell development. Blood. 2018;131(17):1920–30.PubMedPubMedCentralCrossRef

72.

Farina FM, Inguscio A, Kunderfranco P, Cortesi A, Elia L, Quintavalle M. MicroRNA-26a/cyclin-dependent kinase 5 axis controls proliferation, apoptosis and in vivo tumor growth of diffuse large B-cell lymphoma cell lines. Cell Death Dis. 2017;8(6):e2890.PubMedPubMedCentralCrossRef

73.

Arbore G, Henley T, Biggins L, Andrews S, Vigorito E, Turner M, et al. MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells. Life Sci Alliance. 2019;2:3.CrossRef

74.

Glaesener S, Jaenke C, Habener A, Geffers R, Hagendorff P, Witzlau K, et al. Decreased production of class-switched antibodies in neonatal B cells is associated with increased expression of miR-181b. PLoS ONE. 2018;13(2):e0192230.PubMedPubMedCentralCrossRef

75.

Petkau G, Kawano Y, Wolf I, Knoll M, Melchers F. MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice. Eur J Immunol. 2018;48(6):975–89.PubMedCrossRef

76.

Wang W, Wang J, Yan M, Jiang J, Bian A. MiRNA-92a protects pancreatic B-cell function by targeting KLF2 in diabetes mellitus. Biochem Biophys Res Commun. 2018;500(3):577–82.PubMedCrossRef

77.

Sewastianik T, Straubhaar JR, Zhao J-J, Samur MK, Adler K, Tanton HE, et al. miR-15a/16-1 deletion in activated B cells promotes plasma cell and mature B-cell neoplasms. Blood. 2021;137(14):1905–19.PubMedPubMedCentralCrossRef

78.

Cho S, Lee H-M, Yu I-S, Choi YS, Huang H-Y, Hashemifar SS, et al. Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun. 2018;9(1):1–13.CrossRef

79.

Contreras JR, Palanichamy JK, Tran TM, Fernando TR, Rodriguez-Malave NI, Goswami N, et al. MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1. Oncotarget. 2015;6(13):11023.PubMedPubMedCentralCrossRef

80.

Li S, He X, Gan Y, Zhang J, Gao F, Lin L, et al. Targeting miR-21 with NL101 blocks c-Myc/Mxd1 loop and inhibits the growth of B cell lymphoma. Theranostics. 2021;11(7):3439.PubMedPubMedCentralCrossRef

81.

Amrouche L, You S, Sauvaget V, Manda V, Lamarthée B, Desbuissons G, et al. MicroRNA-146a-deficient mice develop immune complex glomerulonephritis. Sci Rep. 2019;9(1):1–13.CrossRef

82.

Li F, Huang Y, Huang Y-Y, Kuang Y-S, Wei Y-J, Xiang L, et al. MicroRNA-146a promotes IgE class switch in B cells via upregulating 14-3-3σ expression. Mol Immunol. 2017;92:180–9.PubMedCrossRef

83.

Kuriyama K, Enomoto Y, Suzuki R, Watanuki J, Hosoi H, Yamashita Y, et al. Enforced expression of MIR142, a target of chromosome translocation in human B-cell tumors, results in B-cell depletion. Int J Hematol. 2018;107(3):345–54.PubMedCrossRef

84.

Chen X, Dong S, Zhang N, Chen L, Li M-G, Yang P-C, et al. MicroRNA-98 plays a critical role in experimental myocarditis. Int J Cardiol. 2017;229:75–81.PubMedCrossRef

85.

Jiang S, Yan W, Wang SE, Baltimore D. Let-7 suppresses B cell activation through restricting the availability of necessary nutrients. Cell Metab. 2018;27(2):393–403.PubMedCrossRef

86.

Xiao S, Zhang W, Manley NR. Thymic epithelial cell-derived signals control B progenitor formation and proliferation in the thymus by regulating Let-7 and Arid3a. PLoS ONE. 2018;13(2):e0193188.PubMedPubMedCentralCrossRef

87.

Blume J, Ziętara N, Witzlau K, Liu Y, Sanchez OO, Puchałka J, et al. miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1. Eur J Immunol. 2019;49(1):121–32.PubMedCrossRef

88.

Lindner SE, Lohmüller M, Kotkamp B, Schuler F, Knust Z, Villunger A, et al. The miR-15 family reinforces the transition from proliferation to differentiation in pre-B cells. EMBO Rep. 2017;18(9):1604–17.PubMedPubMedCentralCrossRef

89.

Kurkewich JL, Hansen J, Klopfenstein N, Zhang H, Wood C, Boucher A, et al. The miR-23a~ 27a–24–2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis. PLoS Genetics. 2017;13(7):e1006887.PubMedPubMedCentralCrossRef

90.

Zhao L, Liu Y, Zhang J, Liu Y, Qi Q. LncRNA SNHG14/miR-5590-3p/ZEB1 positive feedback loop promoted diffuse large B cell lymphoma progression and immune evasion through regulating PD-1/PD-L1 checkpoint. Cell Death Dis. 2019;10(10):1–15.CrossRef

91.

Wang Q-M, Lian G-Y, Song Y, Huang Y-F, Gong Y. LncRNA MALAT1 promotes tumorigenesis and immune escape of diffuse large B cell lymphoma by sponging miR-195. Life Sci. 2019;231:116335.PubMedCrossRef

92.

Qian C-S, Li L-J, Huang H-W, Yang H-F, Wu D-P. MYC-regulated lncRNA NEAT1 promotes B cell proliferation and lymphomagenesis via the miR-34b-5p-GLI1 pathway in diffuse large B-cell lymphoma. Cancer Cell Int. 2020;20(1):1–13.CrossRef

93.

Wang W, Wu F, Ma P, Gan S, Li X, Chen L, et al. LncRNA CRNDE promotes the progression of B-cell precursor acute lymphoblastic leukemia by targeting the miR-345-5p/CREB Axi. Mol Cells. 2020;43(8):718.PubMedPubMedCentral

94.

Cuadros M, García DJ, Andrades A, Arenas AM, Coira IF, Baliñas-Gavira C, et al. LncRNA-mRNA co-expression analysis identifies AL1333461/CCN2 as biomarkers in pediatric B-cell acute lymphoblastic leukemia. Cancers. 2020;12(12):3803.PubMedCentralCrossRef

95.

Bi M, Shi J, Zhao Y, Li C. LncRNA PTTG3P induced aberrant glycosylated IgA1 production and B cell growth in IgA nephropathy. Environ Sci Pollut Res. 2021;1:1–9.

96.

Ghoveud E, Teimuri S, Vatandoost J, Hosseini A, Ghaedi K, Etemadifar M, et al. Potential biomarker and therapeutic LncRNAs in multiple sclerosis through targeting memory B cells. NeuroMol Med. 2020;22(1):111–20.CrossRef

97.

Zhao C-C, Jiao Y, Zhang Y-Y, Ning J, Zhang Y-R, Xu J, et al. Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC. Cell Death Dis. 2019;10(4):1–15.CrossRef

98.

Meng H, Zhao B, Wang Y. FOXM1-induced upregulation of lncRNA OR3A4 promotes the progression of diffuse large B-cell lymphoma via Wnt/β-catenin signaling pathway. Exp Mol Pathol. 2020;115:104451.PubMedCrossRef

99.

Shi X, Cui Z, Liu X, Wu S, Wu Y, Fang F, et al. LncRNA FIRRE is activated by MYC and promotes the development of diffuse large B-cell lymphoma via Wnt/β-catenin signaling pathway. Biochem Biophys Res Commun. 2019;510(4):594–600.PubMedCrossRef

100.

Tang J-L, Li X-M, Zhang L. Expression and significance of lncRNA RP11–513G11.1 in peripheral blood of patients with diffuse large B-cell lymphoma. Zhongguo shi yan xue ye xue za zhi. 2019;27(5):1515–21.PubMed

101.

Wang F, Luo Y, Zhang L, Younis M, Yuan L. Down-regulation of LncRNA 2900052N01Rik inhibits LPS-induced B cell function in vitro. Cell Immunol. 2021;363:104321.PubMedCrossRef

102.

Li Q, Li B, Lu C-L, Wang J-Y, Gao M, Gao W. LncRNA LINC01857 promotes cell growth and diminishes apoptosis via PI3K/mTOR pathway and EMT process by regulating miR-141-3p/MAP4K4 axis in diffuse large B-cell lymphoma. Cancer Gene Ther. 2021;28(9):1046–57.PubMedCrossRef

103.

Orlandella FM, Smaldone G, Salvatore G, Vitagliano L, Cianflone A, Parasole R, et al. The lncRNA TEX41 is upregulated in pediatric B-cells acute lymphoblastic leukemia and it is necessary for leukemic cell growth. Biomarker Res. 2021;9(1):1–11.CrossRef

104.

Gao H, Sun Y, Chen J, Jin H, Yang W. Long non-coding RNA AFAP1-AS1 promotes cell growth and inhibits apoptosis by binding to specific proteins in germinal center B-cell-like diffuse large B-cell lymphoma. Am J Transl Res. 2020;12(12):8225.PubMedPubMedCentral

105.

Yu B, Wang B, Wu Z, Wu C, Ling J, Gao X, et al. LncRNA SNHG8 promotes proliferation and inhibits apoptosis of diffuse large B-cell lymphoma via sponging miR-335–5p. Front Oncol. 2021;11:1.

106.

Sheng Y, Fan C, Zhang W. LncRNA PCAT1 enhances cell proliferation, migration and invasion by miR-508-3p/NFIB axis in diffuse large B-cell lymphoma. Eur Rev Med Pharmacol Sci. 2021;25:2567–76.PubMed

107.

Fu D-W, Liu A-C. LncRNA SBF2-AS1 promotes diffuse large B-cell lymphoma growth by regulating FGFR2 via sponging miR-494-3p. Cancer Manag Res. 2021;13:571.PubMedPubMedCentralCrossRef

108.

Tian Y, Li L, Lin G, Wang Y, Wang L, Zhao Q, et al. lncRNA SNHG14 promotes oncogenesis and immune evasion in diffuse large-B-cell lymphoma by sequestering miR-152–3p. Leukemia Lymphoma. 2021;1:1–15.

109.

Zeng H, Wei Y, Wei X, Feng R. LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p. Cancer Manag Res. 2021;13:3589.PubMedPubMedCentralCrossRef

110.

Jiang X, Wang Y, Li X, He L, Yang Q, Wang W, et al. Microarray profile of B cells from Graves’ disease patients reveals biomarkers of proliferation. Endocr Connect. 2020;9(5):405–17.PubMedPubMedCentralCrossRef

111.

Wang Q, Du X, Yang M, Xiao S, Cao J, Song J, et al. LncRNA ZEB1-AS1 contributes to STAT3 activation by associating with IL-11 in B-lymphoblastic leukemia. Biotech Lett. 2017;39(12):1801–10.CrossRef

112.

Zhang M, Du Y, Shang J, Zhang D, Dong X, Chen H. Knockdown of UCA1 restrains cell proliferation and metastasis of diffuse large B-cell lymphoma by counteracting miR-331-3p expression. Oncol Lett. 2021;21(1):1.

113.

Wang W-T, Chen T-Q, Zeng Z-C, Pan Q, Huang W, Han C, et al. The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. J Hematol Oncol. 2020;13(1):1–19.PubMedPubMedCentralCrossRef

114.

Mao Y, Tie Y, Du J, He J. LINC00152 promotes the proliferation of gastric cancer cells by regulating B-cell lymphoma-2. J Cell Biochem. 2019;120(3):3747–56.PubMedCrossRef

115.

Hu L, Zhao J, Liu Y, Liu X, Lu Q, Zeng Z, et al. Geniposide inhibits proliferation and induces apoptosis of diffuse large B-cell lymphoma cells by inactivating the HCP5/miR-27b-3p/MET axis. Int J Med Sci. 2020;17(17):2735.PubMedPubMedCentralCrossRef

116.

Zhao J, Su L, Jiang J. Long non-coding RNA paternally expressed imprinted gene 10 (PEG10) elevates diffuse large B-cell lymphoma progression by regulating kinesin family member 2A (KIF2A) via Targeting MiR-101-3p. Med Sci Monitor. 2020;26:e922810–1.CrossRef

117.

Miao Y, Chen X, Qin M, Zhou W, Wang Y, Ji Y. lncRNA GAS5, as a ceRNA, inhibits the proliferation of diffuse large B-cell lymphoma cells by regulating the miR-18a-5p/RUNX1 axis. Int J Oncol. 2021;59(5):1–12.CrossRef

118.

Cheng H, Yan Z, Wang X, Cao J, Chen W, Qi K, et al. Downregulation of long non-coding RNA TUG1 suppresses tumor growth by promoting ubiquitination of MET in diffuse large B-cell lymphoma. Mol Cell Biochem. 2019;461(1):47–56.PubMedCrossRef

119.

Chen L-Y, Zhang X-M, Han B-Q, Dai H-B. Long noncoding RNA SNHG12 indicates the prognosis and accelerates tumorigenesis of diffuse large B-cell lymphoma through sponging microR-195. Onco Targets Ther. 2020;13:5563.PubMedPubMedCentralCrossRef

120.

Wang Y, Zhang M, Xu H, Wang Y, Li Z, Chang Y, et al. Discovery and validation of the tumor-suppressive function of long noncoding RNA PANDA in human diffuse large B-cell lymphoma through the inactivation of MAPK/ERK signaling pathway. Oncotarget. 2017;8(42):72182.PubMedPubMedCentralCrossRef

121.

Jing Z, Gao L, Wang H, Chen J, Nie B, Hong Q. Long non-coding RNA GAS5 regulates human B lymphocytic leukaemia tumourigenesis and metastasis by sponging miR-222. Cancer Biomark. 2019;26(3):385–92.PubMedCrossRef

122.

Song Y, Gao F, Peng Y, Yang X. Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13. Cell Biol Int. 2020;44(6):1331–40.PubMedCrossRef

123.

Hu G, Gupta SK, Troska TP, Nair A, Gupta M. Long non-coding RNA profile in mantle cell lymphoma identifies a functional lncRNA ROR1-AS1 associated with EZH2/PRC2 complex. Oncotarget. 2017;8(46):80223.PubMedPubMedCentralCrossRef

124.

Zhang S, Wan H, Zhang X. LncRNA LHFPL3-AS1 contributes to tumorigenesis of melanoma stem cells via the miR-181a-5p/BCL2 pathway. Cell Death Dis. 2020;11(11):1–16.PubMedPubMedCentralCrossRef

125.

Zhao S, Fang S, Liu Y, Li X, Liao S, Chen J, et al. The long non-coding RNA NONHSAG026900 predicts prognosis as a favorable biomarker in patients with diffuse large B-cell lymphoma. Oncotarget. 2017;8(21):34374.PubMedPubMedCentralCrossRef

126.

Zhu Q, Li Y, Guo Y, Hu L, Xiao Z, Liu X, et al. Long non-coding RNA SNHG16 promotes proliferation and inhibits apoptosis of diffuse large B-cell lymphoma cells by targeting miR-497-5p/PIM1 axis. J Cell Mol Med. 2019;23(11):7395–405.PubMedPubMedCentralCrossRef

127.

Deng L, Jiang L, Tseng K-F, Liu Y, Zhang X, Dong R, et al. Aberrant NEAT1_1 expression may be a predictive marker of poor prognosis in diffuse large B cell lymphoma. Cancer Biomark. 2018;23(2):157–64.PubMedCrossRef

128.

Li Y, Jia Z, Zhao H, Liu X, Luo J, Cui G, et al. TUC338 Promotes Diffuse Large B Cell Lymphoma Growth via Regulating EGFR/PI3K/AKT Signaling Pathway. J Oncol. 2021;2021:1.

129.

Huang Y, Lin Y, Song X, Wu D. LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma. Carcinogenesis. 2021;42(5):733–41.PubMedCrossRef

130.

El-Khazragy N, Esmaiel MA, Mohamed MM, Hassan NS. Upregulation of long noncoding RNA Lnc-IRF2-3 and Lnc-ZNF667-AS1 is associated with poor survival in B-chronic lymphocytic leukemia. Int J Lab Hematol. 2020;42(3):284–91.PubMedCrossRef

131.

Cui Y, Xu H, Yang Y, Zhao D, Wen Y, Lv C, et al. The regulation of miR-320a/XBP1 axis through LINC00963 for endoplasmic reticulum stress and autophagy in diffuse large B-cell lymphoma. Cancer Cell Int. 2021;21(1):1–13.CrossRef

132.

Du X, Liu H, Yang C, Shi X, Cao L, Zhao X, et al. LncRNA landscape analysis identified LncRNA LEF-AS1 as an oncogene that upregulates LEF1 and promotes survival in chronic lymphocytic leukemia. Leukemia Res. 2021;110:106706.CrossRef

133.

Handa H, Honma K, Oda T, Kobayashi N, Kuroda Y, Kimura-Masuda K, et al. Long noncoding RNA PVT1 is regulated by bromodomain protein BRD4 in multiple myeloma and is associated with disease progression. Int J Mol Sci. 2020;21(19):7121.PubMedCentralCrossRef

134.

Fernando TR, Rodriguez-Malave NI, Waters EV, Yan W, Casero D, Basso G, et al. LncRNA expression discriminates karyotype and predicts survival in B-lymphoblastic leukemia. Mol Cancer Res. 2015;13(5):839–51.PubMedPubMedCentralCrossRef

135.

Sehgal L, Mathur R, Braun FK, Wise JF, Berkova Z, Neelapu S, et al. FAS-antisense 1 lncRNA and production of soluble versus membrane Fas in B-cell lymphoma. Leukemia. 2014;28(12):2376–87.PubMedPubMedCentralCrossRef

136.

Peng W, Feng J. Long noncoding RNA LUNAR1 associates with cell proliferation and predicts a poor prognosis in diffuse large B-cell lymphoma. Biomed Pharmacother. 2016;77:65–71.PubMedCrossRef

137.

Yan Y, Han J, Li Z, Yang H, Sui Y, Wang M. Elevated RNA expression of long non-coding HOTAIR promotes cell proliferation and predicts a poor prognosis in patients with diffuse large B cell lymphoma. Mol Med Rep. 2016;13(6):5125–31.PubMedPubMedCentralCrossRef

138.

Peng W, Fan H, Wu G, Wu J, Feng J. Upregulation of long noncoding RNA PEG10 associates with poor prognosis in diffuse large B cell lymphoma with facilitating tumorigenicity. Clin Exp Med. 2016;16(2):177–82.PubMedCrossRef

139.

Peng W, Wu J, Feng J. Long noncoding RNA HULC predicts poor clinical outcome and represents pro-oncogenic activity in diffuse large B-cell lymphoma. Biomed Pharmacother. 2016;79:188–93.PubMedCrossRef

140.

Peng W, Wu J, Feng J. LincRNA-p21 predicts favorable clinical outcome and impairs tumorigenesis in diffuse large B cell lymphoma patients treated with R-CHOP chemotherapy. Clin Exp Med. 2017;17(1):1–8.PubMedCrossRef

141.

Rodríguez-Malavé NI, Fernando TR, Patel PC, Contreras JR, Palanichamy JK, Tran TM, et al. BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia. Mol Cancer. 2015;14(1):1–15.CrossRef

142.

Wang F, Luo Y, Zhang L, Younis M, Yuan L. The LncRNA RP1.1–301G191/miR-582–5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway. Cancer Gene Therapy. 2021;1:1–12.

143.

Hu T, Gao Y. β-elemene suppresses tumor growth of diffuse large B-cell lymphoma through regulating lncRNA HULC-mediated apoptotic pathway. Biosci Rep. 2020;40(2):20190804.CrossRef

144.

Wang F, Cui D, Zhang Q, Shao Y, Zheng B, Chen L, et al. LncRNA00492 is required for marginal zone B-cell development. Immunology. 2021;165(1):88–98.PubMedCrossRef

145.

Li L-J, Chai Y, Guo X-J, Chu S-L, Zhang L-S. The effects of the long non-coding RNA MALAT-1 regulated autophagy-related signaling pathway on chemotherapy resistance in diffuse large B-cell lymphoma. Biomed Pharmacother. 2017;89:939–48.PubMedCrossRef

146.

Dong G, Yang Y, Li X, Yao X, Zhu Y, Zhang H, et al. Granulocytic myeloid-derived suppressor cells contribute to IFN-I signaling activation of B cells and disease progression through the lncRNA NEAT1-BAFF axis in systemic lupus erythematosus. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease. 2020;1866(1):165554.

147.

Liu W, Lei L, Liu X, Ye S. CircRNA_OTUD7A upregulates FOXP1 expression to facilitate the progression of diffuse large B-cell lymphoma via acting as a sponge of miR-431-5p. Genes & Genomics. 2021;43(6):653–67.CrossRef

148.

Chen X, Xie X, Zhou W. CircCFL1/MiR-107 axis targeting HMGB1 promotes the malignant progression of diffuse large B-cell lymphoma tumors. Cancer Manag Res. 2020;12:9351.PubMedPubMedCentralCrossRef

149.

Hu Y, Zhao Y, Shi C, Ren P, Wei B, Guo Y, et al. A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/β-catenin signaling via interacting with TET1 and miR-888. Aging (Albany NY). 2019;11(19):8068.CrossRef

150.

Wu W, Wu Z, Xia Y, Qin S, Li Y, Wu J, et al. Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis. Aging (Albany NY). 2019;11(11):3561.CrossRef

151.

Lux S, Blätte TJ, Gillissen B, Richter A, Cocciardi S, Skambraks S, et al. Deregulated expression of circular RNAs in acute myeloid leukemia. Blood Adv. 2021;5(5):1490–503.PubMedPubMedCentralCrossRef

152.

Mei M, Wang Y, Wang Q, Liu Y, Song W, Zhang M. CircCDYL serves as a new biomarker in mantle cell lymphoma and promotes cell proliferation. Cancer Manag Res. 2019;11:10215.PubMedPubMedCentralCrossRef

153.

Li Q, Luan Q, Zhu H, Zhao Y, Ji J, Wu F, et al. Circular RNA circ_0005774 contributes to proliferation and suppresses apoptosis of acute myeloid leukemia cells via circ_0005774/miR-192–5p/ULK1 ceRNA pathway. Biochem Biophys Res Commun. 2021;551:78–85.PubMedCrossRef

154.

Ma X, Xiang F, Pei Z, Miao J, Wu P, Song X, et al. Circ-Smad5 retards the G1/S transition of cell cycle via inhibiting the activity of wnt/lef/cyclind1 signaling in JB6 cells. Genes Dis. 2021;8(3):364–72.PubMedCrossRef

155.

Wang D, Ming X, Xu J, Xiao Y. Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis. Hematol Oncol. 2021;39(3):390–400.PubMedCrossRef

156.

Xia L, Wu L, Bao J, Li Q, Chen X, Xia H, et al. Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway. Biochem Biophys Res Commun. 2018;503(1):385–90.PubMedCrossRef

157.

Winkle M, Kluiver J, Diepstra A, van den Berg A. Emerging roles for long noncoding RNAs in B-cell development and malignancy. Crit Rev Oncol Hematol. 2017;120:77–85.PubMedCrossRef

Title: The emerging role non-coding RNAs in B cell-related disorders
Authors: Soudeh Ghafouri-Fard
Tayyebeh Khoshbakht
Bashdar Mahmud Hussen
Mohammad Taheri
Elena Jamali
Publication date: 01-12-2022
Publisher: BioMed Central
Published in: Cancer Cell International / Issue 1/2022
Electronic ISSN: 1475-2867
DOI: https://doi.org/10.1186/s12935-022-02521-1

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2022

Multi-omics analysis revealed TEK and AXIN2 are potential biomarkers in multifocal papillary thyroid cancer

Comprehensive analysis of the prognostic implications and functional exploration of PAK gene family in human cancer

Potential mechanisms of quercetin in cancer prevention: focus on cellular and molecular targets

LINC00665 up-regulates SIN3A expression to modulate the progression of colorectal cancer via sponging miR-138-5p

Identification of icaritin derivative IC2 as an SCD-1 inhibitor with anti-breast cancer properties through induction of cell apoptosis

CRISPR/Cas9 system in breast cancer therapy: advancement, limitations and future scope

Keynote webinar | Spotlight on antibody–drug conjugates in cancer