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01-09-2014 | Original Article

The effects of a minimally invasive laser needle system on complete Freund’s adjuvant-induced arthritis

Authors: Heesung Kang, Taeyoon Son, Aeju Lee, Inchan Youn, Dong Hyun Seo, Han Sung Kim, Byungjo Jung

Published in: Lasers in Medical Science | Issue 5/2014

Abstract

The present study aimed to investigate the effects of a minimally invasive laser needle system (MILNS) on the acute progression of arthritis. Previous studies showed controversial clinical results regarding the effects of low-level laser therapy on arthritis, with the outcomes depending upon stimulation parameters such as laser wavelength and dosage. Based on the positive effects of MILNS on osteoporotic mice, we hypothesized that MILNS could potentially suppress the progression of arthritis owing to its biostimulation effects. Eight C57BL/6 mice with complete Freund’s adjuvant (CFA)-induced arthritis were used as acute progression arthritis models and divided into the laser and control groups (n = 4 each). In the laser group, after minimally invasive laser stimulation, laser speckle contrast images (LSCIs) were obtained every 6 h for a total of 108 h. The LSCIs in the control group were obtained without laser stimulation. The effects of MILNS on the acute progression of arthritis were indirectly evaluated by calculating the paw area and the average laser speckle index (LSI) at the arthritis-induced area. Moreover, the macrophage population was estimated in the arthritis-induced area. Compared to the control group, the laser group showed (1) lower relative variations of the paw area, (2) lower average LSI in the arthritis-induced area, and (3) lower macrophage population in the arthritis-induced area. These results indicate that MILNS may suppress the acute progression of CFA-induced arthritis in mice and may thus be used as a potential treatment modality of arthritis in clinics.

Basford JR (1995) Low intensity laser therapy: still not an established clinical tool. Lasers Surg Med 16(4):331–342PubMedCrossRef

Johannsen F, Hauschild B, Remvig L, Johnsen V, Petersen M, Bieler T (1994) Low energy laser therapy in rheumatoid arthritis. Scand J Rheumatol 23(3):145–147PubMedCrossRef

Alves AC, de Carvalho PT, Parente M, Xavier M, Frigo L, Aimbire F, Leal EC Jr, Albertini R (2013) Low-level laser therapy in different stages of rheumatoid arthritis: a histological study. Lasers Med Sci 28(2):529–536. doi:10.1007/s10103-012-1102-7 PubMedCrossRef

Goats GC, Hunter JA, Flett E, Stirling A (1996) Low intensity laser and phototherapy for rheumatoid arthritis. Physiotherapy 82(5):311–320CrossRef

Brosseau L, Robinson V, Wells G, Debie R, Gam A, Harman K, Morin M, Shea B, Tugwell P (2005) Low level laser therapy (classes I, II and III) for treating rheumatoid arthritis. Cochrane Database Syst Rev 4, CD002049. doi:10.1002/14651858.CD002049.pub2 PubMed

Heussler JK, Hinchey G, Margiotta E, Quinn R, Butler P, Martin J, Sturgess AD (1993) A double blind randomised trial of low power laser treatment in rheumatoid arthritis. Ann Rheum Dis 52(10):703–706PubMedCentralPubMedCrossRef

Bliddal H, Hellesen C, Ditlevsen P, Asselberghs J, Lyager L (1987) Soft-laser therapy of rheumatoid arthritis. Scand J Rheumatol 16(4):225–228PubMedCrossRef

Meireles SM, Jones A, Jennings F, Suda AL, Parizotto NA, Natour J (2010) Assessment of the effectiveness of low-level laser therapy on the hands of patients with rheumatoid arthritis: a randomized double-blind controlled trial. Clin Rheumatol 29(5):501–509. doi:10.1007/s10067-009-1347-0 PubMedCrossRef

Nakano J, Kataoka H, Sakamoto J, Origuchi T, Okita M, Yoshimura T (2009) Low-level laser irradiation promotes the recovery of atrophied gastrocnemius skeletal muscle in rats. Exp Physiol 94(9):1005–1015. doi:10.1113/expphysiol.2009.047738 PubMedCrossRef

10.

Ninomiya T, Hosoya A, Nakamura H, Sano K, Nishisaka T, Ozawa H (2007) Increase of bone volume by a nanosecond pulsed laser irradiation is caused by a decreased osteoclast number and an activated osteoblasts. Bone 40(1):140–148. doi:10.1016/j.bone.2006.07.026 PubMedCrossRef

11.

Kang H, Ko CY, Ryu Y, Seo DH, Kim HS, Jung B (2012) Development of a minimally invasive laser needle system: effects on cortical bone of osteoporotic mice. Lasers Med Sci 27(5):965–969. doi:10.1007/s10103-011-1014-y PubMedCrossRef

12.

Ko CY, Kang H, Ryu Y, Jung B, Kim H, Jeong D, Shin HI, Lim D, Kim HS (2013) The effects of minimally invasive laser needle system on suppression of trabecular bone loss induced by skeletal unloading. Lasers Med Sci. doi:10.1007/s10103-013-1265-x

13.

Ko CY, Kang H, Seo DH, Jung B, Schreiber J, Kim HS (2013) Low-level laser therapy using the minimally invasive laser needle system on osteoporotic bone in ovariectomized mice. Med Eng Phys 35(7):1015–1019. doi:10.1016/j.medengphy.2012.10.002 PubMedCrossRef

14.

Zhang L, Zhao J, Kuboyama N, Abiko Y (2011) Low-level laser irradiation treatment reduces CCL2 expression in rat rheumatoid synovia via a chemokine signaling pathway. Lasers Med Sci 26(5):707–717. doi:10.1007/s10103-011-0917-y PubMedCrossRef

15.

Parvathy SS, Masocha W (2013) Gait analysis of C57BL/6 mice with complete Freund’s adjuvant-induced arthritis using the CatWalk system. BMC Musculoskelet Disord 14:14. doi:10.1186/1471-2474-14-14 PubMedCentralPubMedCrossRef

16.

Kamala T (2007) Hock immunization: a humane alternative to mouse footpad injections. J Immunol Methods 328(1–2):204–214. doi:10.1016/j.jim.2007.08.004 PubMedCentralPubMedCrossRef

17.

Sommer AP, Pinheiro AL, Mester AR, Franke RP, Whelan HT (2001) Biostimulatory windows in low-intensity laser activation: lasers, scanners, and NASA’s light-emitting diode array system. J Clin Laser Med Surg 19(1):29–33. doi:10.1089/104454701750066910 PubMedCrossRef

18.

Yuan S, Devor A, Boas DA, Dunn AK (2005) Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging. Appl Optics 44(10):1823–1830CrossRef

19.

Ma Y, Pope RM (2005) The role of macrophages in rheumatoid arthritis. Curr Pharm Des 11(5):569–580PubMedCrossRef

20.

Pires-Oliveira DA, Oliveira RF, Amadei SU, Pacheco-Soares C, Rocha RF (2010) Laser 904 nm action on bone repair in rats with osteoporosis. Osteoporos Int 21(12):2109–2114. doi:10.1007/s00198-010-1183-8 PubMedCrossRef

21.

Berard A, Solomon DH, Avorn J (2000) Patterns of drug use in rheumatoid arthritis. J Rheumatol 27(7):1648–1655PubMed

Title: The effects of a minimally invasive laser needle system on complete Freund’s adjuvant-induced arthritis
Authors: Heesung Kang
Taeyoon Son
Aeju Lee
Inchan Youn
Dong Hyun Seo
Han Sung Kim
Byungjo Jung
Publication date: 01-09-2014
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 5/2014
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-014-1555-y

At a glance: The STEP trials

Springer Medicine

The effects of a minimally invasive laser needle system on complete Freund’s adjuvant-induced arthritis

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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