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01-09-2009 | Original Paper

The effect of Saccharomyces boulardii on reducing irinotecan-induced intestinal mucositis and diarrhea

Authors: Atakan Sezer, Ufuk Usta, Irfan Cicin

Published in: Medical Oncology | Issue 3/2009

Abstract

To investigate the efficiency of Saccharomyces boulardii on irinotecan-induced mucosal damage and diarrhea in rats, fifty rats were randomized into three groups with 20 rats in two study groups and 10 rats in the control group. Control group did not receive any treatment. Irinotecan (60 mg/kg) alone was administered intravenously once a day for four consecutive days to the rats of Group A. Throughout the experiment, Group B rats were additionally given Saccharomyces boulardii (800 mg/kg) for 3 days before administration of irinotecan and 7 days throughout the experiment. Delayed diarrhea was more severe in Group A than Group B (P = 0.009). The weight loss was 34.7 ± 3.8 mg for Group A, while it was 17.4 ± 1.7 mg for Group B (P < 0.001). Findings of mucositis most clearly appeared in the jejunum. Regarding edema (P = 0.003), leukocyte migration (P = 0.038), and inflammation (P = 0.006) significant recovery was detected in the mucosa of rats receiving Saccharomyces boulardii. Villous thickness was significantly greater in Group A than Group B (P < 0.001). The results indicate that Saccharomyces boulardii provided significant improvement in irinotecan-induced diarrhea and mucositis.

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Title: The effect of Saccharomyces boulardii on reducing irinotecan-induced intestinal mucositis and diarrhea
Authors: Atakan Sezer
Ufuk Usta
Irfan Cicin
Publication date: 01-09-2009
Publisher: Humana Press Inc
Published in: Medical Oncology / Issue 3/2009
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-008-9128-1

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