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01-04-2019 | Original Article

The effect of photobiomodulation on total amount of substance P in gingival crevicular fluid: placebo-controlled randomized clinical trial

Authors: Ezgi Doğanay Yıldız, Hakan Arslan, Serhat Köseoğlu, Taner Arabacı, Dursun Anıl Yıldız, Levent Savran

Published in: Lasers in Medical Science | Issue 3/2019

Abstract

To investigate the effect of photobiomodulation (PBM) and placebo on total amount of substance P in gingival crevicular fluid (GCF) pre- and postoperatively. Twenty-six patients having tooth with symptomatic apical periodontitis were enrolled in this study. GCF was collected preoperatively. The patients were assigned into two groups (n = 13), as follows: placebo and PBM. Sampling was repeated 7 days after root canal treatment. Two independent samples T test was used for analyzing of the differences between preoperative and postoperative substance P levels in GCF (p = .05). The Pearson correlation analysis was used for determination of correlation among substance P levels and other variables. For placebo group, there is no significant difference between preoperative and postoperative total amounts of substance P level (p = 0.553). For PBM group, postoperative total amount of substance P level was significantly higher than those of preoperative level (p = 0.005). Within the limitation of the present study, PBM has immunomodulation effect linked to the modulation of the total amount of substance P in the gingival crevicular fluid. Thai Clinical Trials Registry: TCTR20161228002

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Title: The effect of photobiomodulation on total amount of substance P in gingival crevicular fluid: placebo-controlled randomized clinical trial
Authors: Ezgi Doğanay Yıldız
Hakan Arslan
Serhat Köseoğlu
Taner Arabacı
Dursun Anıl Yıldız
Levent Savran
Publication date: 01-04-2019
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 3/2019
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-018-2625-3

At a glance: The STEP trials

Springer Medicine

The effect of photobiomodulation on total amount of substance P in gingival crevicular fluid: placebo-controlled randomized clinical trial

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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