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Open Access 01-10-2012 | Computed Tomography

The effect of iterative reconstruction on computed tomography assessment of emphysema, air trapping and airway dimensions

Authors: Onno M. Mets, Martin J. Willemink, Freek P. L. de Kort, Christian P. Mol, Tim Leiner, Matthijs Oudkerk, Mathias Prokop, Pim A. de Jong

Published in: European Radiology | Issue 10/2012

Abstract

Objectives

To determine the influence of iterative reconstruction (IR) on quantitative computed tomography (CT) measurements of emphysema, air trapping, and airway wall and lumen dimensions, compared to filtered back-projection (FBP).

Methods

Inspiratory and expiratory chest CTs of 75 patients (37 male, 38 female; mean age 64.0 ± 5.7 years) were reconstructed using FBP and IR. CT emphysema, CT air trapping and airway dimensions of a segmental bronchus were quantified using several commonly used quantification methods. The two algorithms were compared using the concordance correlation coefficient (p _c) and Wilcoxon signed rank test.

Results

Only the E/I-ratio_MLD as a measure of CT air trapping and airway dimensions showed no significant differences between the algorithms, whereas all CT emphysema and the other CT air trapping measures were significantly different at IR when compared to FBP (P < 0.001).

Conclusion

The evaluated IR algorithm significantly influences quantitative CT measures in the assessment of emphysema and air trapping. However, the E/I-ratio_MLD as a measure of CT air trapping, as well as the airway measurements, is unaffected by this reconstruction method. Quantitative CT of the lungs should be performed with careful attention to the CT protocol, especially when iterative reconstruction is introduced.

Key Points

• New techniques in CT allow numerous quantitative measurements of lung function.

• Iterative reconstruction influences quantitative CT measurements of emphysema and air trapping.

• Expiratory-to-inspiratory ratio of mean lung density and airway measurements are unaffected by iterative reconstruction.

• Quantitative lung-CT should be performed with careful attention to the CT protocol.

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Title: The effect of iterative reconstruction on computed tomography assessment of emphysema, air trapping and airway dimensions
Authors: Onno M. Mets
Martin J. Willemink
Freek P. L. de Kort
Christian P. Mol
Tim Leiner
Matthijs Oudkerk
Mathias Prokop
Pim A. de Jong
Publication date: 01-10-2012
Publisher: Springer-Verlag
Published in: European Radiology / Issue 10/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2489-z

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Springer Medicine

The effect of iterative reconstruction on computed tomography assessment of emphysema, air trapping and airway dimensions

Abstract

Objectives

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

Key Points

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