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European Radiology
Published in: European Radiology 1/2012

Open Access 01-01-2012 | Computed Tomography

The relationship between lung function impairment and quantitative computed tomography in chronic obstructive pulmonary disease

Authors: O. M. Mets, K. Murphy, P. Zanen, H. A. Gietema, J. W. Lammers, B. van Ginneken, M. Prokop, P. A. de Jong

Published in: European Radiology | Issue 1/2012

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Abstract

Objectives

To determine the relationship between lung function impairment and quantitative computed tomography (CT) measurements of air trapping and emphysema in a population of current and former heavy smokers with and without airflow limitation.

Methods

In 248 subjects (50 normal smokers; 50 mild obstruction; 50 moderate obstruction; 50 severe obstruction; 48 very severe obstruction) CT emphysema and CT air trapping were quantified on paired inspiratory and end-expiratory CT examinations using several available quantification methods. CT measurements were related to lung function (FEV1, FEV1/FVC, RV/TLC, Kco) by univariate and multivariate linear regression analysis.

Results

Quantitative CT measurements of emphysema and air trapping were strongly correlated to airflow limitation (univariate r-squared up to 0.72, p < 0.001). In multivariate analysis, the combination of CT emphysema and CT air trapping explained 68-83% of the variability in airflow limitation in subjects covering the total range of airflow limitation (p < 0.001).

Conclusions

The combination of quantitative CT air trapping and emphysema measurements is strongly associated with lung function impairment in current and former heavy smokers with a wide range of airflow limitation.

Key Points

• CT helps to automatically assess lung disease in heavy smokers
• CT quantitatively measures emphysema and small airways disease in heavy smokers
• CT air trapping and CT emphysema are associated with lung function impairment
Appendix
Available only for authorised users
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Metadata
Title
The relationship between lung function impairment and quantitative computed tomography in chronic obstructive pulmonary disease
Authors
O. M. Mets
K. Murphy
P. Zanen
H. A. Gietema
J. W. Lammers
B. van Ginneken
M. Prokop
P. A. de Jong
Publication date
01-01-2012
Publisher
Springer-Verlag
Published in
European Radiology / Issue 1/2012
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-011-2237-9

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