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Experimental Hematology & Oncology
Published in:

Open Access 01-12-2017 | Review

The development of bispecific antibodies and their applications in tumor immune escape

Authors: Xiaolong Zhang, Yuanyuan Yang, Dongmei Fan, Dongsheng Xiong

Published in: Experimental Hematology & Oncology | Issue 1/2017

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Abstract

During the past two decades, a great evolution of bispecific antibodies (BsAbs) for therapeutic applications has been made. BsAbs can bind simultaneously two different antigens or epitopes, which leads to a wide range of applications including redirecting T cells or NK cells to tumor cells, blocking two different signaling pathways, dual targeting of different disease mediators, and delivering payloads to targeted sites. Aside from approved catumaxomab (anti-CD3 and anti-EpCAM) and blinatumomab (anti-CD3 and anti-CD19), many more BsAbs are now in various phases of clinical development. Here, this review focus on the development of bispecific antibodies and their applications in tumor immune escape.
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Metadata
Title
The development of bispecific antibodies and their applications in tumor immune escape
Authors
Xiaolong Zhang
Yuanyuan Yang
Dongmei Fan
Dongsheng Xiong
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Experimental Hematology & Oncology / Issue 1/2017
Electronic ISSN: 2162-3619
DOI
https://doi.org/10.1186/s40164-017-0072-7

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