Published in:
01-08-2019 | ORIGINAL ARTICLE
The Deleterious Impact of Interleukin 9 to Hepatorenal Physiology
Authors:
Nadjania Saraiva de Lira Silva, Bruna Cristina Borges, Aline Alves da Silva, Patrícia de Castilhos, Thaíse Lara Teixeira, Samuel Cota Teixeira, Marlus Alves dos Santos, João Paulo Silva Servato, Allisson Benatti Justino, Douglas Carvalho Caixeta, Tatiana Carla Tomiosso, Foued Salmen Espindola, Claudio Vieira da Silva
Published in:
Inflammation
|
Issue 4/2019
Login to get access
Abstract
IL-9 is a pleiotropic cytokine, recently recognized as belonging to Th9 cells that are involved in various pathologies. We aimed to evaluate the role of IL-9 in the course of hepatic and renal fibrosis. Female C57BL/6 mice were treated subcutaneously with IL-9 10 ng/mouse and 20 ng/mouse for 40 days, alternating every 5 days each application, the negative control of which was treated with PBS and positive control with CCL4. IL-9 demonstrated fibrogenic activity, leading to increased collagen I and III deposition in both liver and kidney, as well as triggering lobular hepatitis. In addition, IL-9 induced an inflammatory response with recruitment of lymphocytes, neutrophils, and macrophages to both organs. The inflammation was present in the region of the portal and parenchymal zone in the liver and in the cortical and medullary zone in the kidney. IL-9 deregulated liver and kidney antioxidant activities. Our results showed that IL-9 was able to promote hepatorenal dysfunction. Moreover, IL-9 poses as a promising target for therapeutic interventions.