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Diabetologia
Published in: Diabetologia 1/2015

01-01-2015 | Commentary

The dark side of islet vasculature

Authors: Peter In’t Veld, Eckhard Lammert

Published in: Diabetologia | Issue 1/2015

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Excerpt

Pancreatic islets are highly vascularised and contain about five times more capillaries than exocrine pancreatic tissue [1, 2]. In addition, the islets receive 5–15% of the entire pancreatic blood supply, even though they represent only 1–2% of the pancreatic mass [3]. Moreover, as determined by beta cell- or pancreas-specific deletion of vascular endothelial growth factor-A (VEGF-A), the islet microvasculature is required for normal insulin release and physiological blood glucose levels [4, 5], indicating that a dense islet vasculature is needed for proper islet function. In addition, VEGF-A is necessary for proper islet revascularisation following islet transplantation [5, 6]. …
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Metadata
Title
The dark side of islet vasculature
Authors
Peter In’t Veld
Eckhard Lammert
Publication date
01-01-2015
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 1/2015
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-014-3418-2

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