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Published in: Trials 1/2013

Open Access 01-12-2013 | Research

The cost-effectiveness of a family meetings intervention to prevent depression and anxiety in family caregivers of patients with dementia: a randomized trial

Authors: Karlijn J Joling, Judith E Bosmans, Harm W J van Marwijk, Henriëtte E van der Horst, Philip Scheltens, Janet L MacNeil Vroomen, Hein P J van Hout

Published in: Trials | Issue 1/2013

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Abstract

Background

Dementia imposes a heavy burden on health and social care systems as well as on family caregivers who provide a substantial portion of the care. Interventions that effectively support caregivers may prevent or delay patient institutionalization and hence be cost-effective. However, evidence about the cost-effectiveness of such interventions is scarce. The aim of this study was to evaluate the cost-effectiveness of a family meetings intervention for family caregivers of dementia patients in comparison with usual care over a period of 12 months.

Methods

The economic evaluation was conducted from a societal perspective alongside a randomized trial of 192 primary caregivers with community-dwelling dementia patients. Outcome measures included the Quality Adjusted Life-Years (QALY) of caregivers and patients and the incidence of depression and anxiety disorders in caregivers. Missing cost and effect data were imputed using multiple imputations. Bootstrapping was used to estimate uncertainty around the cost-differences and the incremental cost-effectiveness ratio (ICER). The bootstrapped cost-effect pairs were plotted on a cost-effectiveness plane and used to estimate cost-effectiveness curves.

Results

No significant differences in costs and effects between the groups were found. At 12 months, total costs per patient and primary caregiver dyad were substantial: €77,832 for the intervention group and €75,201 for the usual care group (adjusted mean difference per dyad €4,149, 95% CI -13,371 to 21,956, ICER 157,534). The main cost driver was informal care (66% of total costs), followed by patients’ day treatment and costs of hospital and long-term care facility admissions (23%). Based on the cost-effectiveness acceptability curves, the maximum probability that the intervention was considered cost-effective in comparison with usual care reached 0.4 for the outcome QALY per patient-caregiver dyad and 0.6 for the caregivers’ incidence of depression and/or anxiety disorders regardless of the willingness to pay.

Conclusions

The annual costs of caring for a person with dementia were substantial with informal care being by far the largest contributor to the total societal costs. Based on this study, family meetings cannot be considered a cost-effective intervention strategy in comparison with usual care.

Trial registration

ISRCTN register, ISRCTN90163486
Appendix
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Literature
1.
go back to reference World Health Organization: Alzheimer’s Disease International. Dementia. A Public Health Priority. 2012, Geneva: WHO World Health Organization: Alzheimer’s Disease International. Dementia. A Public Health Priority. 2012, Geneva: WHO
2.
go back to reference Aneshensel CS, Pearlin LI, Mullan JT, Zarit SH, Whitlatch CJ: Profiles in Caregiving: The Unexpected Career. 1995, New York: Academic Press Aneshensel CS, Pearlin LI, Mullan JT, Zarit SH, Whitlatch CJ: Profiles in Caregiving: The Unexpected Career. 1995, New York: Academic Press
3.
go back to reference Cuijpers P: Depressive disorders in caregivers of dementia patients: a systematic review. Aging Ment Health. 2005, 9: 325-330. 10.1080/13607860500090078.CrossRefPubMed Cuijpers P: Depressive disorders in caregivers of dementia patients: a systematic review. Aging Ment Health. 2005, 9: 325-330. 10.1080/13607860500090078.CrossRefPubMed
4.
go back to reference Neundorfer MM, McClendon MJ, Smyth KA, Strauss ME, McCallum TJ: Does depression prior to caregiving increase vulnerability to depressive symptoms among caregivers of persons with Alzheimer’s disease?. Aging Ment Health. 2006, 10: 606-615. 10.1080/13607860600641036.CrossRefPubMed Neundorfer MM, McClendon MJ, Smyth KA, Strauss ME, McCallum TJ: Does depression prior to caregiving increase vulnerability to depressive symptoms among caregivers of persons with Alzheimer’s disease?. Aging Ment Health. 2006, 10: 606-615. 10.1080/13607860600641036.CrossRefPubMed
5.
go back to reference Schulz R, O’Brien AT, Bookwala J, Fleissner K: Psychiatric and physical morbidity effects of dementia caregiving: prevalence, correlates, and causes. Gerontologist. 1995, 35: 771-791. 10.1093/geront/35.6.771.CrossRefPubMed Schulz R, O’Brien AT, Bookwala J, Fleissner K: Psychiatric and physical morbidity effects of dementia caregiving: prevalence, correlates, and causes. Gerontologist. 1995, 35: 771-791. 10.1093/geront/35.6.771.CrossRefPubMed
6.
go back to reference Vitaliano PP, Zhang J, Scanlan JM: Is caregiving hazardous to one’s physical health? A meta-analysis. Psychol Bull. 2003, 129: 946-972.CrossRefPubMed Vitaliano PP, Zhang J, Scanlan JM: Is caregiving hazardous to one’s physical health? A meta-analysis. Psychol Bull. 2003, 129: 946-972.CrossRefPubMed
7.
go back to reference Whitlatch CJ, Feinberg LF, Sebesta DS: Depression and health in family caregivers: adaptation over time. J Aging Health. 1997, 9 (2): 222-243. 10.1177/089826439700900205.CrossRefPubMed Whitlatch CJ, Feinberg LF, Sebesta DS: Depression and health in family caregivers: adaptation over time. J Aging Health. 1997, 9 (2): 222-243. 10.1177/089826439700900205.CrossRefPubMed
8.
go back to reference Ory MG, Hoffman RR, Yee JL, Tennstedt S, Schulz R: Prevalence and impact of caregiving: a detailed comparison between dementia and nondementia caregivers. Gerontologist. 1999, 39: 177-185. 10.1093/geront/39.2.177.CrossRefPubMed Ory MG, Hoffman RR, Yee JL, Tennstedt S, Schulz R: Prevalence and impact of caregiving: a detailed comparison between dementia and nondementia caregivers. Gerontologist. 1999, 39: 177-185. 10.1093/geront/39.2.177.CrossRefPubMed
9.
go back to reference Alzheimer’s Disease International: World Alzheimer Report 2010. The Global Economic Impact of Dementia. 2010, London: Alzheimer’s Disease International Alzheimer’s Disease International: World Alzheimer Report 2010. The Global Economic Impact of Dementia. 2010, London: Alzheimer’s Disease International
10.
go back to reference Meerding WJ, Bonneux L, Polder JJ, Koopmanschap MA, van der Maas PJ: Demographic and epidemiological determinants of healthcare costs in Netherlands: cost of illness study. BMJ. 1998, 317: 111-115. 10.1136/bmj.317.7151.111.CrossRefPubMedPubMedCentral Meerding WJ, Bonneux L, Polder JJ, Koopmanschap MA, van der Maas PJ: Demographic and epidemiological determinants of healthcare costs in Netherlands: cost of illness study. BMJ. 1998, 317: 111-115. 10.1136/bmj.317.7151.111.CrossRefPubMedPubMedCentral
11.
go back to reference Wimo A, Jönsson B, Karlsson G, Winblad B: Health economics approaches to dementia. In The Health Economics of Dementia. 1998, Chichester: John Wiley Wimo A, Jönsson B, Karlsson G, Winblad B: Health economics approaches to dementia. In The Health Economics of Dementia. 1998, Chichester: John Wiley
12.
go back to reference Wimo A, Winblad B, Aguero-Torres H, von Strauss E: The magnitude of dementia occurrence in the world. Alzheimer Dis Assoc Disord. 2003, 17: 63-67. 10.1097/00002093-200304000-00002.CrossRefPubMed Wimo A, Winblad B, Aguero-Torres H, von Strauss E: The magnitude of dementia occurrence in the world. Alzheimer Dis Assoc Disord. 2003, 17: 63-67. 10.1097/00002093-200304000-00002.CrossRefPubMed
13.
go back to reference Thies W, Bleiler L, Alzheimer’s Association: Alzheimer’s disease facts and figures. Alzheimer’s Dement. 2011, 7: 208-244.CrossRef Thies W, Bleiler L, Alzheimer’s Association: Alzheimer’s disease facts and figures. Alzheimer’s Dement. 2011, 7: 208-244.CrossRef
14.
go back to reference Jonsson L, Eriksdotter JM, Kilander L, Soininen H, Hallikainen M, Waldemar G, Nygaard H, Andreasen N, Winblad B, Wimo A: Determinants of costs of care for patients with Alzheimer’s disease. Int J Geriatr Psychiatry. 2006, 21: 449-459. 10.1002/gps.1489.CrossRefPubMed Jonsson L, Eriksdotter JM, Kilander L, Soininen H, Hallikainen M, Waldemar G, Nygaard H, Andreasen N, Winblad B, Wimo A: Determinants of costs of care for patients with Alzheimer’s disease. Int J Geriatr Psychiatry. 2006, 21: 449-459. 10.1002/gps.1489.CrossRefPubMed
15.
go back to reference Luengo-Fernandez R, Leal J, Gray A: Dementia 2010. The Economic Burden of Dementia and Associated Research Finding in the United Kingdom. 2010, Cambridge: Alzheimer’s Research Trust Luengo-Fernandez R, Leal J, Gray A: Dementia 2010. The Economic Burden of Dementia and Associated Research Finding in the United Kingdom. 2010, Cambridge: Alzheimer’s Research Trust
16.
go back to reference Buchan J: The 'greying’ of the United Kingdom nursing workforce: implications for employment policy and practice. J Adv Nurs. 1999, 30: 818-826. 10.1046/j.1365-2648.1999.01159.x.CrossRefPubMed Buchan J: The 'greying’ of the United Kingdom nursing workforce: implications for employment policy and practice. J Adv Nurs. 1999, 30: 818-826. 10.1046/j.1365-2648.1999.01159.x.CrossRefPubMed
17.
go back to reference General Accounting Office: Nursing workforce: Emerging Nurse Shortage due to Multiple Factors. 2001, Washington, DC: GAO General Accounting Office: Nursing workforce: Emerging Nurse Shortage due to Multiple Factors. 2001, Washington, DC: GAO
18.
go back to reference Health Council of the Netherlands: Dementia. Publication no. 2002/04. 2002, The Hague: Health Council of the Netherlands Health Council of the Netherlands: Dementia. Publication no. 2002/04. 2002, The Hague: Health Council of the Netherlands
19.
go back to reference Institute of Medicine: Retooling for an Aging America: Building the Health Care Workforce. 2008, Washington DC: National Academies Press Institute of Medicine: Retooling for an Aging America: Building the Health Care Workforce. 2008, Washington DC: National Academies Press
20.
go back to reference Mittelman MS, Ferris SH, Shulman E, Steinberg G, Levin B: A family intervention to delay nursing home placement of patients with Alzheimer disease. A randomized controlled trial. JAMA. 1996, 276: 1725-1731. 10.1001/jama.1996.03540210033030.CrossRefPubMed Mittelman MS, Ferris SH, Shulman E, Steinberg G, Levin B: A family intervention to delay nursing home placement of patients with Alzheimer disease. A randomized controlled trial. JAMA. 1996, 276: 1725-1731. 10.1001/jama.1996.03540210033030.CrossRefPubMed
21.
go back to reference Mittelman MS, Haley WE, Clay OJ, Roth DL: Improving caregiver well-being delays nursing home placement of patients with Alzheimer disease. Neurology. 2006, 67: 1592-1599. 10.1212/01.wnl.0000242727.81172.91.CrossRefPubMed Mittelman MS, Haley WE, Clay OJ, Roth DL: Improving caregiver well-being delays nursing home placement of patients with Alzheimer disease. Neurology. 2006, 67: 1592-1599. 10.1212/01.wnl.0000242727.81172.91.CrossRefPubMed
22.
go back to reference Brodaty H, Green A, Koschera A: Meta-analysis of psychosocial interventions for caregivers of people with dementia. J Am Geriatr Soc. 2003, 51: 657-664. 10.1034/j.1600-0579.2003.00210.x.CrossRefPubMed Brodaty H, Green A, Koschera A: Meta-analysis of psychosocial interventions for caregivers of people with dementia. J Am Geriatr Soc. 2003, 51: 657-664. 10.1034/j.1600-0579.2003.00210.x.CrossRefPubMed
23.
go back to reference Olazaran J, Reisberg B, Clare L, Cruz I, Pena-Casanova J, Del Ser T, Woods B, Beck C, Auer S, Lai C, Spector A, Fazio S, Bond J, Kivipelto M, Brodaty H, Rojo JM, Collins H, Teri L, Mittelman M, Orrell M, Feldman HH, Muñiz R: Nonpharmacological therapies in Alzheimer’s disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010, 30: 161-178. 10.1159/000316119.CrossRefPubMed Olazaran J, Reisberg B, Clare L, Cruz I, Pena-Casanova J, Del Ser T, Woods B, Beck C, Auer S, Lai C, Spector A, Fazio S, Bond J, Kivipelto M, Brodaty H, Rojo JM, Collins H, Teri L, Mittelman M, Orrell M, Feldman HH, Muñiz R: Nonpharmacological therapies in Alzheimer’s disease: a systematic review of efficacy. Dement Geriatr Cogn Disord. 2010, 30: 161-178. 10.1159/000316119.CrossRefPubMed
24.
go back to reference Sorensen S, Pinquart M, Duberstein P: How effective are interventions with caregivers? An updated meta-analysis. Gerontologist. 2002, 42: 356-372. 10.1093/geront/42.3.356.CrossRefPubMed Sorensen S, Pinquart M, Duberstein P: How effective are interventions with caregivers? An updated meta-analysis. Gerontologist. 2002, 42: 356-372. 10.1093/geront/42.3.356.CrossRefPubMed
25.
go back to reference Jones C, Edwards RT, Hounsome B: A systematic review of the cost-effectiveness of interventions for supporting informal caregivers of people with dementia residing in the community. Int Psychogeriatr. 2012, 24: 6-18. 10.1017/S1041610211001207.CrossRefPubMed Jones C, Edwards RT, Hounsome B: A systematic review of the cost-effectiveness of interventions for supporting informal caregivers of people with dementia residing in the community. Int Psychogeriatr. 2012, 24: 6-18. 10.1017/S1041610211001207.CrossRefPubMed
26.
go back to reference Knapp M, Iemmi V, Romeo R: Dementia care costs and outcomes: a systematic review. Int J Geriatr Psychiatry. 2013, 28 (6): 551-561. 10.1002/gps.3864.CrossRefPubMed Knapp M, Iemmi V, Romeo R: Dementia care costs and outcomes: a systematic review. Int J Geriatr Psychiatry. 2013, 28 (6): 551-561. 10.1002/gps.3864.CrossRefPubMed
27.
go back to reference Graff MJ, Adang EM, Vernooij-Dassen MJ, Dekker J, Jonsson L, Thijssen M, Hoefnagels WH, Rikkert MG: Community occupational therapy for older patients with dementia and their care givers: cost effectiveness study. BMJ. 2008, 336: 134-138. 10.1136/bmj.39408.481898.BE.CrossRefPubMedPubMedCentral Graff MJ, Adang EM, Vernooij-Dassen MJ, Dekker J, Jonsson L, Thijssen M, Hoefnagels WH, Rikkert MG: Community occupational therapy for older patients with dementia and their care givers: cost effectiveness study. BMJ. 2008, 336: 134-138. 10.1136/bmj.39408.481898.BE.CrossRefPubMedPubMedCentral
28.
go back to reference Mittelman MS, Ferris SH, Shulman E, Steinberg G, Ambinder A, Mackell JA, Cohen J: A comprehensive support program: effect on depression in spouse-caregivers of AD patients. Gerontologist. 1995, 35: 792-802. 10.1093/geront/35.6.792.CrossRefPubMed Mittelman MS, Ferris SH, Shulman E, Steinberg G, Ambinder A, Mackell JA, Cohen J: A comprehensive support program: effect on depression in spouse-caregivers of AD patients. Gerontologist. 1995, 35: 792-802. 10.1093/geront/35.6.792.CrossRefPubMed
29.
go back to reference Mittelman MS, Roth DL, Coon DW, Haley WE: Sustained benefit of supportive intervention for depressive symptoms in caregivers of patients with Alzheimer’s disease. Am J Psychiatry. 2004, 161: 850-856. 10.1176/appi.ajp.161.5.850.CrossRefPubMed Mittelman MS, Roth DL, Coon DW, Haley WE: Sustained benefit of supportive intervention for depressive symptoms in caregivers of patients with Alzheimer’s disease. Am J Psychiatry. 2004, 161: 850-856. 10.1176/appi.ajp.161.5.850.CrossRefPubMed
30.
go back to reference Mittelman MS, Ferris SH, Steinberg G, Shulman E, Mackell JA, Ambinder A, Cohen J: An intervention that delays institutionalization of Alzheimer’s disease patients: treatment of spouse-caregivers. Gerontologist. 1993, 33: 730-740. 10.1093/geront/33.6.730.CrossRefPubMed Mittelman MS, Ferris SH, Steinberg G, Shulman E, Mackell JA, Ambinder A, Cohen J: An intervention that delays institutionalization of Alzheimer’s disease patients: treatment of spouse-caregivers. Gerontologist. 1993, 33: 730-740. 10.1093/geront/33.6.730.CrossRefPubMed
31.
go back to reference Joling KJ, Van Hout HP, Scheltens P, Vernooij-Dassen M, van den Berg B, Bosmans J, Gillissen F, Mittelman M, van Marwijk HW: (Cost)-effectiveness of family meetings on indicated prevention of anxiety and depressive symptoms and disorders of primary family caregivers of patients with dementia: design of a randomized controlled trial. BMC Geriatr. 2008, 8: 2-10.1186/1471-2318-8-2.CrossRefPubMedPubMedCentral Joling KJ, Van Hout HP, Scheltens P, Vernooij-Dassen M, van den Berg B, Bosmans J, Gillissen F, Mittelman M, van Marwijk HW: (Cost)-effectiveness of family meetings on indicated prevention of anxiety and depressive symptoms and disorders of primary family caregivers of patients with dementia: design of a randomized controlled trial. BMC Geriatr. 2008, 8: 2-10.1186/1471-2318-8-2.CrossRefPubMedPubMedCentral
32.
go back to reference Joling KJ, van Marwijk HW, Smit F, van der Horst HE, Scheltens P, van de Ven P, Mittelman MS, van Hout HPJ: Does a family meetings intervention prevent depression and anxiety in family caregivers of dementia patients?. A randomized trial. PLoS One. 2012, 7: e30936-10.1371/journal.pone.0030936.CrossRefPubMed Joling KJ, van Marwijk HW, Smit F, van der Horst HE, Scheltens P, van de Ven P, Mittelman MS, van Hout HPJ: Does a family meetings intervention prevent depression and anxiety in family caregivers of dementia patients?. A randomized trial. PLoS One. 2012, 7: e30936-10.1371/journal.pone.0030936.CrossRefPubMed
33.
go back to reference Joling KJ, van Marwijk HW, van der Horst HE, Scheltens P, van de Ven PM, Appels BA, van Hout HPJ: Effectiveness of family meetings for family caregivers on delaying time to nursing home placement of dementia patients: a randomized trial. PLoS One. 2012, 7: e42145-10.1371/journal.pone.0042145.CrossRefPubMedPubMedCentral Joling KJ, van Marwijk HW, van der Horst HE, Scheltens P, van de Ven PM, Appels BA, van Hout HPJ: Effectiveness of family meetings for family caregivers on delaying time to nursing home placement of dementia patients: a randomized trial. PLoS One. 2012, 7: e42145-10.1371/journal.pone.0042145.CrossRefPubMedPubMedCentral
34.
go back to reference Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998, 59 (Suppl 20): 22-33.PubMed Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998, 59 (Suppl 20): 22-33.PubMed
35.
go back to reference Ware JE, Kosinski M, Keller S: A 12-item short form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996, 34: 220-233. 10.1097/00005650-199603000-00003.CrossRefPubMed Ware JE, Kosinski M, Keller S: A 12-item short form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996, 34: 220-233. 10.1097/00005650-199603000-00003.CrossRefPubMed
36.
go back to reference Brazier JE, Roberts J: The estimation of a preference-based measure of health from the SF-12. Med Care. 2004, 42: 851-859. 10.1097/01.mlr.0000135827.18610.0d.CrossRefPubMed Brazier JE, Roberts J: The estimation of a preference-based measure of health from the SF-12. Med Care. 2004, 42: 851-859. 10.1097/01.mlr.0000135827.18610.0d.CrossRefPubMed
37.
go back to reference Hakkaart-van Roijen L, Tan SS, Bouwmans CAM: Handleiding voor kostenonderzoek: Methoden en standaard kostprijzen voor economische evaluaties in de gezondheidszorg. Geactualiseerde versie 2010. [Dutch manual for costing in economic evaluations]. 2011, Diemen: College voor zorgverzekeringen (CVZ) Hakkaart-van Roijen L, Tan SS, Bouwmans CAM: Handleiding voor kostenonderzoek: Methoden en standaard kostprijzen voor economische evaluaties in de gezondheidszorg. Geactualiseerde versie 2010. [Dutch manual for costing in economic evaluations]. 2011, Diemen: College voor zorgverzekeringen (CVZ)
38.
go back to reference Z-index: Z-index: G-Standaard. 2006, The Netherlands: The Hague, College voor Zorgverzekeringen (CVZ) Z-index: Z-index: G-Standaard. 2006, The Netherlands: The Hague, College voor Zorgverzekeringen (CVZ)
39.
go back to reference Koopmanschap MA, Rutten FF, van Ineveld BM, van Roijen L: The friction cost method for measuring indirect costs of disease. J Health Econ. 1995, 14: 171-189. 10.1016/0167-6296(94)00044-5.CrossRefPubMed Koopmanschap MA, Rutten FF, van Ineveld BM, van Roijen L: The friction cost method for measuring indirect costs of disease. J Health Econ. 1995, 14: 171-189. 10.1016/0167-6296(94)00044-5.CrossRefPubMed
40.
go back to reference Oostenbrink JB, Bouwmans CAM, Koopmanschap MA, Rutten FF: Handleiding voor kostenonderzoek: Methoden en standaard kostprijzen voor economische evaluaties in de gezondheidszorg, Geactualiseerde versie 2004 edn. College voor. 2004, Diemen: Zorgverzekeringen Oostenbrink JB, Bouwmans CAM, Koopmanschap MA, Rutten FF: Handleiding voor kostenonderzoek: Methoden en standaard kostprijzen voor economische evaluaties in de gezondheidszorg, Geactualiseerde versie 2004 edn. College voor. 2004, Diemen: Zorgverzekeringen
41.
go back to reference Rubin DB: Multiple Imputation for Nonresponse in Surveys. 1987, New York: John Wiley & SonsCrossRef Rubin DB: Multiple Imputation for Nonresponse in Surveys. 1987, New York: John Wiley & SonsCrossRef
42.
go back to reference Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67: 361-370. 10.1111/j.1600-0447.1983.tb09716.x.CrossRefPubMed Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67: 361-370. 10.1111/j.1600-0447.1983.tb09716.x.CrossRefPubMed
43.
go back to reference Burton A, Billingham LJ, Bryan S: Cost-effectiveness in clinical trials: using multiple imputation to deal with incomplete cost data. Clin Trials. 2007, 4: 154-161. 10.1177/1740774507076914.CrossRefPubMed Burton A, Billingham LJ, Bryan S: Cost-effectiveness in clinical trials: using multiple imputation to deal with incomplete cost data. Clin Trials. 2007, 4: 154-161. 10.1177/1740774507076914.CrossRefPubMed
44.
go back to reference Efron B: Missing data, imputation and the bootstrap. J Am Stat Assoc. 1994, 89: 463-475. 10.1080/01621459.1994.10476768.CrossRef Efron B: Missing data, imputation and the bootstrap. J Am Stat Assoc. 1994, 89: 463-475. 10.1080/01621459.1994.10476768.CrossRef
45.
go back to reference Fenwick E, O’Brien BJ, Briggs A: Cost-effectiveness acceptability curves–facts, fallacies and frequently asked questions. Health Econ. 2004, 13: 405-415. 10.1002/hec.903.CrossRefPubMed Fenwick E, O’Brien BJ, Briggs A: Cost-effectiveness acceptability curves–facts, fallacies and frequently asked questions. Health Econ. 2004, 13: 405-415. 10.1002/hec.903.CrossRefPubMed
46.
go back to reference Wimo A, Winblad B, Jonsson L: An estimate of the total worldwide societal costs of dementia in 2005. Alzheimers Dement. 2007, 3: 81-91. 10.1016/j.jalz.2007.02.001.CrossRefPubMed Wimo A, Winblad B, Jonsson L: An estimate of the total worldwide societal costs of dementia in 2005. Alzheimers Dement. 2007, 3: 81-91. 10.1016/j.jalz.2007.02.001.CrossRefPubMed
48.
go back to reference Wilson E, Thalanany M, Shepstone L, Charlesworth G, Poland F, Harvey I, Price D, Reynolds S, Mugford M: Befriending carers of people with dementia: a cost utility analysis. Int J Geriatr Psychiatry. 2009, 24: 610-623. 10.1002/gps.2164.CrossRefPubMed Wilson E, Thalanany M, Shepstone L, Charlesworth G, Poland F, Harvey I, Price D, Reynolds S, Mugford M: Befriending carers of people with dementia: a cost utility analysis. Int J Geriatr Psychiatry. 2009, 24: 610-623. 10.1002/gps.2164.CrossRefPubMed
49.
go back to reference Roberts J, Browne G, Milne C, Spooner L, Gafni A, Drummond-Young M, LeGris J, Watt S, LeClair K, Beaumont L, Roberts J: Problem-solving counseling for caregivers of the cognitively impaired: effective for whom?. Nurs Res. 1999, 48: 162-172. 10.1097/00006199-199905000-00006.CrossRefPubMed Roberts J, Browne G, Milne C, Spooner L, Gafni A, Drummond-Young M, LeGris J, Watt S, LeClair K, Beaumont L, Roberts J: Problem-solving counseling for caregivers of the cognitively impaired: effective for whom?. Nurs Res. 1999, 48: 162-172. 10.1097/00006199-199905000-00006.CrossRefPubMed
50.
go back to reference Pinquart M, Sorensen S: Gender differences in self-concept and psychological well-being in old age: a meta-analysis. J Gerontol B Psychol Sci Soc Sci. 2001, 56: 195-213.CrossRef Pinquart M, Sorensen S: Gender differences in self-concept and psychological well-being in old age: a meta-analysis. J Gerontol B Psychol Sci Soc Sci. 2001, 56: 195-213.CrossRef
51.
go back to reference Schulz R, Williamson GM: A 2-year longitudinal study of depression among Alzheimer’s caregivers. Psychol Aging. 1991, 6: 569-578.CrossRefPubMed Schulz R, Williamson GM: A 2-year longitudinal study of depression among Alzheimer’s caregivers. Psychol Aging. 1991, 6: 569-578.CrossRefPubMed
52.
go back to reference Luijendijk HJ, van den Berg JF, Dekker MJ, van Tuijl HR, Otte W, Smit F, Hofman A, Stricker BH, Tiemeier H: Incidence and recurrence of late-life depression. Arch Gen Psychiatry. 2008, 65: 1394-1401. 10.1001/archpsyc.65.12.1394.CrossRefPubMed Luijendijk HJ, van den Berg JF, Dekker MJ, van Tuijl HR, Otte W, Smit F, Hofman A, Stricker BH, Tiemeier H: Incidence and recurrence of late-life depression. Arch Gen Psychiatry. 2008, 65: 1394-1401. 10.1001/archpsyc.65.12.1394.CrossRefPubMed
53.
go back to reference Norton MC, Skoog I, Toone L, Corcoran C, Tschanz JT, Lisota RD, Hart AD, Zandi PP, Breitner JC, Welsh-Bohmer KA, Steffens DC, Cache County Investigators: Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County study. Am J Geriatr Psychiatry. 2006, 14: 237-245. 10.1097/01.JGP.0000196626.34881.42.CrossRefPubMed Norton MC, Skoog I, Toone L, Corcoran C, Tschanz JT, Lisota RD, Hart AD, Zandi PP, Breitner JC, Welsh-Bohmer KA, Steffens DC, Cache County Investigators: Three-year incidence of first-onset depressive syndrome in a population sample of older adults: the Cache County study. Am J Geriatr Psychiatry. 2006, 14: 237-245. 10.1097/01.JGP.0000196626.34881.42.CrossRefPubMed
54.
go back to reference Palsson SP, Ostling S, Skoog I: The incidence of first-onset depression in a population followed from the age of 70 to 85. Psychol Med. 2001, 31: 1159-1168.PubMed Palsson SP, Ostling S, Skoog I: The incidence of first-onset depression in a population followed from the age of 70 to 85. Psychol Med. 2001, 31: 1159-1168.PubMed
55.
go back to reference Alzheimer’s Association: Alzheimer’s Disease. Facts and Figures. Alzheimer’s & Dementia, volume 6. 2010, Alzheimer’s Association: Washington, DC Alzheimer’s Association: Alzheimer’s Disease. Facts and Figures. Alzheimer’s & Dementia, volume 6. 2010, Alzheimer’s Association: Washington, DC
56.
go back to reference Oostenbrink JB, Al MJ: The analysis of incomplete cost data due to dropout. Health Econ. 2005, 14: 763-776. 10.1002/hec.966.CrossRefPubMed Oostenbrink JB, Al MJ: The analysis of incomplete cost data due to dropout. Health Econ. 2005, 14: 763-776. 10.1002/hec.966.CrossRefPubMed
57.
go back to reference Briggs A, Clark T, Wolstenholme J, Clarke P: Missing… presumed at random: cost-analysis of incomplete data. Health Econ. 2003, 12: 377-392. 10.1002/hec.766.CrossRefPubMed Briggs A, Clark T, Wolstenholme J, Clarke P: Missing… presumed at random: cost-analysis of incomplete data. Health Econ. 2003, 12: 377-392. 10.1002/hec.766.CrossRefPubMed
Metadata
Title
The cost-effectiveness of a family meetings intervention to prevent depression and anxiety in family caregivers of patients with dementia: a randomized trial
Authors
Karlijn J Joling
Judith E Bosmans
Harm W J van Marwijk
Henriëtte E van der Horst
Philip Scheltens
Janet L MacNeil Vroomen
Hein P J van Hout
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Trials / Issue 1/2013
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-14-305

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