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Breast Cancer Research
Published in: Breast Cancer Research 3/2010

01-06-2010 | Review

The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis

Authors: Jessica McCready, Lisa M Arendt, Jenny A Rudnick, Charlotte Kuperwasser

Published in: Breast Cancer Research | Issue 3/2010

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Abstract

Breast cancer is a heterogeneous disease whose prognosis varies depending upon the developmental stage of the breast tissue at diagnosis. Notably, breast cancers associated with pregnancy exhibit increased rates of metastasis and poorer long-term survival compared to those diagnosed after menopause. However, postmenopausal breast cancers associated with obesity exhibit a more aggressive behavior and confer decreased overall patient survival compared to those diagnosed in non-obese individuals. Since the mammary gland is a dynamic tissue that undergoes significant changes throughout a woman's lifetime, especially during pregnancy and following menopause, we present evidence to support the notion that changes occurring throughout development within the mammary stromal compartment may account for some of the biological differences in breast cancer subtypes and behaviors.
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Metadata
Title
The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis
Authors
Jessica McCready
Lisa M Arendt
Jenny A Rudnick
Charlotte Kuperwasser
Publication date
01-06-2010
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 3/2010
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2578

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