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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2010

Open Access 01-12-2010 | Research

The clinical behavior of mixed ductal/lobular carcinoma of the breast: a clinicopathologic analysis

Authors: Aparna Suryadevara, Lakshmi P Paruchuri, Nassim Banisaeed, Gary Dunnington, Krishna A Rao

Published in: World Journal of Surgical Oncology | Issue 1/2010

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Abstract

Background

To date, the clinical presentation and prognosis of mixed ductal/lobular mammary carcinomas has not been well studied, and little is known about the outcome of this entity. Thus, best management practices remain undetermined due to a dearth of knowledge on this topic.

Methods

In this paper, we present a clinicopathologic analysis of patients at our institution with this entity and compare them to age-matched controls with purely invasive ductal carcinoma (IDC) and historical data from patients with purely lobular carcinoma and also stain-available tumor specimens for E-cadherin. We have obtained 100 cases of ductal and 50 cases of mixed ductal/lobular breast carcinoma.

Results

Clinically, the behavior of mixed ductal/lobular tumors seemed to demonstrate some important differences from their ductal counterparts, particularly a lower rate of metastatic spread but with a much higher rate of second primary breast cancers.

Conclusions

Our data suggests that mixed ductal/lobular carcinomas are a distinct clinicopathologic entity incorporating some features of both lobular and ductal carcinomas and representing a pleomorphic variant of IDC.
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Metadata
Title
The clinical behavior of mixed ductal/lobular carcinoma of the breast: a clinicopathologic analysis
Authors
Aparna Suryadevara
Lakshmi P Paruchuri
Nassim Banisaeed
Gary Dunnington
Krishna A Rao
Publication date
01-12-2010
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2010
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-8-51

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