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Endocrine
Published in: Endocrine 1/2017

01-10-2017 | Original Article

The cellular selection between apoptosis and autophagy: roles of vitamin D, glucose and immune response in diabetic nephropathy

Authors: Magda Hamzawy, Sarah Ali Abdelhameed Gouda, Laila Rashid, Mary Attia Morcos, Heba Shoukry, Nivin Sharawy

Published in: Endocrine | Issue 1/2017

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Abstract

Background and aims

Apoptosis, autophagy and cell cycle arrest are cellular responses to injury which are supposed to play fundamental roles in initiation and progression of diabetic nephropathy (DN). The aims of the present study is to shed light on the potential effects of vitamin D analog 22-oxacalcitriol (OCT) on different cell responses during DN, and the possible interplay between both glucose, immune system and vitamin D in determining the cell fate.

Method

All rats were randomly allocated into one of three groups: control, vehicle-treated DN group and OCT-treated DN group. Eight weeks after induction of diabetes, the rats were killed. Fasting blood glucose levels, serum 25 (OH) D, renal functions, cytokines and gene expression of autophagy, apoptotic and cell cycle arrest markers were assessed. In addition, the histological assessment of renal architecture was done.

Results

OCT treatment remarkably improved the renal functions and albuminuria. The reductions in mesangial cell hypertrophy, extracellular matrix as well as cell loss were significantly associated with upregulation of pro-autophagy gene expressions and downregulation of both pro-apoptotic and G1-cell cycle arrest genes expression. The reno-protective effects of OCT treatment were associated with significant attenuation of the fasting blood glucose, serum IL-6, renal TLR-4 and IFN-g gene expression.

Conclusion

Modulator effects of OCT on glucose and immune system play important roles in renal cell fate decision and chronic kidney disease progression.
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Metadata
Title
The cellular selection between apoptosis and autophagy: roles of vitamin D, glucose and immune response in diabetic nephropathy
Authors
Magda Hamzawy
Sarah Ali Abdelhameed Gouda
Laila Rashid
Mary Attia Morcos
Heba Shoukry
Nivin Sharawy
Publication date
01-10-2017
Publisher
Springer US
Published in
Endocrine / Issue 1/2017
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-017-1402-6

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