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Published in: Journal of Cancer Research and Clinical Oncology 11/2014

01-11-2014 | Original Article – Cancer Research

The BRAF mutation is associated with the prognosis in colorectal cancer

Authors: Tae Sung Ahn, Dongjun Jeong, Myoung Won Son, Haeil Jung, Soyoung Park, Hyungjoo Kim, Sang Byung Bae, Han Jo Kim, Young-Woo Jeon, Moon Soo Lee, Moo-Jun Baek

Published in: Journal of Cancer Research and Clinical Oncology | Issue 11/2014

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Abstract

Background

Two members of the Ras/Raf signaling pathway, KRAS and B-raf, are suspected to be involved in the stepwise progression of colorectal cancer (CRC) tumorigenesis.

Objective

We compared the KRAS and BRAF mutation status of CRC patients with their clinicopathological characteristics and examined the effect of mutation status on survival rates.

Methods

DNA was extracted from 164 samples, and the mutation statuses of KRAS and BRAF were assessed using peptide PNA clamp real-time PCR method. The presences of mutation were compared with clinicopathological factors and 5-year survival rate.

Results

Among the 164 CRC cases, KRAS mutation as detected in 71 cases (43.3 %), respectively, with no relationship with clinicopathological factors of the patients. On Kaplan–Meier survival analysis, KRAS mutation was not significantly associated with survival (p = 0.971). BRAF mutation was detected in 26 cases (15.9 %) and not associated with clinicopathological factors of the patients. However, the 5-year survival rate of BRAF mutations was significantly decreased (p = 0.02).

Conclusions

The presence of KRAS mutation did not correlate with the various clinicopathological factors of CRC patients or the survival rate. However, the survival rate was reduced in BRAF-mutated CRC patients. Therefore, BRAF mutation could be an important prognostic factor in CRC patients.
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Metadata
Title
The BRAF mutation is associated with the prognosis in colorectal cancer
Authors
Tae Sung Ahn
Dongjun Jeong
Myoung Won Son
Haeil Jung
Soyoung Park
Hyungjoo Kim
Sang Byung Bae
Han Jo Kim
Young-Woo Jeon
Moon Soo Lee
Moo-Jun Baek
Publication date
01-11-2014
Publisher
Springer Berlin Heidelberg
Published in
Journal of Cancer Research and Clinical Oncology / Issue 11/2014
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-014-1735-y

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