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Open Access 01-10-2014 | Review Article

The association of PTPN22 rs2476601 polymorphism and CTLA-4 rs231775 polymorphism with LADA risks: a systematic review and meta-analysis

Authors: Fang Dong, Guang Yang, Hong-Wei Pan, Wei-Huang Huang, Li-Peng Jing, Wen-Kai Liang, Na Zhang, Bao-Huan Zhang, Man Wang, Yang Liu, Li-Ju Zhang, Si-Heng Zhang, He Li, Chuan Chen, Li-Hong Nie, Chun-Xia Jing

Published in: Acta Diabetologica | Issue 5/2014

Abstract

Although the polymorphisms of PTPN22 and the variants of CTLA-4 have been reported to be the susceptibility genes, which increased risk of latent autoimmune diabetes in adults (LADA), the results remained inconclusive. The aim of this meta-analysis was to evaluate the association between the polymorphisms of two genes and LADA. We performed a systematic review by identifying relevant studies and applied meta-analysis to pool gene effects. Data from ten studies published between 2001 and 2013 were pooled for two polymorphisms: rs2476601 in the PTPN22 gene and rs231775 in the CTLA-4 gene. Data extraction and assessments for risk of bias were independently performed by two reviewers. Fixed-effect model and random-effect model were used to pool the odds ratios; meanwhile, heterogeneity test, publication bias and sensitive analysis were explored. The minor T allele at rs2476601 and the minor G at rs231775 carried estimated relative risks (odds ratio) of 1.52 (95 % CI 1.29–1.79) and 1.39 (95 % CI 1.11–1.74), respectively. These alleles contributed to an absolute lowering of the risk of all LADA by 4.88 and 14.93 % when individuals do not carry these alleles. The estimated lambdas were 0.49 and 0.63, suggesting a codominant model of effects was most likely for two genes. In summary, our systematic review has demonstrated that PTPN22 rs2476601 and CTLA-4 rs231775 are potential risk factors for LADA. An updated meta-analysis is required when more studies are published to increase the power of these polymorphisms and LADA.

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Tuomi T, Groop LC, Zimmet PZ, Rowley MJ, Knowles W, Mackay IR (1993) Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 42(2):359–362PubMedCrossRef

Gale EA (2005) Latent autoimmune diabetes in adults: a guide for the perplexed. Diabetologia 48(11):2195–2199. doi:10.1007/s00125-005-1954-5 PubMedCrossRef

Rolandsson O, Palmer JP (2010) Latent autoimmune diabetes in adults (LADA) is dead: long live autoimmune diabetes! Diabetologia 53(7):1250–1253. doi:10.1007/s00125-010-1713-0 PubMedCrossRef

Zimmet PZ (1995) The pathogenesis and prevention of diabetes in adults. Genes, autoimmunity, and demography. Diabetes Care 18(7):1050–1064PubMed

Schernthaner G, Hink S, Kopp HP, Muzyka B, Streit G, Kroiss A (2001) Progress in the characterization of slowly progressive autoimmune diabetes in adult patients (LADA or type 1.5 diabetes). Exp Clin Endocrinol Diabetes 109(Suppl 2):S94–S108. doi:10.1055/s-2001-18573

Stenstrom G, Gottsater A, Bakhtadze E, Berger B, Sundkvist G (2005) Latent autoimmune diabetes in adults: definition, prevalence, beta-cell function, and treatment. Diabetes 54(Suppl 2):S68–S72PubMedCrossRef

Ekholm E, Gottsater A, Dahlin LB, Sundkvist G (2012) No signs of progressive beta cell damage during 20 years of prospective follow-up of autoantibody-negative diabetes. Acta Diabetol 49(1):57–62. doi:10.1007/s00592-011-0273-1 PubMedCrossRef

Turner R, Stratton I, Horton V, Manley S, Zimmet P, Mackay IR, Shattock M, Bottazzo GF, Holman R (1997) UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes UK Prospective Diabetes Study Group. Lancet 350(9087):1288–1293PubMedCrossRef

Cervin C, Lyssenko V, Bakhtadze E, Lindholm E, Nilsson P, Tuomi T, Cilio CM, Groop L (2008) Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes. Diabetes 57(5):1433–1437. doi:10.2337/db07-0299 PubMedCrossRef

10.

Cohen S, Dadi H, Shaoul E, Sharfe N, Roifman CM (1999) Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase Lyp. Blood 93(6):2013–2024PubMed

11.

Wang S, Dong H, Han J, Ho WT, Fu X, Zhao ZJ (2010) Identification of a variant form of tyrosine phosphatase LYP. BMC Mol Biol 11:78. doi:10.1186/1471-2199-11-78 PubMedCrossRefPubMedCentral

12.

Cloutier JF, Veillette A (1999) Cooperative inhibition of T-cell antigen receptor signaling by a complex between a kinase and a phosphatase. J Exp Med 189(1):111–121PubMedCrossRefPubMedCentral

13.

Cannons JL, Schwartzberg PL (2004) Fine-tuning lymphocyte regulation: what’s new with tyrosine kinases and phosphatases? Curr Opin Immunol 16(3):296–303. doi:10.1016/j.coi.2004.03.011 PubMedCrossRef

14.

Dultz G, Matheis N, Dittmar M, Rohrig B, Bender K, Kahaly GJ (2009) The protein tyrosine phosphatase non-receptor type 22 C1858T polymorphism is a joint susceptibility locus for immunthyroiditis and autoimmune diabetes. Thyroid Off J Am Thyroid Assoc 19(2):143–148. doi:10.1089/thy.2008.0301 CrossRef

15.

Dieude P, Teixeira VH, Pierlot C, Cornelis F, Petit-Teixeira E (2008) Testing for linkage and association with rheumatoid arthritis a ptpn22 promoter polymorphism reported to be associated and linked with type 1 diabetes in the Caucasian population. Ann Rheum Dis 67(6):900–901. doi:10.1136/ard.2007.077180 PubMedCrossRef

16.

Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, Ardlie KG, Huang Q, Smith AM, Spoerke JM, Conn MT, Chang M, Chang SY, Saiki RK, Catanese JJ, Leong DU, Garcia VE, McAllister LB, Jeffery DA, Lee AT, Batliwalla F, Remmers E, Criswell LA, Seldin MF, Kastner DL, Amos CI, Sninsky JJ, Gregersen PK (2004) A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 75(2):330–337. doi:10.1086/422827 PubMedCrossRefPubMedCentral

17.

Ueda H, Howson JM, Esposito L, Heward J, Snook H, Chamberlain G, Rainbow DB, Hunter KM, Smith AN, Di Genova G, Herr MH, Dahlman I, Payne F, Smyth D, Lowe C, Twells RC, Howlett S, Healy B, Nutland S, Rance HE, Everett V, Smink LJ, Lam AC, Cordell HJ, Walker NM, Bordin C, Hulme J, Motzo C, Cucca F, Hess JF, Metzker ML, Rogers J, Gregory S, Allahabadia A, Nithiyananthan R, Tuomilehto-Wolf E, Tuomilehto J, Bingley P, Gillespie KM, Undlien DE, Ronningen KS, Guja C, Ionescu-Tirgoviste C, Savage DA, Maxwell AP, Carson DJ, Patterson CC, Franklyn JA, Clayton DG, Peterson LB, Wicker LS, Todd JA, Gough SC (2003) Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423(6939):506–511. doi:10.1038/nature01621 PubMedCrossRef

18.

Greene JL, Leytze GM, Emswiler J, Peach R, Bajorath J, Cosand W, Linsley PS (1996) Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions. J Biol Chem 271(43):26762–26771PubMedCrossRef

19.

Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW (1995) Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (New York, NY) 270(5238):985–988CrossRef

20.

Kisand K, Uibo R (2012) LADA and T1D in Estonian population—two different genetic risk profiles. Gene 497(2):285–291. doi:10.1016/j.gene.2012.01.089 PubMedCrossRef

21.

Petrone A, Suraci C, Capizzi M, Giaccari A, Bosi E, Tiberti C, Cossu E, Pozzilli P, Falorni A, Buzzetti R (2008) The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3. Diabetes Care 31(3):534–538. doi:10.2337/dc07-1457 PubMedCrossRef

22.

Pettersen E, Skorpen F, Kvaloy K, Midthjell K, Grill V (2010) Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trondelag Health Study. Diabetes 59(1):302–310. doi:10.2337/db09-0923 PubMedCrossRefPubMedCentral

23.

Jin P, Huang G, Lin J, Yang L, Xiang B, Zhou W, Zhou Z (2011) High titre of antiglutamic acid decarboxylase autoantibody is a strong predictor of the development of thyroid autoimmunity in patients with type 1 diabetes and latent autoimmune diabetes in adults. Clin Endocrinol 74(5):587–592. doi:10.1111/j.1365-2265.2011.03976.x CrossRef

24.

Okruszko A, Szepietowska B, Wawrusiewicz-Kurylonek N, Gorska M, Kretowski A, Szelachowska M (2012) HLA-DR, HLA-DQB1 and PTPN22 gene polymorphism: association with age at onset for autoimmune diabetes. Arch Med Sci 8(5):874–878. doi:10.5114/aoms.2012.31619 PubMedCrossRefPubMedCentral

25.

Liu F, Liu J, Zheng TS, Li Q, Wang C, Pan XP, Lu H, Zhao YW (2012) The -1123G > C variant of PTPN22 gene promoter is associated with latent autoimmune diabetes in adult Chinese Hans. Cell Biochem Biophys 62(2):273–279. doi:10.1007/s12013-011-9291-4 PubMedCrossRef

26.

Haller K, Kisand K, Pisarev H, Salur L, Laisk T, Nemvalts V, Uibo R (2007) Insulin gene VNTR, CTLA-4 +49A/G and HLA-DQB1 alleles distinguish latent autoimmune diabetes in adults from type 1 diabetes and from type 2 diabetes group. Tissue Antigens 69(2):121–127. doi:10.1111/j.1399-0039.2006.00745.x PubMedCrossRef

27.

Caputo M, Cerrone GE, Lopez AP, Villalba A, Krochik GA, Cedola FN, Targovnik HM, Frechtel GD (2005) Cytotoxic T lymphocyte antigen 4 heterozygous codon 49 A/G dimorphism is associated to latent autoimmune diabetes in adults (LADA). Autoimmunity 38(4):277–281PubMedCrossRef

28.

Cosentino A, Gambelunghe G, Tortoioli C, Falorni A (2002) CTLA-4 gene polymorphism contributes to the genetic risk for latent autoimmune diabetes in adults. Ann N Y Acad Sci 958:337–340PubMedCrossRef

29.

Thakkinstian A, McKay GJ, McEvoy M, Chakravarthy U, Chakrabarti S, Silvestri G, Kaur I, Li X, Attia J (2011) Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis. Am J Epidemiol 173(12):1365–1379. doi:10.1093/aje/kwr025 PubMedCrossRef

30.

Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558. doi:10.1002/sim.1186 PubMedCrossRef

31.

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560. doi:10.1136/bmj.327.7414.557 PubMedCrossRefPubMedCentral

32.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177–188PubMedCrossRef

33.

Rossman MD, Thompson B, Frederick M, Maliarik M, Iannuzzi MC, Rybicki BA, Pandey JP, Newman LS, Magira E, Beznik-Cizman B, Monos D (2003) HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites. Am J Hum Genet 73(4):720–735. doi:10.1086/378097 PubMedCrossRefPubMedCentral

34.

Hayden KM, Zandi PP, Lyketsos CG, Tschanz JT, Norton MC, Khachaturian AS, Pieper CF, Welsh-Bohmer KA, Breitner JC (2005) Apolipoprotein E genotype and mortality: findings from the Cache County Study. J Am Geriatr Soc 53(6):935–942. doi:10.1111/j.1532-5415.2005.53301.x PubMedCrossRef

35.

Minelli C, Thompson JR, Abrams KR, Thakkinstian A, Attia J (2005) The choice of a genetic model in the meta-analysis of molecular association studies. Int J Epidemiol 34(6):1319–1328. doi:10.1093/ije/dyi169 PubMedCrossRef

36.

Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ (Clin res ed) 315(7109):629–634CrossRef

37.

Egger M, Smith GD, Altman DG (2008) Systematic reviews in health care: meta-analysis in context, 2nd ed. doi:10.1002/9780470693926

38.

Giza S, Goulas A, Gbandi E, Effraimidou S, Papadopoulou-Alataki E, Eboriadou M, Galli-Tsinopoulou A (2013) The role of PTPN22 C1858T gene polymorphism in diabetes mellitus type 1: first evaluation in Greek children and adolescents. BioMed res int 2013:721604. doi:10.1155/2013/721604 PubMedCrossRefPubMedCentral

39.

Fichna M, Zurawek M, Januszkiewicz-Lewandowska D, Fichna P, Nowak J (2010) PTPN22, PDCD1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Polish patients. Int J Immunogenet 37(5):367–372. doi:10.1111/j.1744-313X.2010.00935.x PubMedCrossRef

40.

Lavrikova E, Nikitin AG, Seregin IuA, Zil’berman LI, Tsitlidze NM, Kuraeva TL, Peterkova VA, Dedov II, Nosikov VV (2009) Association of the C1858T polymorphism of the PTPN22 gene with type 1 diabetes. Mol Biol 43(6):1040–1043CrossRef

41.

Philip B, Isabel W (2011) Association of cytotoxic T lymphocyte-associated antigen 4 gene single nucleotide polymorphism with type 1 diabetes mellitus in Madurai population of Southern India. Indian J Human Geneti 17(2):85–89. doi:10.4103/0971-6866.86189 CrossRef

42.

Ei Wafai RJ, Chmaisse HN, Makki RF, Fakhoury H (2011) Association of HLA class II alleles and CTLA-4 polymorphism with type 1 diabetes. Saudi J Kidney Dis Transpl 22(2):273–281PubMed

43.

Ahmedov G, Ahmedova L, Sedlakova P, Cinek O (2006) Genetic association of type 1 diabetes in an Azerbaijanian population: the HLA-DQ, -DRB1*04, the insulin gene, and CTLA4. Pediatric Diabetes 7(2):88–93. doi:10.1111/j.1399-543X.2006.00152.x PubMedCrossRef

44.

Alkhateeb A, Marzouka NA, Tashtoush R (2013) Variants in PTPN22 and SMOC2 genes and the risk of thyroid disease in the Jordanian Arab population. Endocrine. doi:10.1007/s12020-013-9908-z PubMed

45.

Gianchecchi E, Palombi M, Fierabracci A (2013) The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity. Autoimmun Rev 12(7):717–725. doi:10.1016/j.autrev.2012.12.003 PubMedCrossRef

46.

Spink C, Stege G, Tenbrock K, Harendza S (2013) The CTLA-4 +49GG genotype is associated with susceptibility for nephrotic kidney diseases. Nephrol Dialysis Transpl 28(11):2800–2805. doi:10.1093/ndt/gft381 CrossRef

47.

AlFadhli S (2013) Overexpression and secretion of the soluble CTLA-4 splice variant in various autoimmune diseases and in cases with overlapping autoimmunity. Genet Test Mol Biomark 17(4):336–341. doi:10.1089/gtmb.2012.0391 CrossRef

48.

Shi L, Wei Y, Xun W, Han D (2013) Meta-analysis of the correlation between PTPN22 gene polymorphisms and susceptibility to systemic lupus erythematosus. Asia-Pacific J Publ Health 25(4 Suppl):22S–29S. doi:10.1177/1010539513496268

49.

Xuan C, Lun LM, Zhao JX, Wang HW, Zhu BZ, Yu S, Liu Z, He GW (2013) PTPN22 gene polymorphism (C1858T) is associated with susceptibility to type 1 diabetes: a meta-analysis of 19,495 cases and 25,341 controls. Ann Hum Genet 77(3):191–203. doi:10.1111/ahg.12016 PubMedCrossRef

50.

Chen Z, Fei M, Fu D, Zhang L, Ma Y, Wang Y, Zhang F, Xia Q, Wang X (2013) Association between cytotoxic T lymphocyte antigen-4 polymorphism and type 1 diabetes: a meta-analysis. Gene 516(2):263–270. doi:10.1016/j.gene.2012.12.030 PubMedCrossRef

51.

Zhai JX, Zou LW, Zhang ZX, Fan WJ, Wang HY, Liu T, Ren Z, Dai RX, Ye D (2013) CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Mol Biol Rep 40(9):5213–5223. doi:10.1007/s11033-012-2125-7 PubMedCrossRef

52.

Mayer A, Fabien N, Gutowski MC, Dubois V, Gebuhrer L, Bienvenu J, Orgiazzi J, Madec AM (2007) Contrasting cellular and humoral autoimmunity associated with latent autoimmune diabetes in adults. Eur J Endocrinol 157(1):53–61. doi:10.1530/eje-07-0060 PubMedCrossRef

53.

Roh MO, Jung CH, Kim BY, Mok JO, Kim CH (2013) The prevalence and characteristics of latent autoimmune diabetes in adults (LADA) and its relation with chronic complications in a clinical department of a university hospital in Korea. Acta Diabetol 50(2):129–134. doi:10.1007/s00592-010-0228-y PubMedCrossRef

54.

Groop L, Tuomi T, Rowley M, Zimmet P, Mackay IR (2006) Latent autoimmune diabetes in adults (LADA)–more than a name. Diabetologia 49(9):1996–1998. doi:10.1007/s00125-006-0345-x PubMedCrossRef

55.

Jin P, Huang G, Lin J, Luo S, Zhou Z (2011) Epitope analysis of GAD65 autoantibodies in adult-onset type 1 diabetes and latent autoimmune diabetes in adults with thyroid autoimmunity. Acta Diabetol 48(2):149–155. doi:10.1007/s00592-010-0250-0 PubMedCrossRef

56.

Huang G, Wang X, Li Z, Li H, Li X, Zhou Z (2012) Insulin autoantibody could help to screen latent autoimmune diabetes in adults in phenotypic type 2 diabetes mellitus in Chinese. Acta Diabetol 49(5):327–331. doi:10.1007/s00592-010-0196-2 PubMedCrossRef

57.

Munafo MR, Flint J (2004) Meta-analysis of genetic association studies. Trends Genet 20(9):439–444. doi:10.1016/j.tig.2004.06.014 PubMedCrossRef

Title: The association of PTPN22 rs2476601 polymorphism and CTLA-4 rs231775 polymorphism with LADA risks: a systematic review and meta-analysis
Authors: Fang Dong
Guang Yang
Hong-Wei Pan
Wei-Huang Huang
Li-Peng Jing
Wen-Kai Liang
Na Zhang
Bao-Huan Zhang
Man Wang
Yang Liu
Li-Ju Zhang
Si-Heng Zhang
He Li
Chuan Chen
Li-Hong Nie
Chun-Xia Jing
Publication date: 01-10-2014
Publisher: Springer Milan
Published in: Acta Diabetologica / Issue 5/2014
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-014-0613-z

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