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01-06-2019 | Original Contribution

The association between the inflammatory potential of diet and risk of developing, and survival following, a diagnosis of ovarian cancer

Authors: C. M. Nagle, T. Ibiebele, N. Shivappa, J. R. Hébert, A. DeFazio, P. M. Webb, for the Australian Ovarian Cancer Study

Published in: European Journal of Nutrition | Issue 4/2019

Abstract

Purpose

Inflammation has been implicated in ovarian carcinogenesis. This study evaluated two dietary indices: the Dietary Inflammatory Index (DII®) and the Empirical Dietary Inflammatory Pattern (EDIP), in relation to risk of developing, and survival following, a diagnosis of ovarian cancer.

Methods

Data came from the Australian Ovarian Cancer Study (1375 cases, 1415 population controls). DII and EDIP scores were computed from dietary information obtained using a semiquantitative food-frequency questionnaire. Logistic regression was used to assess the association between DII and EDIP scores and risk of ovarian cancer and proportional hazards models were used for survival analysis.

Results

A high DII score, reflecting a more pro-inflammatory diet, was associated with a modest increased risk of ovarian cancer [odds ratio (OR) DII score_{Q4 vs.Q1} = 1.31, 95% CI 1.06–1.63, p_trend = 0.014]. Likewise a high EDIP score was associated with an increase in risk of ovarian cancer [OR EDIP score_{Q4 vs.Q1} = 1.39, 95% confidence interval (CI) 1.12–1.73, p_trend = 0.002]. We found no association between DII or EDIP score and overall or ovarian cancer-specific survival.

Conclusion

In conclusion, our results suggest that a pro-inflammatory diet modestly increases the risk of developing ovarian cancer.

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Title: The association between the inflammatory potential of diet and risk of developing, and survival following, a diagnosis of ovarian cancer
Authors: C. M. Nagle
T. Ibiebele
N. Shivappa
J. R. Hébert
A. DeFazio
P. M. Webb
for the Australian Ovarian Cancer Study
Publication date: 01-06-2019
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 4/2019
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-018-1779-x

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