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Malaria Journal
Published in: Malaria Journal 1/2012

Open Access 01-12-2012 | Review

The anaemia of Plasmodium vivax malaria

Authors: Nicholas M Douglas, Nicholas M Anstey, Pierre A Buffet, Jeanne R Poespoprodjo, Tsin W Yeo, Nicholas J White, Ric N Price

Published in: Malaria Journal | Issue 1/2012

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Abstract

Plasmodium vivax threatens nearly half the world’s population and is a significant impediment to achievement of the millennium development goals. It is an important, but incompletely understood, cause of anaemia. This review synthesizes current evidence on the epidemiology, pathogenesis, treatment and consequences of vivax-associated anaemia. Young children are at high risk of clinically significant and potentially severe vivax-associated anaemia, particularly in countries where transmission is intense and relapses are frequent. Despite reaching lower densities than Plasmodium falciparum, Plasmodium vivax causes similar absolute reduction in red blood cell mass because it results in proportionately greater removal of uninfected red blood cells. Severe vivax anaemia is associated with substantial indirect mortality and morbidity through impaired resilience to co-morbidities, obstetric complications and requirement for blood transfusion. Anaemia can be averted by early and effective anti-malarial treatment.
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Metadata
Title
The anaemia of Plasmodium vivax malaria
Authors
Nicholas M Douglas
Nicholas M Anstey
Pierre A Buffet
Jeanne R Poespoprodjo
Tsin W Yeo
Nicholas J White
Ric N Price
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2012
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-11-135

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