Skip to main content
Top
Published in: Heart Failure Reviews 2/2018

01-03-2018

Temporary assist device support for the right ventricle: pre-implant and post-implant challenges

Authors: Michael Dandel, Roland Hetzer

Published in: Heart Failure Reviews | Issue 2/2018

Login to get access

Abstract

Severe right ventricular (RV) failure is more likely reversible than similar magnitudes of left ventricular (LV) failure and, because reversal of both adaptive remodeling and impaired contractility require most often only short periods of support, the use of temporary RV assist devices (t-RVADs) can be a life-saving therapy option for many patients. Although increased experience with t-RVADs and progresses made in the development of safer devices with lower risk for complications has improved both recovery rate of RV function and patient survival, the mortality of t-RVAD recipients can still be high but it depends mainly on the primary cause of RV failure (RVF), the severity of end-organ dysfunction, and the timing of RVAD implantation, and much less on adverse events and complications related to RVAD implantation, support, or removal. Reduced survival of RVAD recipients should therefore not discourage appropriate application of RVADs because their underuse further reduces the chances for RV recovery and patient survival. The article reviews and discusses the challenges related to the pre-implant and post-implant decision-making processes aiming to get best possible therapeutic results. Special attention is focused on pre-implant RV assessment and prediction of RV improvement during mechanical unloading, patient selection for t-RVAD therapy, assessment of unloading-promoted RV recovery, and prediction of its stability after RVAD removal. Particular consideration is also given to prediction of RVF after LVAD implantation which is usually hampered by the complex interactions between the different risk factors related indirectly or directly to the RV potential for reverse remodeling and functional recovery.
Literature
1.
go back to reference Menzel T, Wagner S, Kramm T et al (2000) Pathophysiology of impaired right and left ventricular function in chronic embolic pulmonary hypertension: changes after pulmonary thromboendarterectomy. Chest 118(4):897–903CrossRefPubMed Menzel T, Wagner S, Kramm T et al (2000) Pathophysiology of impaired right and left ventricular function in chronic embolic pulmonary hypertension: changes after pulmonary thromboendarterectomy. Chest 118(4):897–903CrossRefPubMed
7.
go back to reference Moon MR, Bolger AF, DeAnda A et al (1997) Septal function during left ventricular unloading. Circulation 95:1320–1327CrossRefPubMed Moon MR, Bolger AF, DeAnda A et al (1997) Septal function during left ventricular unloading. Circulation 95:1320–1327CrossRefPubMed
8.
go back to reference Rajdev S, Benza R, Misra V (2007) Use of tandem heart as a temporary hemodynamic support option for severe pulmonary artery hypertension complicated by cardiogenic shock. J Invasive Cardiol 19(8):E226–E229PubMed Rajdev S, Benza R, Misra V (2007) Use of tandem heart as a temporary hemodynamic support option for severe pulmonary artery hypertension complicated by cardiogenic shock. J Invasive Cardiol 19(8):E226–E229PubMed
9.
go back to reference Rosenzweig EB, Chicotka S, Bacchetta M (2016) Right ventricular assist device use in ventricular failure due to pulmonary arterial hypertension: lessons learned. J Heart Lung Transplant 35(10):1272–1274CrossRefPubMed Rosenzweig EB, Chicotka S, Bacchetta M (2016) Right ventricular assist device use in ventricular failure due to pulmonary arterial hypertension: lessons learned. J Heart Lung Transplant 35(10):1272–1274CrossRefPubMed
16.
go back to reference Takayama H, Naka Y, Kodali SK (2012) A novel approach to percutaneous right ventricle mechanical support. Eur J Cardiothorac Surg 41(2):423–426CrossRefPubMed Takayama H, Naka Y, Kodali SK (2012) A novel approach to percutaneous right ventricle mechanical support. Eur J Cardiothorac Surg 41(2):423–426CrossRefPubMed
17.
go back to reference Haneya A, Philipp A, Puehler T et al (2012) Temporary percutaneous right ventricular support using a centrifugal pump in patients with postoperative acute refractory right ventricular failure after left ventricular assist device implantation. Eur J Cardiothorac Surg 41(1):219–223PubMed Haneya A, Philipp A, Puehler T et al (2012) Temporary percutaneous right ventricular support using a centrifugal pump in patients with postoperative acute refractory right ventricular failure after left ventricular assist device implantation. Eur J Cardiothorac Surg 41(1):219–223PubMed
19.
go back to reference Lazar JF, Swartz MF, Schiralli P et al (2013) Survival after left ventricular assist devices with and without temporary right ventricular support. Ann Thorac Surg 96:1155–1160CrossRef Lazar JF, Swartz MF, Schiralli P et al (2013) Survival after left ventricular assist devices with and without temporary right ventricular support. Ann Thorac Surg 96:1155–1160CrossRef
20.
go back to reference Krabatsch T, Potapov E, Stepanenko A et al (2011) Biventricular circulatory support with two miniaturized implantable assist devices. Circulation 124:S179–S186CrossRefPubMed Krabatsch T, Potapov E, Stepanenko A et al (2011) Biventricular circulatory support with two miniaturized implantable assist devices. Circulation 124:S179–S186CrossRefPubMed
27.
go back to reference Bernhardt AM, De By TM, Reichenspurner H, Deuse T (2015) Isolated permanent right ventricular assist device implantation with the HeartWare continuous-flow ventricular assist device: first results from the European Registry for Patients with Mechanical Circulatory Support. Eur J Cardiothorac Surg 48(1):158–162. https://doi.org/10.1093/ejcts/ezu406 CrossRefPubMed Bernhardt AM, De By TM, Reichenspurner H, Deuse T (2015) Isolated permanent right ventricular assist device implantation with the HeartWare continuous-flow ventricular assist device: first results from the European Registry for Patients with Mechanical Circulatory Support. Eur J Cardiothorac Surg 48(1):158–162. https://​doi.​org/​10.​1093/​ejcts/​ezu406 CrossRefPubMed
32.
go back to reference Schaefer A, Reichart D, Bernhardt AM et al (2017) Outcomes of minimally-invasive temporary RVAD support for acute right ventricular failure during minimal invasive LVAD implantation. ASAIO J 63(5):546–550CrossRefPubMed Schaefer A, Reichart D, Bernhardt AM et al (2017) Outcomes of minimally-invasive temporary RVAD support for acute right ventricular failure during minimal invasive LVAD implantation. ASAIO J 63(5):546–550CrossRefPubMed
35.
go back to reference Kapur NK, Paruchuri V, Korabathina R et al (2011) Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure. J Heart Lung Transplant 30:1360–1367CrossRefPubMed Kapur NK, Paruchuri V, Korabathina R et al (2011) Effects of a percutaneous mechanical circulatory support device for medically refractory right ventricular failure. J Heart Lung Transplant 30:1360–1367CrossRefPubMed
36.
go back to reference Shehab S, Macdonald PS, Kegh AM et al (2016) Long-term biventricular assist device support—serial cases of right atrial and right ventricular implantation outcomes. J Heart Lung Transplant 36:466–473CrossRef Shehab S, Macdonald PS, Kegh AM et al (2016) Long-term biventricular assist device support—serial cases of right atrial and right ventricular implantation outcomes. J Heart Lung Transplant 36:466–473CrossRef
38.
go back to reference Fitzpatrick JR, Frederick JR, Hiesinger W et al (2009) Early planned institution of biventricular circulatory support results in improved outcome compared with delayed conversion of a left ventricular assist device to a biventricular assist device. J Thorac Cardiovasc Surg 37:971–977CrossRef Fitzpatrick JR, Frederick JR, Hiesinger W et al (2009) Early planned institution of biventricular circulatory support results in improved outcome compared with delayed conversion of a left ventricular assist device to a biventricular assist device. J Thorac Cardiovasc Surg 37:971–977CrossRef
40.
go back to reference Kormos RL, Teutenberg JJ, Pagani FD et al (2010) Right ventricular failure in patients with the HeartMateII continuous flow left ventricular assist device: incidence, risk factors and effect on outcomes. J Thorac Cardiovasc Surg 139(5):1316–1324CrossRefPubMed Kormos RL, Teutenberg JJ, Pagani FD et al (2010) Right ventricular failure in patients with the HeartMateII continuous flow left ventricular assist device: incidence, risk factors and effect on outcomes. J Thorac Cardiovasc Surg 139(5):1316–1324CrossRefPubMed
43.
go back to reference Anavekar NS, Gerson D, Skali H et al (2007) Two-dimensional assessment of right ventricular function. An echocardiographic-MRI correlative study. Echocardiography 24:452–456CrossRefPubMed Anavekar NS, Gerson D, Skali H et al (2007) Two-dimensional assessment of right ventricular function. An echocardiographic-MRI correlative study. Echocardiography 24:452–456CrossRefPubMed
45.
go back to reference Focardi M, Cameli M, Carbone SF et al (2015) Traditional and innovative echocardiographic parameters for the analysis of right ventricular performance in comparison with cardiac magnetic resonance. Eur Heart J Cardiovasc Imaging 16:47–52CrossRefPubMed Focardi M, Cameli M, Carbone SF et al (2015) Traditional and innovative echocardiographic parameters for the analysis of right ventricular performance in comparison with cardiac magnetic resonance. Eur Heart J Cardiovasc Imaging 16:47–52CrossRefPubMed
48.
go back to reference Dandel M, Knosalla C, Kemper D et al (2015) Assessment of right ventricular adaptability to loading conditions can improve the timing of listing to transplantation in patients with pulmonary arterial hypertension. J Heart Lung Transplant 34(3):319–328CrossRefPubMed Dandel M, Knosalla C, Kemper D et al (2015) Assessment of right ventricular adaptability to loading conditions can improve the timing of listing to transplantation in patients with pulmonary arterial hypertension. J Heart Lung Transplant 34(3):319–328CrossRefPubMed
50.
go back to reference Cameli M, Bernazzali S, Lisi M et al (2012) Right ventricular longitudinal strain and right ventricular stroke work index in patients with severe heart failure: left ventricular assist device suitability for transplant candidates. Transplant Proc 44:2013–2015CrossRefPubMed Cameli M, Bernazzali S, Lisi M et al (2012) Right ventricular longitudinal strain and right ventricular stroke work index in patients with severe heart failure: left ventricular assist device suitability for transplant candidates. Transplant Proc 44:2013–2015CrossRefPubMed
52.
go back to reference Frea S, Bovolo V, Bergerone S et al (2012) Echocardiographic evaluation of right ventricular stroke work index in advanced heart failure: a new index? J Card Fail 18(12):886–889CrossRefPubMed Frea S, Bovolo V, Bergerone S et al (2012) Echocardiographic evaluation of right ventricular stroke work index in advanced heart failure: a new index? J Card Fail 18(12):886–889CrossRefPubMed
53.
go back to reference Guazzi M, Bandera F, Pelissero G et al (2013) Tricuspid annular systolic excursion and pulmonary artery pressure relationship in heart failure: an index of right ventricular function and prognosis. Am J Physiol Heart Circ Physiol 305(9):H1373–H1381CrossRefPubMed Guazzi M, Bandera F, Pelissero G et al (2013) Tricuspid annular systolic excursion and pulmonary artery pressure relationship in heart failure: an index of right ventricular function and prognosis. Am J Physiol Heart Circ Physiol 305(9):H1373–H1381CrossRefPubMed
54.
go back to reference Frea S, Pidello S, Bovolo V et al (2016) Prognostic incremental role of right ventricular function in acute decompensation of advanced chronic heart failure. Eur J Heart Fail 18:564–572CrossRefPubMed Frea S, Pidello S, Bovolo V et al (2016) Prognostic incremental role of right ventricular function in acute decompensation of advanced chronic heart failure. Eur J Heart Fail 18:564–572CrossRefPubMed
57.
go back to reference Barras N, Jeanrenaud X, Regamey J et al (2017) Right ventricular function before LVAD implantation. Cardiovascular Medicine - Kardiovaskuläre Medizin - Médicine Cardiovasculaire 20(3):69–71 Barras N, Jeanrenaud X, Regamey J et al (2017) Right ventricular function before LVAD implantation. Cardiovascular Medicine - Kardiovaskuläre Medizin - Médicine Cardiovasculaire 20(3):69–71
60.
go back to reference Lembcke A, Dohmen PM, Dewey M et al (2005) Multislice computed tomography for pre-operative evaluation of right ventricular volumes and function: comparison with magnetic resonance imaging. Ann Thorac Surg 79(4):1344–1351CrossRefPubMed Lembcke A, Dohmen PM, Dewey M et al (2005) Multislice computed tomography for pre-operative evaluation of right ventricular volumes and function: comparison with magnetic resonance imaging. Ann Thorac Surg 79(4):1344–1351CrossRefPubMed
61.
go back to reference Harjola V-P, Mebazzaa A, Celutkiene J et al (2016) Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. Eur J Heart Fail 18:226–241CrossRefPubMed Harjola V-P, Mebazzaa A, Celutkiene J et al (2016) Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. Eur J Heart Fail 18:226–241CrossRefPubMed
63.
go back to reference Ochiai Y, McCarthy PM, Smedira MG et al (2002) Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients. Circulation 106:I-198–I-202CrossRef Ochiai Y, McCarthy PM, Smedira MG et al (2002) Predictors of severe right ventricular failure after implantable left ventricular assist device insertion: analysis of 245 patients. Circulation 106:I-198–I-202CrossRef
64.
go back to reference Kukucka M, Potapov E, Stepaneko A et al (2011) Acute impact of left ventricular unloading by left ventricular assist device on right ventricle geometry and function: effect of nitric oxide inhalation. J Thorac Cardiovasc Surg 141:1009–1014CrossRefPubMed Kukucka M, Potapov E, Stepaneko A et al (2011) Acute impact of left ventricular unloading by left ventricular assist device on right ventricle geometry and function: effect of nitric oxide inhalation. J Thorac Cardiovasc Surg 141:1009–1014CrossRefPubMed
67.
go back to reference Alturi P, Fairman AS, MacArthur JW et al (2013) Continuous flow left ventricular assist device implant significantly improves pulmonary hypertension, right ventricular contractility and tricuspid valve competence. J Card Surg 28:770–775CrossRef Alturi P, Fairman AS, MacArthur JW et al (2013) Continuous flow left ventricular assist device implant significantly improves pulmonary hypertension, right ventricular contractility and tricuspid valve competence. J Card Surg 28:770–775CrossRef
77.
go back to reference Patil NP, Mohite PN, Sabashnikov A, Dhar D, Weymann A, Zeriouh M, Hards R, Hedger M, de Robertis F, Bahrami T, Amrani M, Rahman-Haley S, Banner NR, Popov AF, Simon AR (2015) Preoperative predictors and outcomes of right ventricular assist device implantation after continuous-flow left ventricular assist device implantation. J Thorac Cardiovasc Surg 150(6):1651–1658. https://doi.org/10.1016/j.jtcvs.2015.07.090 CrossRefPubMed Patil NP, Mohite PN, Sabashnikov A, Dhar D, Weymann A, Zeriouh M, Hards R, Hedger M, de Robertis F, Bahrami T, Amrani M, Rahman-Haley S, Banner NR, Popov AF, Simon AR (2015) Preoperative predictors and outcomes of right ventricular assist device implantation after continuous-flow left ventricular assist device implantation. J Thorac Cardiovasc Surg 150(6):1651–1658. https://​doi.​org/​10.​1016/​j.​jtcvs.​2015.​07.​090 CrossRefPubMed
78.
go back to reference Fan Y, Zhang A-M, Weng Y-G e a (2013) Factors associated with the need of biventricular mechanical circulatory support in children with advanced heart failure. Eur J Cardiothorac Surg 43:1128–1135CrossRef Fan Y, Zhang A-M, Weng Y-G e a (2013) Factors associated with the need of biventricular mechanical circulatory support in children with advanced heart failure. Eur J Cardiothorac Surg 43:1128–1135CrossRef
79.
go back to reference Lo C, Murphy D, Summerhyes R et al (2015) Right ventricular failure after implantation of continuous flow left ventricular assist devices: analysis of predictors and outcomes. Clin Transpl 29(9):763–770CrossRef Lo C, Murphy D, Summerhyes R et al (2015) Right ventricular failure after implantation of continuous flow left ventricular assist devices: analysis of predictors and outcomes. Clin Transpl 29(9):763–770CrossRef
80.
go back to reference Kalogeropoulos AP, Kelkar A, Weinberger JF et al (2015) Validation of clinical scores for right ventricular failure prediction after implantation of continuous-flow left ventricular assist devices. J Heart Lung Transplant 34(12):1595–1603CrossRefPubMed Kalogeropoulos AP, Kelkar A, Weinberger JF et al (2015) Validation of clinical scores for right ventricular failure prediction after implantation of continuous-flow left ventricular assist devices. J Heart Lung Transplant 34(12):1595–1603CrossRefPubMed
81.
go back to reference Nayak A, Neill C, Kormos RL et al (2017) Chemokine patterns and right heart failure in mechanical circulatory support. J Heart Lung Transplant 36(6):657–665CrossRefPubMed Nayak A, Neill C, Kormos RL et al (2017) Chemokine patterns and right heart failure in mechanical circulatory support. J Heart Lung Transplant 36(6):657–665CrossRefPubMed
83.
go back to reference Mazzucotelli J-P, Leprince P, Litzler P-Y et al (2011) Results of mechanical circulatory support in France. Eur J Cardiothorac Surg 40:e112–e117PubMed Mazzucotelli J-P, Leprince P, Litzler P-Y et al (2011) Results of mechanical circulatory support in France. Eur J Cardiothorac Surg 40:e112–e117PubMed
85.
go back to reference Akhter SA, Jeevanandam V (2012) Special clinical settings for mechanical circulatory support. In: Kormos RL, Miller LW (eds) Mechanical circulatory support. Elsevier Saunders, Philadelphia, pp 118–127 Akhter SA, Jeevanandam V (2012) Special clinical settings for mechanical circulatory support. In: Kormos RL, Miller LW (eds) Mechanical circulatory support. Elsevier Saunders, Philadelphia, pp 118–127
86.
go back to reference Houston BA, Kalathiya RJ, Hsu S, Loungani R, Davis ME, Coffin ST, Haglund N, Maltais S, Keebler ME, Leary PJ, Judge DP, Stevens GR, Rickard J, Sciortino CM, Whitman GJ, Shah AS, Russell SD, Tedford RJ (2016) Right ventricular afterload sensitivity dramatically increases after left ventricular device implantation: a multicenter hemodynamic analysis. J Heart Lung Transplant 35(7):868–876. https://doi.org/10.1016/j.healun.2016.01.1225 CrossRefPubMedPubMedCentral Houston BA, Kalathiya RJ, Hsu S, Loungani R, Davis ME, Coffin ST, Haglund N, Maltais S, Keebler ME, Leary PJ, Judge DP, Stevens GR, Rickard J, Sciortino CM, Whitman GJ, Shah AS, Russell SD, Tedford RJ (2016) Right ventricular afterload sensitivity dramatically increases after left ventricular device implantation: a multicenter hemodynamic analysis. J Heart Lung Transplant 35(7):868–876. https://​doi.​org/​10.​1016/​j.​healun.​2016.​01.​1225 CrossRefPubMedPubMedCentral
87.
go back to reference Dandel M, Potapov E, Krabatsch T et al (2011) Right ventricular assist device removal in patients with apparently unloading-promoted improvement of right ventricular function: Criteria for weaning decisions. Circulation 124(21Suppl):17718 Dandel M, Potapov E, Krabatsch T et al (2011) Right ventricular assist device removal in patients with apparently unloading-promoted improvement of right ventricular function: Criteria for weaning decisions. Circulation 124(21Suppl):17718
88.
Metadata
Title
Temporary assist device support for the right ventricle: pre-implant and post-implant challenges
Authors
Michael Dandel
Roland Hetzer
Publication date
01-03-2018
Publisher
Springer US
Published in
Heart Failure Reviews / Issue 2/2018
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-018-9678-z

Other articles of this Issue 2/2018

Heart Failure Reviews 2/2018 Go to the issue