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Neurotherapeutics
Published in: Neurotherapeutics 6/2022

01-10-2022 | Temperature Management | Current Perspectives

Through the Looking Glass: The Paradoxical Evolution of Targeted Temperature Management for Comatose Survivors of Cardiac Arrest

Authors: Salvatore A. D’Amato, W. Taylor Kimberly, Stephan A. Mayer

Published in: Neurotherapeutics | Issue 6/2022

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Abstract

For the past two decades, targeted temperature management (TTM) has been a staple in the care of comatose survivors following cardiac arrest. However, recent clinical trials have failed to replicate the benefit seen in earlier studies, bringing into question the very existence of such clinical practice. In this review, we explore clinical scenarios within critical care that appeared to share a similar fate, but in actuality changed the landscape of practice in a modern world. Accordingly, clinicians may apply these lessons to the utilization of TTM among comatose survivors following cardiac arrest, potentially paving way for a re-framing of clinical care amidst an environment where current data appears upside down in comparison to past successes.
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Metadata
Title
Through the Looking Glass: The Paradoxical Evolution of Targeted Temperature Management for Comatose Survivors of Cardiac Arrest
Authors
Salvatore A. D’Amato
W. Taylor Kimberly
Stephan A. Mayer
Publication date
01-10-2022
Publisher
Springer International Publishing
Published in
Neurotherapeutics / Issue 6/2022
Print ISSN: 1933-7213
Electronic ISSN: 1878-7479
DOI
https://doi.org/10.1007/s13311-022-01315-7

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