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Open Access 01-12-2021 | Temperature Management | Letter

Randomised trials of temperature management in cardiac arrest: Are we observing the Zeno’s paradox of the Tortoise and Achilles?

Authors: Tommaso Scquizzato, Paul J. Young, Giovanni Landoni, Luisa Zaraca, Alberto Zangrillo

Published in: Critical Care | Issue 1/2021

Excerpt

Initial trials published in 2002 found a benefit of therapeutic hypothermia at 32–34 °C in comatose adults resuscitated after cardiac arrest [1, 2]. Two decades after the publication of these practice-changing trials, a large multicentre randomised clinical trial (mRCT) found no benefit of temperature control at 33 °C compared to normothermia with active treatment of fever [3]. …

Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549–56.CrossRef

Bernard SA, Gray TW, Buist MD, Jones BM, Silvester W, Gutteridge G, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557–63.CrossRef

Dankiewicz J, Cronberg T, Lilja G, Jakobsen JC, Levin H, Ullén S, et al. Hypothermia versus normothermia after out-of-hospital cardiac arrest. N Engl J Med. 2021;384:2283–94.CrossRef

Landoni G, Pieri M, Young PJ, Bellomo R. Why do multicenter randomized controlled trials not confirm the positive findings of single center randomized controlled trials in acute care? Minerva Anestesiol. 2019;85:194–200.CrossRef

Taccone FS, Lascarrou J-B, Skrifvars MB. Targeted temperature management and cardiac arrest after the TTM-2 study. Crit Care. 2021;25:275.CrossRef

Title: Randomised trials of temperature management in cardiac arrest: Are we observing the Zeno’s paradox of the Tortoise and Achilles?
Authors: Tommaso Scquizzato
Paul J. Young
Giovanni Landoni
Luisa Zaraca
Alberto Zangrillo
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Temperature Management
Published in: Critical Care / Issue 1/2021
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-021-03826-9

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Randomised trials of temperature management in cardiac arrest: Are we observing the Zeno’s paradox of the Tortoise and Achilles?

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