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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2009

Open Access 01-12-2009 | Short report

Temozolomide and cisplatin in relapsed/refractory acute leukemia

Authors: Karen Seiter, Sreedhar Katragadda, Doris Ponce, Muhammad Rasul, Nasir Ahmed

Published in: Journal of Hematology & Oncology | Issue 1/2009

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Abstract

Cisplatin depletes MGMT and increases the sensitivity of leukemia cells to temozolomide. We performed a phase I study of cisplatin and temozolomide in patients with relapsed and refractory acute leukemia. Fifteen patients had AML, 3 had ALL, and 2 had biphenotypic leukemia. The median number of prior chemotherapy regimens was 3 (1–5). Treatment was well tolerated up to the maximal doses of temozolomide 200 mg/m2/d times 7 days and cisplatin 100 mg/m2 on day 1. There was one complete remission in this heavily pretreated patient population. Five of 20 (25%) patients demonstrated a significant reduction in bone marrow blasts.
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Metadata
Title
Temozolomide and cisplatin in relapsed/refractory acute leukemia
Authors
Karen Seiter
Sreedhar Katragadda
Doris Ponce
Muhammad Rasul
Nasir Ahmed
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2009
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/1756-8722-2-21

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