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Journal of Hematology & Oncology

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Open Access 01-12-2009 | Research

Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma

Authors: Yeng Chen, Boon-Kiong Lim, Onn H Hashim

Published in: Journal of Hematology & Oncology | Issue 1/2009

Abstract

Background

The general enhanced expression of α₁-antichymotrypsin (ACT), clusterin (CLU), α₁-antitrypsin (AAT), haptoglobin β-chain (HAP), and leucine rich glycoprotein (LRG) in the sera of patients with epithelial ovarian carcinoma (EOCa) was recently reported. In the present study, we compared the expression of the serum acute-phase proteins (APPs) in the patients according to their stages of cancer.

Results

Different altered stage correlative expression of the high abundance serum APPs was demonstrated in sera of the patients studied. While the expression of ACT, HAP and AAT appeared to demonstrate positive correlation with the three initial stages of the cancer, inverse correlation was apparently detected in the expression of LRG and CLU. For patients who were diagnosed with stage IV of the cancer, expression of the serum APPs did not conform to the altered progression changes.

Conclusion

Our results highlight the potential prognostic significance of selective high abundance serum APPs in patients with EOCa.

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Title: Different altered stage correlative expression of high abundance acute-phase proteins in sera of patients with epithelial ovarian carcinoma
Authors: Yeng Chen
Boon-Kiong Lim
Onn H Hashim
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2009
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/1756-8722-2-37

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