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Published in: Journal of Cancer Research and Clinical Oncology 10/2023

31-03-2023 | Targeted Therapy | Review

Small molecule inhibitors for cancer metabolism: promising prospects to be explored

Authors: Dan Liu, HongPing Wang, XingXing Li, JiFang Liu, YanLing Zhang, Jing Hu

Published in: Journal of Cancer Research and Clinical Oncology | Issue 10/2023

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Abstract

Background

Abnormal metabolism is the main hallmark of cancer, and cancer metabolism plays an important role in tumorigenesis, metastasis, and drug resistance. Therefore, studying the changes of tumor metabolic pathways is beneficial to find targets for the treatment of cancer diseases. The success of metabolism-targeted chemotherapy suggests that cancer metabolism research will provide potential new targets for the treatment of malignant tumors.

Purpose

The aim of this study was to systemically review recent research findings on targeted inhibitors of tumor metabolism. In addition, we summarized new insights into tumor metabolic reprogramming and discussed how to guide the exploration of new strategies for cancer-targeted therapy.

Conclusion

Cancer cells have shown various altered metabolic pathways, providing sufficient fuel for their survival. The combination of these pathways is considered to be a more useful method for screening multilateral pathways. Better understanding of the clinical research progress of small molecule inhibitors of potential targets of tumor metabolism will help to explore more effective cancer treatment strategies.
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Metadata
Title
Small molecule inhibitors for cancer metabolism: promising prospects to be explored
Authors
Dan Liu
HongPing Wang
XingXing Li
JiFang Liu
YanLing Zhang
Jing Hu
Publication date
31-03-2023
Publisher
Springer Berlin Heidelberg
Published in
Journal of Cancer Research and Clinical Oncology / Issue 10/2023
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-022-04501-4

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