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01-09-2010 | Original Article

TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population

Authors: Xiaoyang Ruan, Lina Ma, Shuyu Wang, Klaus Lindpaintner, Xiangjun Liu, Binbin Wang, Zuoqi Peng, Xu Ma, Maosheng Cheng, Jinghai Zhang, Lisheng Liu, Xingyu Wang

Published in: Acta Diabetologica | Issue 3/2010

Abstract

Associations between the TAQIB and I405V polymorphisms and obesity risk were studied for a single locus as well as in combination. A total of 934 obese subjects and 924 normal controls were included in the study. TAQIB was associated with high-density lipoprotein (HDL) levels (P < 0.001), while I405V was associated with levels of low-density lipoprotein (P = 0.03) and total cholesterol (P = 0.007). Less common alleles of TAQIB and I405V were associated with decreased obesity risk and further drops in odds ratio (OR) were observed in carriers with rare homozygous alleles on both loci (OR = 0.659, P = 0.02). The TAQIB B2 allele was associated with reductions in both hip circumference (P = 0.034) and triceps skinfold thickness (TST) (P = 0.045), although this effect was completely abolished after controlling for HDL levels. The 405V variant was associated with reductions in hip circumference (P = 0.031), body fat composition (P = 0.039) and TST (P = 0.036); these effects were weakened (P < 0.1) after controlling for HDL levels. In conclusion, less common alleles of TAQIB and I405V appear to be modestly associated with obesity risk in an adult Chinese population. Adjustments for HDL levels completely (TAQIB) or partially (I405V) abolished the observed association.

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Title: TAQIB and I405V polymorphisms of CETP are moderately associated with obesity risk in the Chinese adult population
Authors: Xiaoyang Ruan
Lina Ma
Shuyu Wang
Klaus Lindpaintner
Xiangjun Liu
Binbin Wang
Zuoqi Peng
Xu Ma
Maosheng Cheng
Jinghai Zhang
Lisheng Liu
Xingyu Wang
Publication date: 01-09-2010
Publisher: Springer Milan
Published in: Acta Diabetologica / Issue 3/2010
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-009-0117-4

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