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BMC Complementary Medicine and Therapies
Published in: BMC Complementary Medicine and Therapies 1/2024

Open Access 01-12-2024 | Tadalafile | Research

Novel drug therapy of acute hepatic failure induced in rats by a combination of tadalafil and Lepidium sativum

Authors: Mahmoud S. Sabra, Ahmed A. Mohammed, Khaled M. Ahmed Hassanein, Ahmed A. N. Ahmed, Dalia Hassan, Ebtsam S. Abdel-lah

Published in: BMC Complementary Medicine and Therapies | Issue 1/2024

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Abstract

Background

Hepatocyte death and a systemic inflammatory response are the outcome of a complex chain of events mediated by numerous inflammatory cells and chemical mediators. The point of this study was to find out if tadalafil and/or Lepidium sativum (L. sativum) could help people who have been exposed to carbon tetrachloride (CCL4) and are experiencing acute moderate liver failure. This was especially true when the two were used together.

Method and materials

To cause mild liver failure 24 h before sacrifice, a single oral dosage of CCL4 (2.5 mL/kg b.w.) (50% in olive oil) was utilized. Furthermore, immunohistochemical expression of nuclear factor kappa B (NF-κB) as well as histological abnormalities were performed on liver tissue.

Results

The results showed that tadalafil and/or L. sativum, especially in combination, performed well to cure acute mild liver failure caused by CCL4. This was demonstrated by a decrease in NF-κB expression in the liver tissue and an improvement in organ damage markers observed in the blood and liver tissues. Furthermore, such therapy reduced interleukin1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels in the liver tissue. It’s worth noting that the tested combination resulted in greater liver improvement.

Conclusions

According to the findings, tadalafil and L. sativum, particularly in combination, have the ability to protect the liver from the negative effects of CCL4 exposure. Because of its capacity to improve liver function, restore redox equilibrium, and decrease inflammatory mediators, it is a prospective option for mitigating the negative effects of common environmental pollutants such as CCL4.
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Metadata
Title
Novel drug therapy of acute hepatic failure induced in rats by a combination of tadalafil and Lepidium sativum
Authors
Mahmoud S. Sabra
Ahmed A. Mohammed
Khaled M. Ahmed Hassanein
Ahmed A. N. Ahmed
Dalia Hassan
Ebtsam S. Abdel-lah
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2024
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-024-04406-4

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