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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 10/2014

01-10-2014 | Correspondence

Tachykinin Peptide, Substance P, and Its Receptor Have a Significant Role in Tissue Reactions Induced by Cytotoxic Therapy

Authors: P. S. Satheeshkumar, Minu P. Mohan

Published in: Digestive Diseases and Sciences | Issue 10/2014

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Excerpt

We read with great interest the article by Matsumoto et al. [1] “Increased expression of 5-HT3 and NK-1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum.” The preclinical study showed that during 5-fluorouracil treatment, the mouse jejunum showed a threefold increase in the expression of the neurokinin-1 receptor (NK-1R), NK-1 receptor mRNA, and NK-1R immunoreactivity profile in mucosal inflammation. NK-1 receptor immunopositive cells were also increased in the lamina propria, and the expression of NK-1 receptor immunoreactivity increased in the deep muscular plexus of the mouse jejunum. The study identified a role of substance P (SP)/NK-1R in mucosal inflammation during biological treatment. …
Literature
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Matsumoto K, Nakajima T, Sakai H, et al. Increased expression of 5-HT3 and NK 1 receptors in 5-fluorouracil-induced mucositis in mouse jejunum. Dig Dis Sci. 2013;58:3440–3451.PubMedCrossRef
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Andrews PLR, Rudd JA. The role of tachykinins and the tachykinin NK1 receptor in nausea and emesis. In: Hofmann FB, ed. Handbook of Experimental Pharmacology. Berlin: Springer; 2004:359–440.
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Santini D, Vincenzi B, Guida FM, et al. Aprepitant for management of severe pruritus related to biological cancer treatments: a pilot study. Lancet Oncol. 2012;13:1020–1024.PubMedCrossRef
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Höckerfelt U, Franzén L, Forsgren S. Substance P (NK1) receptor in relation to substance P innervation in rat duodenum after irradiation. Regul Pept. 2001;98:115–126.PubMedCrossRef
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Forsgren S, Höckerfelt U, Norrgård O, Henriksson R, Franzén L. Pronounced substance P innervation in irradiation-induced enteropathy—a study on human colon. Regul Pept. 2000;88:1–13.PubMedCrossRef
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Yamamoto K, Kureyama N, Asano K, Ikeda T, Yamatodani A. Involvement of substance P and the neurokinin-1 receptor in radiation-induced hair loss in mice. J Pharmacol Sci. 2010;112:118–120.PubMedCrossRef
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Aalto Y, Forsgren S, Kjörell U, Franzén L, Gustafsson H, Henriksson R. Time- and dose-related changes in the expression of substance P in salivary glands in response to fractionated irradiation. Int J Radiat Oncol Biol Phys. 1995;33:297–305.PubMedCrossRef
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Lidegran M, Domeij S, Dalqvist Å, et al. Irradiation influences the expression of substance P and enkephalin in the rat larynx. Cell Tissue Res. 1995;279:55–63.PubMedCrossRef
Metadata
Title
Tachykinin Peptide, Substance P, and Its Receptor Have a Significant Role in Tissue Reactions Induced by Cytotoxic Therapy
Authors
P. S. Satheeshkumar
Minu P. Mohan
Publication date
01-10-2014
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 10/2014
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-014-3286-0

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