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01-06-2022 | Systemic Lupus Erythematosus | Review

Emerging Role of LncRNAs in Autoimmune Lupus

Authors: Wangdong Xu, Qian Wu, Anfang Huang

Published in: Inflammation | Issue 3/2022

Abstract

Long non-coding RNAs (lncRNAs) are a group of non-coding RNAs that have been considered as one of the largest and diverse RNA families. lncRNAs participate in dysregulation of post-transcriptional process by both RNA and protein interactions. This group of RNAs also plays essential roles in various cellular activities, such as differentiation, proliferation, and apoptosis. Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease, and evidence has suggested that many lncRNAs are involved in SLE pathogenesis, for instance, several lncRNAs were aberrantly expressed in SLE patients. Moreover, since post-transcriptional process by lncRNAs significantly performs in contributing to lupus progression, it is desirable to continue expanding the search for lncRNAs impacting on lupus development by post-transcriptional mechanisms. Highlighting the implication of lncRNAs in regulation of different immune cells through signaling pathways that have participated in SLE is of importance. Therefore, in this review, we summarized recent advances in lncRNAs and SLE. Hopefully, collection of the information will be better to comprehensively understand the relation of SLE and lncRNAs, and will have potential for investigating target for SLE regarding lncRNAs in the future.

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Title: Emerging Role of LncRNAs in Autoimmune Lupus
Authors: Wangdong Xu
Qian Wu
Anfang Huang
Publication date: 01-06-2022
Publisher: Springer US
Keyword: Systemic Lupus Erythematosus
Published in: Inflammation / Issue 3/2022
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-021-01607-8

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Aortic Wall Inflammation in the Pathogenesis, Diagnosis and Treatment of Aortic Aneurysms

Pink1/Parkin-Mediated Mitophagy Regulated the Apoptosis of Dendritic Cells in Sepsis

Enhanced Responsive Formation of Extracellular Traps in Macrophages Previously Exposed to Porphyromonas gingivalis

Enrichment of Newly Synthesized Proteins following treatment of C2C12 Myotubes with Endotoxin and Interferon-γ

LncRNA HCP5 Participates in the Tregs Functions in Allergic Rhinitis and Drives Airway Mucosal Inflammatory Response in the Nasal Epithelial Cells

Influence of Pinealectomy and Long-term Melatonin Administration on Inflammation and Oxidative Stress in Experimental Gouty Arthritis

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials