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Journal of Cardiovascular Translational Research

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01-12-2016 | Original Article

Systemic Delivery of Nanoparticles Loaded with Pentagalloyl Glucose Protects Elastic Lamina and Prevents Abdominal Aortic Aneurysm in Rats

Authors: Nasim Nosoudi, Aniqa Chowdhury, Steven Siclari, Vaideesh Parasaram, Saketh Karamched, Naren Vyavahare

Published in: Journal of Cardiovascular Translational Research | Issue 5-6/2016

Abstract

Degeneration of elastin plays a vital role in the pathology and progression of abdominal aortic aneurysm (AAA). Our previous study showed that pentagalloyl glucose (PGG), a core derivative of tannic acid, hinders the development of AAAs in a clinically relevant animal model when applied locally. In this study, we tested whether targeted nanoparticles (NPs) can deliver PGG to the site of an aneurysm and prevent aneurysmal growth by protecting elastin. PGG-loaded albumin NPs with a surface-conjugated elastin-specific antibody were prepared. Aneurysms were induced by calcium chloride-mediated injury to the abdominal aorta in rats. NPs were injected into the tail vein after 10 days of CaCl₂ injury. Rats were euthanized after 38 days. PGG delivery led to reduction in macrophage recruitment, matrix metalloproteinase (MMP) activity, elastin degradation, calcification, and development of aortic aneurysm. Such NP delivery offers the potential for the development of effective and safe therapies for AAA.

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Title: Systemic Delivery of Nanoparticles Loaded with Pentagalloyl Glucose Protects Elastic Lamina and Prevents Abdominal Aortic Aneurysm in Rats
Authors: Nasim Nosoudi
Aniqa Chowdhury
Steven Siclari
Vaideesh Parasaram
Saketh Karamched
Naren Vyavahare
Publication date: 01-12-2016
Publisher: Springer US
Published in: Journal of Cardiovascular Translational Research / Issue 5-6/2016
Print ISSN: 1937-5387
Electronic ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-016-9709-x

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Systemic Delivery of Nanoparticles Loaded with Pentagalloyl Glucose Protects Elastic Lamina and Prevents Abdominal Aortic Aneurysm in Rats

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