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Clinical and Translational Oncology
Published in: Clinical and Translational Oncology 11/2015

01-11-2015 | Research Article

Systemic chemotherapy as a main strategy for liver metastases from gastric cancer

Authors: W. Zhang, Y. Yu, Y. Fang, Y. Wang, Y. Cui, K. Shen, T. Liu

Published in: Clinical and Translational Oncology | Issue 11/2015

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Abstract

Background

Liver metastasis is associated with poor prognosis in gastric cancer. Surgical resection and systemic chemotherapy have been reported to be effective in gastric cancer with liver metastasis (GCLM). However, the best strategy for GCLM has not been established.

Methods

From May 2009 to July 2014, a consecutive series of GCLM patients in Zhongshan Hospital of Fudan University were studied. Treatment strategies were evaluated with regard to different extents of metastases.

Results

A total of 163 patients were included. The overall survival was 10.1 months. Active treatment significantly prolongs the survival of GCLM patients. The overall survival time for patients with liver-limited metastases and extra-hepatic liver metastases was 11.6 mo and 8.7 mo, respectively (P = 0.012). The median survival time for liver-limited disease of H1, H2 and H3 was 14.2, 15.8, and 8.5 months, respectively (H3 vs H2, P = 0.001; H3 vs H1, P = 0.000; H1 vs H2, P = 0.900). Systemic chemotherapy was chosen as the main strategy for the ‘extensive’ patients with extra-hepatic metastases and H3 type liver-limited metastases. Patients’ survival was benefited by multi-line chemotherapy. No differences were shown between systemic chemotherapy and curative resection or palliative resection in H1 and H2 liver-limited metastases (16.0 mo vs 12.0 mo, P = 0.711; 16.0 vs 18.8 months, P = 0.654).

Conclusion

Systemic chemotherapy was the main treatment for gastric cancer patients with liver metastases. Curative resection could be considered for highly selected patients.
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Metadata
Title
Systemic chemotherapy as a main strategy for liver metastases from gastric cancer
Authors
W. Zhang
Y. Yu
Y. Fang
Y. Wang
Y. Cui
K. Shen
T. Liu
Publication date
01-11-2015
Publisher
Springer Milan
Published in
Clinical and Translational Oncology / Issue 11/2015
Print ISSN: 1699-048X
Electronic ISSN: 1699-3055
DOI
https://doi.org/10.1007/s12094-015-1321-z

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