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01-08-2012 | Original Article

Long-term outcomes after surgical resection for gastric cancer liver metastasis: an analysis of 64 macroscopically complete resections

Authors: Nobuyuki Takemura, Akio Saiura, Rintaro Koga, Junichi Arita, Ryuji Yoshioka, Yoshihiro Ono, Naoki Hiki, Takeshi Sano, Junji Yamamoto, Norihiro Kokudo, Toshiharu Yamaguchi

Published in: Langenbeck's Archives of Surgery | Issue 6/2012

Abstract

Purpose

The indication for hepatectomy in cases of gastric cancer liver metastases (GLM) remains unclear and it remains controversial whether surgical resection is beneficial for GLM. The objective of this retrospective study was to clarify the indications for and benefit of hepatectomy for GLM.

Methods

Seventy-three patients underwent hepatectomies for GLM from January 1993 to January 2011. Macroscopically complete (R0 or R1) resection was achieved in 64 patients. Among them, 32 patients underwent synchronous hepatectomy with gastrectomy and the remaining 32 patients underwent metachronous hepatectomy. Repeat hepatectomy was done in 14 patients for resectable intrahepatic recurrences. Clinicopathological factors were evaluated by univariate and multivariate analyses among patients who received macroscopically complete resection for those affecting survival.

Results

The overall 1-, 3-, and 5-year survival rates after macroscopically complete (R0 or R1) liver resection (n = 64) for GLM were 84, 50, and 37 %, respectively, with a median survival of 34 months. Univariate analysis identified serosal invasion of the primary gastric cancer and blood transfusions during surgery as poor prognosis indicators. By multivariate analysis, serosal invasion of the primary gastric cancer and larger hepatic tumor (>5 cm in diameter) were found to be independent indicators of poor prognosis.

Conclusions

GLM patients with the maximum diameter of hepatic tumors of <5 cm and without serosal invasion of the primary gastric cancer are the best candidate for hepatectomy.

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Title: Long-term outcomes after surgical resection for gastric cancer liver metastasis: an analysis of 64 macroscopically complete resections
Authors: Nobuyuki Takemura
Akio Saiura
Rintaro Koga
Junichi Arita
Ryuji Yoshioka
Yoshihiro Ono
Naoki Hiki
Takeshi Sano
Junji Yamamoto
Norihiro Kokudo
Toshiharu Yamaguchi
Publication date: 01-08-2012
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 6/2012
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-012-0959-z

ACC 2024 Congress

Springer Medicine

Long-term outcomes after surgical resection for gastric cancer liver metastasis: an analysis of 64 macroscopically complete resections

Abstract

Purpose

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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