Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2017

Open Access 01-12-2017 | Research article

Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center

Authors: Marina de Tommaso, Vittorio Sciruicchio, Marianna Delussi, Eleonora Vecchio, Marvita Goffredo, Michele Simeone, Maria Grazia Foschino Barbaro

Published in: The Journal of Headache and Pain | Issue 1/2017

Login to get access

Abstract

Background

Central sensitization is an important epiphenomenon of the adult migraine, clinically expressed by allodynia, pericranial tenderness and comorbidity for fibromyalgia in a relevant number of patients. This study aimed to evaluate the frequency and the clinical characteristics of allodynia, pericranial tenderness, and comorbidity for Juvenile Fibromialgia (JFM) in a cohort of migraine children selected in a tertiary headache center.

Methods

This was an observational cross-sectional study on 8–15 years old migraine patients. Allodynia was assessed by a questionnaire. Pericranial tenderness and comorbidity for JFM as well as their possible association with poor quality of life and migraine related disability, and with other clinical symptoms as anxiety, depression, sleep disorders and pain catastrophizing, were also evaluated.

Results

One hundred and fifty one patients were selected, including chronic migraine (n°47), migraine without aura (n° 92) and migraine with aura (n° 12) sufferers. Allodynia was reported in the 96,6% and pericranial tenderness was observed in the 68.8% of patients. Pericranial tenderness was more severe in patients with more frequent migraine and shorter sleep duration. Allodynia seemed associated with anxiety, pain catastrophizing and high disability scores. Comorbidity for JFM was present in the 0.03% ofpatients. These children presented with a severe depression and a significant reduction of quality of life as compared to the other patients.

Conclusions

This study outlined a relevant presence of symptoms of central sensitization among children with migraine. Severe allodynia and comorbidity for JFM seemed to cause a general decline of quality of life, which would suggest the opportunity of a routine assessment of these clinical features.
Literature
1.
Stewart WF, Bigal ME, Kolodner K et al (2006) Familial risk of migraine: variation by proband age at onset and headache severity. Neurology 66(3):344–348CrossRefPubMed
2.
de Tommaso M, Sciruicchio V (2016) Migraine and central sensitization: clinical features, main comorbidities and therapeutic perspectives. Curr Rheumatol Rev 12(2):113–126CrossRefPubMed
3.
Headache Classification Committee of the International Headache Society (2013) The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia 33(9):629–808CrossRef
4.
Winner P, Hershey AD (2007) Epidemiology and diagnosis of migraine in children. Curr Pain Headache Rep 11:375–382CrossRefPubMed
5.
Burstein R, Yarnitsky D, Goor et al (2000) An association between migraine and cutaneous allodynia. Ann Neurol 2000(47):614–624CrossRef
6.
Bigal ME, Ashina S, Burstein R, Group AMPP et al (2008) Prevalence and characteristics of allodynia in headache sufferers: a population study. Neurology 70(17):1525–1533CrossRefPubMedPubMedCentral
7.
Louter MA, Bosker JE, van Oosterhout WP et al (2013) Cutaneous allodynia as a predictor of migraine chronification. Brain 136:3489–3496CrossRefPubMed
8.
de Tommaso M, Delussi M, Vecchio E, et al. (2014) Sleep features and central sensitization symptoms in primary headache patients. J Headache Pain 26:15:64.
9.
Ashkenazi A, Silberstein S, Jakubowski M, et al. (2007) Improved identification of allodynic migraine patients using a questionnaire.Cephalalgia 27: 325–329.
10.
Lipton RB, Bigal ME, Ashina S et al (2008) American Migraine Prevalence Prevention Advisory Group. Cutaneous allodynia in the migraine population. Ann Neurol 63(2):148–158CrossRefPubMedPubMedCentral
11.
Langermark M, Olesen J (1987) Pericranial tenderness in tension headache. a blind, controlled study. Cephalalgia 7:249–255CrossRef
12.
Buchgreitz L, Lyngberg AC, Bendtsen L et al (2006) Frequency of headache is related to sensitization: A population study. Pain 123:19–27CrossRefPubMed
13.
Eidlitz-Markus T, Shuper A, Gorali O, Zeharia A (2007) Migraine and cephalic cutaneous allodynia in pediatric patients. Headache 47:1219–1223CrossRefPubMed
14.
Raieli V, Trapolino D, Giordano G et al (2015) Juvenile migraine and allodynia: results of a retrospective study. Headache 55(3):413–418CrossRefPubMed
15.
Ferracini GN, Stuginsk-Barbosa J, Dach F et al (2014) A comparison pressure pain threshold in pericranial and extracephalic regions in children with migraine. Pain Med 15:702–709CrossRefPubMed
16.
de Tommaso M, Sciruicchio V, Ricci K et al (2016) Laser-evoked potential habituation and central sensitization symptoms in childhood migraine. Cephalalgia 36(5):463–473CrossRefPubMed
17.
Blaauw BA, Dyb G, Hagen K, Holmen TL, et al (2014) Anxiety, depression and behavioral problems among adolescents with recurrent headache: the Young-HUNT study. J Headache Pain 13:15:38.
18.
Yunus MB (2015) Editorial review: an update on central sensitivity syndromes and the issues of nosology and psychobiology. Curr Rheumatol Rev 11(2):70–85CrossRefPubMed
19.
Buskila D, Press J, Gedalia A, Klein M et al (1993) Assessment of nonarticular tenderness and prevalence of fibromyalgia in children. J Rheumatol 20(2):368–370PubMed
20.
Clark P, Burgos-Vargas R, Medina-Palma C, Lavielle P, Marina FF (1998) Prevalence of fibromyalgia in children: a clinical study of Mexican children. J Rheumatol 25(10):2009–2014PubMed
21.
Kashikar-Zuck S, King C, Ting TV, Arnold LM (2016) Juvenile Fibromyalgia: Different from the Adult Chronic Pain Syndrome? Curr Rheumatol Rep 18(4):19CrossRefPubMed
22.
Wolfe F, Clauw DJ, Fitzcharles MA et al (2010) The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 62:600–610CrossRef
23.
Ting TV, Barnett K, Lynch-Jordan A, Whitacre C, Henrickson M, Kashikar-Zuck S (2016) 2010 American College of Rheumatology adult fibromyalgia criteria for use in an adolescent female population with juvenile fibromyalgia. J Pediatr 169:181–187CrossRefPubMed
24.
de Tommaso M (2012) Prevalence, clinical features and potential therapies for fibromyalgia in primary headaches. Expert Rev Neurother 12(3):287–295CrossRefPubMed
25.
26.
D’Amico D, Grazzi L, Usai S et al (2003) Use of the Migraine Disability Assessment Questionnaire in children and adolescents with headache: An Italian pilot study. Headache 43:767–773CrossRefPubMed
27.
Trapanotto M, Giorgino D, Zulian F, Benini F, Varni JW (2009) The Italian version of the PedsQL in children with rheumatic diseases. Clin Exp Rheumatol 27(2):373–380PubMed
28.
Cianchetti, C., & Sannio Fancello, G. (2001) Scale psichiatriche di autosomministrazione per fanciulli e adolescenti (SAFA)[Psychiatric self-administration scales for youths and adolescents (SAFA)]. Firenze: Giunti O.S.
29.
Franzoni E, Monti M, Pellicciari A et al (2009) SAFA: A new measure to evaluate psychiatric symptoms detected in a sample of children and adolescents affected by eating disorders. Correlations with risk factors. Neuropsychiatr Dis Treat 5:207–214CrossRefPubMedPubMedCentral
30.
Bruni O, Salvatori O, Guidetti V et al (1996) The sleep disturbance scale for children (SDSC). Construction and validation of an instrument to evaluate sleep disturbances in childhood and adolescence. J Sleep Res 5:251–261CrossRefPubMed
31.
Crombez G, Bijttebier P, Eccleston C, Mascagni T et al (2003) The child version of the pain catastrophizing scale (PCS-C): a preliminary validation. Pain 104:639–646CrossRefPubMed
32.
Sullivan MJ, Thorn B, Haythornthwaite JA et al (2001) Theoretical perspectives on the relation between catastrophizing and pain. Clin J Pain 17:52–64CrossRefPubMed
33.
Özge A, Yalin OÖ (2016) Chronic migraine in children and adolescents. Curr Pain Headache Rep 20(2):14CrossRefPubMed
34.
Goldstein M, Chen TC (1982) The epidemiology of disabling headache. Adv Neurol 33:377–390PubMed
35.
36.
37.
Aytaçoğlu H, Özge A, Köstekçi İ, Taşdelen B, Öksüz B, Toros F (2011) The Effects of daily variables on primary headache disorders in high-school children; a proposal for a cut-off value for study/leisure time regarding headache types. J Neurol Sci Turk 29:453–464
38.
Miller VA, Palermo TM, Powers SW et al (2003) Migraine headaches and sleep disturbances in children. Headache 43:362–368CrossRefPubMed
39.
Bellini B, Arruda M, Cescut A, et al. (2013) Headache and comorbidity in children and adolescents. J Headache Pain. 24;14:79.
40.
Schwedt TJ, Larson-Prior L, Coalson RS (2014) Allodynia and Descending Pain Modulation in Migraine: A Resting State Functional Connectivity Analysis. Pain Med 15(1):154–165CrossRefPubMed
41.
Cahill CM, Cannon M (2005) The longitudinal relationship between comorbid migraine and psychiatric disorder. Cephalalgia 25:1099–1100CrossRefPubMed
42.
Guidetti V, Galli F, Fabrizi P, Giannantoni AS, Napoli L, Bruni O, Trillo S (1998) Headache and psychiatric comorbidity: clinical aspects and outcome in a 8-year follow-up study. Cephalalgia 18:455–462CrossRefPubMed
43.
Antonaci F, Nappi G, Galli F, Manzoni GC, Calabresi P, Costa A (2011) Migraine and psychiatric comorbidity: a review of clinical findings. J Headache Pain 12:115–125CrossRefPubMedPubMedCentral
44.
Lantéri-Minet M, Radat F, Chautart MH, Lucas C (2005) Anxiety and depression associated with migraine: Influence on migraine subjects’ disability and quality of life, and acute migraine management. Pain 118:319–332CrossRefPubMed
45.
Hansen MS, Wetterslev J, Pipper CB, Asghar MS, Dahl JB (2016) Is heat pain detection threshold associated with the area of secondary hyperalgesia following brief thermal sensitization? A study of healthy volunteers - design and detailed plan of analysis. BMC Anesthesiol 16(1):28CrossRefPubMedPubMedCentral
46.
Salomons TV, Moayedi M, Erpelding N, Davis KD (2014) A brief cognitive behavioural intervention for pain reduces secondary hyperalgesia. Pain 155(8):1446–1452CrossRefPubMed
47.
Trautmann E, Kröner-Herwig B (2010) A randomized controlled trial of Internet-based self-help training for recurrent headache in childhood and adolescence. Behav Res Ther 48(1):28–37CrossRefPubMed
48.
Gerloni V, Ghirardini M, Fantini F (1998) Assessment of nonarticular tenderness and prevalence of primary fibromyalgia syndrome in healthy Italian schoolchildren. Arthritis Rheum 41(9):1405
49.
Cunningham NR, Tran ST, Lynch-Jordan AM et al (2015) Psychiatric disorders in young adults diagnosed with juvenile fibromyalgia in adolescence. J Rheumatol 42(12):2427–2433CrossRefPubMedPubMedCentral
Metadata
Title
Symptoms of central sensitization and comorbidity for juvenile fibromyalgia in childhood migraine: an observational study in a tertiary headache center
Authors
Marina de Tommaso
Vittorio Sciruicchio
Marianna Delussi
Eleonora Vecchio
Marvita Goffredo
Michele Simeone
Maria Grazia Foschino Barbaro
Publication date
01-12-2017
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2017
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-017-0764-8

Other articles of this Issue 1/2017

The Journal of Headache and Pain 1/2017 Go to the issue

Research article

Patients’ preferences for headache acute and preventive treatment

Research article

Volume expansion of periaqueductal gray in episodic migraine: a pilot MRI structural imaging study

Research article

Frequent mild head injury promotes trigeminal sensitivity concomitant with microglial proliferation, astrocytosis, and increased neuropeptide levels in the trigeminal pain system

Erratum

Erratum to: 1st Joint ANIRCEF-SISC Congress (meeting abstracts)

Research article

The association of headache frequency with pain interference and the burden of disease is mediated by depression and sleep quality, but not anxiety, in chronic tension type headache

Research article

Duration and frequency of migraines affect cognitive function: evidence from neuropsychological tests and event-related potentials