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Neurocritical Care

15-04-2024 | Review Article

Survivorship After Neurocritical Care: A Scoping Review of Outcomes Beyond Physical Status

Authors: Jamie Nicole LaBuzetta, Dale N. Bongbong, Eric Mlodzinski, Richa Sheth, Aaron Trando, Nicholas Ibrahim, Brandon Yip, Atul Malhotra, Victor D. Dinglas, Dale M. Needham, Biren B. Kamdar

Published in: Neurocritical Care

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Abstract

Following intensive care unit hospitalization, survivors of acute neurological injury often experience debilitating short-term and long-term impairments. Although the physical/motor impairments experienced by survivors of acute neurological injury have been described extensively, fewer studies have examined cognitive, mental health, health-related quality of life (HRQoL), and employment outcomes. This scoping review describes the publication landscape beyond physical and/or motor sequelae in neurocritical care survivors. Databases were searched for terms related to critical illness, intensive care, and outcomes from January 1970 to March 2022. English-language studies of critically ill adults with a primary neurological diagnosis were included if they reported on at least one outcome of interest: cognition, mental health, HRQoL or employment. Data extraction was performed in duplicate for prespecified variables related to study outcomes. Of 16,036 abstracts screened, 74 citations were identified for inclusion. The studies encompassed seven worldwide regions and eight neurocritical diagnosis categories. Publications reporting outcomes of interest increased from 3 before the year 2000 to 71 after. Follow-up time points included ≤ 1 (n = 15 [20%] citations), 3 (n = 28 [38%]), 6 (n = 28 [38%]), and 12 (n = 21 [28%]) months and 1 to 5 (n = 19 [26%]) and > 5 years (n = 8 [11%]), with 28 (38%) citations evaluating outcomes at multiple time points. Sixty-six assessment tools were used to evaluate the four outcomes of interest: 22 evaluating HRQoL (56 [76%] citations), 21 evaluating cognition (20 [27%] citations), 21 evaluating mental health (18 [24%] citations), and 2 evaluating employment (9 [12%] citations). This scoping review aimed to better understand the literature landscape regarding nonphysical outcomes in survivors of neurocritical care. Although a rising number of publications highlight growing awareness, future efforts are needed to improve study consistency and comparability and characterize outcomes in a disease-specific manner, including outlining of a minimum core outcomes set and associated assessment tools.
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Metadata
Title
Survivorship After Neurocritical Care: A Scoping Review of Outcomes Beyond Physical Status
Authors
Jamie Nicole LaBuzetta
Dale N. Bongbong
Eric Mlodzinski
Richa Sheth
Aaron Trando
Nicholas Ibrahim
Brandon Yip
Atul Malhotra
Victor D. Dinglas
Dale M. Needham
Biren B. Kamdar
Publication date
15-04-2024
Publisher
Springer US
Published in
Neurocritical Care
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-024-01965-9