Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2015

Open Access 01-12-2015 | Research

Survivin and angiotensin-converting enzyme polymorphisms with risk of colorectal cancer: a systematic review and meta-analysis

Authors: Xile Zhou, Caizhao Lin

Published in: World Journal of Surgical Oncology | Issue 1/2015

Login to get access

Abstract

Background

Colorectal cancer (CRC) is the most common cause of cancer death worldwide. Numerous studies have identified the roles of survivin −31 G/C and angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms in CRC risk; however, the results remain inconclusive. This study was to investigate associations between these two polymorphisms and CRC susceptibility.

Methods

A comprehensive literature search was conducted to collect relevant case–control studies published between 2000 and 2014. The extracted data were statistically analyzed, and the odds ratios (ORs) with 95% confidence intervals (CIs) were employed to estimate the strength of association.

Results

A total of 11 studies were included in the meta-analysis. For survivin G/C polymorphism, six articles reported 1,840 cases and 1,804 controls. Overall, we found the frequency of C allele is higher in CRC cases than that in the healthy controls (57.2% vs. 48.0%), and C allele significantly increased the risk of CRC compared to G allele in allele model (OR = 1.46, 95% CI = 1.33–1.60, P < 0.00001). This association was also found in other genetic models (P < 0.00001). Stratified analysis by ethnicity showed significant association in each genetic model among the Asian population. For ACE I/D polymorphism, five studies included 758 cases and 6,755 controls. No significant association was found in any genetic models.

Conclusions

Our results showed that survivin −31 G/C polymorphism might contribute to risk of CRC, especially in the Asian populations. However, the ACE I/D polymorphism is not a genetic factor concerning the risk for CRC. More studies with larger sample sizes are required in the future.
Literature
1.
Wasserman M, Baxter N, Rosen B, Burnstein M, Halverson A. Systematic review of internet patient information on colorectal cancer surgery. Dis Colon Rectum. 2014;57(1):64–9.CrossRefPubMed
2.
Mäkinen MJ. Serrated polyps and colorectal cancer risk. Colorectal Cancer. 2014;3(1):77–91.CrossRef
3.
Siegel R, DeSantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin. 2014;64(2):104–17.CrossRefPubMed
4.
Derks S, van Engeland M. Epigenetic disturbances in colorectal cancer. Epigenetic Therapy of Cancer. Springer; 2014. p. 283–98.
5.
6.
7.
Altieri DC. Survivin, cancer networks and pathway-directed drug discovery. Nat Rev Cancer. 2008;8(1):61–70.CrossRefPubMed
8.
Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med. 1997;3(8):917–21.CrossRefPubMed
9.
Antonacopoulou AG, Floratou K, Bravou V, Kottorou A, Dimitrakopoulos F-I, Marousi S, et al. The survivin-31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival. Cell Oncol. 2011;34(4):381–91.CrossRef
10.
Krege JH, Kim H-S, Moyer JS, Jennette JC, Peng L, Hiller SK, et al. Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension. 1997;29(1):150–7.CrossRefPubMed
11.
Feng Y, Wan H, Liu J, Zhang R, Ma Q, Han B, et al. The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer. Oncol Rep. 2010;23(4):941–8.PubMed
12.
Zhang Y, He J, Deng Y, Zhang J, Li X, Xiang Z, et al. The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene and cancer risk: a meta-analysis. BMC Med Genet. 2011;12(1):159.CrossRefPubMedCentralPubMed
13.
Mc Menamin ÚC, Murray LJ, Cantwell MM, Hughes CM. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in cancer progression and survival: a systematic review. Cancer Causes Control. 2012;23(2):221–30.CrossRefPubMed
14.
15.
Sameer A, Nissar S, Bashir S, Bashir A, Siddiqi M. ACE polymorphism in colorectal cancer patients of Kashmiri population—a short report. Open Colorectal Canc J. 2011;4:1–5.CrossRef
16.
Gazouli M, Tzanakis N, Rallis G, Theodoropoulos G, Papaconstantinou I, Kostakis A, et al. Survivin −31G/C promoter polymorphism and sporadic colorectal cancer. Int J Colorectal Dis. 2009;24(2):145–50.CrossRefPubMed
17.
Huang J, Wang J, Wang L, Liu H, Wei Y, Huang M, et al. Association between Survivin Promoter -31C/G Polymorphism and Genetic Susceptibility to Sporadic Colorectal Cancer. J SUN Yat-sen Univ (Med Sci). 2010;31(1):59–63 (in chinese).
18.
Duan F. The Study on the Relationship between Survivin promoter SNP and the Colorectal Cancer. Master's thesis. Lu Zhou medical college, 2012. (in chinese)
19.
Liu Y. The Association of Survivin Polymorphism with the Risk of Colorectal Cancer. Master's thesis. Hebei medical college, 2012. (in chinese)
20.
Li XB, Li SN, Yang ZH, Cao L, Duan FL, Sun XW. Polymorphisms of survivin and its protein expression are associated with colorectal cancer susceptibility in Chinese population. DNA Cell Biol. 2013;32(5):236–42.CrossRefPubMedCentralPubMed
21.
Nikiteas N, Tsigris C, Chatzitheofylaktou A, Yannopoulos A. No association with risk for colorectal cancer of the insertion/deletion polymorphism which affects levels of angiotensin-converting enzyme. In Vivo. 2007;21(6):1065–68.PubMed
22.
Rocken C, Neumann K, Carl-McGrath S, Lage H, Ebert MP, Dierkes J, et al. The gene polymorphism of the angiotensin I-converting enzyme correlates with tumor size and patient survival in colorectal cancer patients. Neoplasia. 2007;9(9):716–22.CrossRefPubMedCentralPubMed
23.
Van der Knaap R, Siemes C, Coebergh JW, Van Duijn CM, Hofman A, Stricker BH. Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: the Rotterdam Study. Cancer. 2008;112(4):748–57.CrossRefPubMed
24.
Toma M, Cimponeriu D, Apostol P, Stavarachi M, Cojocaru M, Belusica L, et al. Lack of association between ACE ID polymorphism and colorectal cancer in Romanian patients. Chirurgia (Bucharest, Romania: 1990). 2008;104(5):553–56.
25.
Liu SY, Sima X, Wang CH, Gao M. The association between ACE polymorphism and risk of colorectal cancer in a Chinese population. Clin Biochem. 2011;44(14):1223–26.CrossRefPubMed
26.
Casati C, Dalerba P, Rivoltini L, Gallino G, Deho P, Rini F, et al. The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients. Cancer Res. 2003;63(15):4507–15.PubMed
27.
Kawasaki H, Toyoda M, Shinohara H, Okuda J, Watanabe I, Yamamoto T, et al. Expression of survivin correlates with apoptosis, proliferation, and angiogenesis during human colorectal tumorigenesis. Cancer. 2001;91(11):2026–32.CrossRefPubMed
28.
Fan L-F, Dong W-G, Jiang C-Q, Qian Q, Yu Q-F. Role of hypoxia-inducible factor-1α and survivin in colorectal carcinoma progression. Int J Color Dis. 2008;23(11):1057–64.CrossRef
29.
Jang JS, Kim KM, Kang KH, Choi JE, Lee WK, Kim CH, et al. Polymorphisms in the < i > survivin </i > gene and the risk of lung cancer. Lung Cancer. 2008;60(1):31–9.CrossRefPubMed
30.
Qin Q, Zhang C, Zhu H, Yang X, Xu L, Liu J, et al. Association between survivin-31G > C polymorphism and cancer risk: meta-analysis of 29 studies. J Cancer Res Clin Oncol. 2014;140(2):179–88.CrossRefPubMed
31.
32.
Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, et al. An IAP-IAP complex inhibits apoptosis. J Biol Chem. 2004;279(33):34087–90.CrossRefPubMed
33.
Chu XY, Chen LB, Wang JH, Su QS, Yang JR, Lin Y, et al. Overexpression of survivin is correlated with increased invasion and metastasis of colorectal cancer. J Surg Oncol. 2012;105(6):520–8.CrossRefPubMed
34.
Choi J, Chang H. The expression of MAGE and SSX, and correlation of COX2, VEGF, and survivin in colorectal cancer. Anticancer Res. 2012;32(2):559–64.PubMed
35.
Kim PJ, Plescia J, Clevers H, Fearon ER, Altieri DC. Survivin and molecular pathogenesis of colorectal cancer. Lancet. 2003;362(9379):205–9.CrossRefPubMed
36.
Ma Y, Wang HS. Correlations of Bcl-2 and survivin gene protein expressions in colorectal cancer. Appl Mech Mater. 2013;423:362–5.CrossRef
37.
Goossens-Beumer I, Zeestraten E, Benard A, Christen T, Reimers M, Keijzer R, et al. Clinical prognostic value of combined analysis of Aldh1, survivin, and EpCAM expression in colorectal cancer. Br J Cancer. 2014;110(12):2935–44.CrossRefPubMed
38.
39.
Hernandez JM, Farma JM, Coppola D, Hakam A, Fulp WJ, Chen D-T, et al. Expression of the antiapoptotic protein survivin in colon cancer. Clin Colorectal Cancer. 2011;10(3):188–93.CrossRefPubMed
40.
Krieg A, Werner TA, Verde PE, Stoecklein NH, Knoefel WT. Prognostic and clinicopathological significance of survivin in colorectal cancer: a meta-analysis. PLoS One. 2013;8(6):e65338.CrossRefPubMedCentralPubMed
41.
Guang C, Phillips RD, Jiang B, Milani F. Three key proteases–angiotensin-I-converting enzyme (ACE), ACE2 and renin—within and beyond the renin-angiotensin system. Arch Cardiovasc Dis. 2012;105(6):373–85.CrossRefPubMed
42.
Yates CJ, Masuyer G, Schwager SL, Akif M, Sturrock ED, Acharya KR. Molecular and thermodynamic mechanisms of the chloride-dependent human angiotensin-I-converting enzyme (ACE). J Biol Chem. 2014;289(3):1798–814.CrossRefPubMedCentralPubMed
43.
Xie Y, You C, Chen J. An updated meta-analysis on association between angiotensin I-converting enzyme gene insertion/deletion polymorphism and cancer risk. Tumor Biol. 2014;35(7):6567–79.CrossRef
44.
Yuan F, Zhang L-S, Li H-Y, Liao M, Lv M, Zhang C. Influence of angiotensin I-converting enzyme gene polymorphism on hepatocellular carcinoma risk in China. DNA Cell Biol. 2013;32(5):268–73.CrossRefPubMedCentralPubMed
45.
Liu J-F, Xie H-J, Cheng T-M. Lack of any association between insertion/deletion (I/D) polymorphisms in the angiotensin-converting enzyme gene and digestive system cancer risk: a meta-analysis. Asian Pac J Cancer Prev. 2013;14(12):7271–5.CrossRefPubMed
Metadata
Title
Survivin and angiotensin-converting enzyme polymorphisms with risk of colorectal cancer: a systematic review and meta-analysis
Authors
Xile Zhou
Caizhao Lin
Publication date
01-12-2015
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-015-0461-5

Other articles of this Issue 1/2015

World Journal of Surgical Oncology 1/2015 Go to the issue

Research

Meta-analysis of associations between neutrophil-to-lymphocyte ratio and prognosis of gastric cancer

Research

Incidentalomas during imaging for primary hyperparathyroidism—incidence and clinical outcomes

Research

Follicular thyroid carcinoma: differences in clinical relevance between minimally invasive and widely invasive tumors

Research

Clear cell carcinoma of the ovary: multi-slice computed tomography findings

Research

SUVmax of 18F-FDG PET/CT in the differential diagnosis of benign and malignant thyroid nodules according to tumor volume

OriginalPaper

Intestinal intussusception in a young women: unusual cause and specific management