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Trials
Published in: Trials 1/2015

Open Access 01-12-2015 | Study protocol

Surgical techniques, open versus minimally invasive gastrectomy after chemotherapy (STOMACH trial): study protocol for a randomized controlled trial

Authors: Jennifer Straatman, Nicole van der Wielen, Miguel A Cuesta, Suzanne S Gisbertz, Koen J Hartemink, Alfredo Alonso Poza, Jürgen Weitz, Fransico Mateo Vallejo, Khurshid Ahktar, Ismael Diez del Val, Josep Roig Garcia, Donald L van der Peet

Published in: Trials | Issue 1/2015

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Abstract

Background

Laparoscopic surgery has been shown to provide important advantages in comparison with open procedures in the treatment of several malignant diseases, such as less perioperative blood loss and faster patient recovery. It also maintains similar results with regard to tumor resection margins and oncological long-term survival. In gastric cancer the role of laparoscopic surgery remains unclear.
Current recommended treatment for gastric cancer consists of radical resection of the stomach, with a free margin of 5 to 6 cm from the tumor, combined with a lymphadenectomy. The extent of the lymphadenectomy is considered a marker for radicality of surgery and quality of care. Therefore, it is imperative that a novel surgical technique, such as minimally invasive total gastrectomy, should be non-inferior with regard to radicality of surgery and lymph node yield.

Methods/Design

The Surgical Techniques, Open versus Minimally invasive gastrectomy After CHemotherapy (STOMACH) study is a randomized, clinical multicenter trial. All adult patients with primary carcinoma of the stomach, in which the tumor is considered surgically resectable (T1-3, N0-1, M0) after neo-adjuvant chemotherapy, are eligible for inclusion and randomization. The primary endpoint is quality of oncological resection, measured by radicality of surgery and number of retrieved lymph nodes. The pathologist is blinded towards patient allocation. Secondary outcomes include patient-reported outcomes measures (PROMs) regarding quality of life, postoperative complications and cost-effectiveness. Based on a non-inferiority model for lymph node yield, with an average lymph node yield of 20, a non-inferiority margin of −4 and a 90% power to detect non-inferiority, a total of 168 patients are to be included.

Discussion

The STOMACH trial is a prospective, multicenter, parallel randomized study to define the optimal surgical strategy in patients with proximal or central gastric cancer after neo-adjuvant therapy: the conventional ‘open’ approach or minimally invasive total gastrectomy.

Trial registration

This trial was registered on 28 April 2014 at Clinicaltrials.gov with the identifier NCT02130726.
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Metadata
Title
Surgical techniques, open versus minimally invasive gastrectomy after chemotherapy (STOMACH trial): study protocol for a randomized controlled trial
Authors
Jennifer Straatman
Nicole van der Wielen
Miguel A Cuesta
Suzanne S Gisbertz
Koen J Hartemink
Alfredo Alonso Poza
Jürgen Weitz
Fransico Mateo Vallejo
Khurshid Ahktar
Ismael Diez del Val
Josep Roig Garcia
Donald L van der Peet
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Trials / Issue 1/2015
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-015-0638-9

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