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Published in: Journal of Translational Medicine 1/2009

Open Access 01-12-2009 | Review

Surgical inflammation: a pathophysiological rainbow

Authors: Jose-Ignacio Arias, María-Angeles Aller, Jaime Arias

Published in: Journal of Translational Medicine | Issue 1/2009

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Abstract

Tetrapyrrole molecules are distributed in virtually all living organisms on Earth. In mammals, tetrapyrrole end products are closely linked to oxygen metabolism. Since increasingly complex trophic functional systems for using oxygen are considered in the post-traumatic inflammatory response, it can be suggested that tetrapyrrole molecules and, particularly their derived pigments, play a key role in modulating inflammation.
In this way, the diverse colorfulness that the inflammatory response triggers during its evolution would reflect the major pathophysiological importance of these pigments in each one of its phases. Therefore, the need of exploiting this color resource could be considered for both the diagnosis and treatment of the inflammation.
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Literature
1.
go back to reference Kohl BA, Deutschman CS: The inflammatory response to surgery and trauma. Curr Opin Crit Care. 2006, 12: 325-332.PubMed Kohl BA, Deutschman CS: The inflammatory response to surgery and trauma. Curr Opin Crit Care. 2006, 12: 325-332.PubMed
2.
go back to reference Aller MA, Arias JL, Nava MP, Arias J: Post-traumatic inflammation is a complex response based on the pathological expression of the nervous, immune and endocrine functional systems. Exp Biol Med. 2004, 229: 170-181. Aller MA, Arias JL, Nava MP, Arias J: Post-traumatic inflammation is a complex response based on the pathological expression of the nervous, immune and endocrine functional systems. Exp Biol Med. 2004, 229: 170-181.
3.
go back to reference Punchard NA, Whelan CJ, Adcock I: The journal of inflammation. J Inflamm (Lond). 2004, 1: 1- Punchard NA, Whelan CJ, Adcock I: The journal of inflammation. J Inflamm (Lond). 2004, 1: 1-
4.
go back to reference Aller MA, Arias JL, Sanchez-Patan F, Arias J: The inflammatory response: An efficient way of life. Med Sci Monit. 2006, 12: RA225-234.PubMed Aller MA, Arias JL, Sanchez-Patan F, Arias J: The inflammatory response: An efficient way of life. Med Sci Monit. 2006, 12: RA225-234.PubMed
6.
go back to reference Arias J, Aller MA, Arias JI, Lorente L: Traumatismos mecánicos: Contusión. Herida. Fractura. Fisiopatología Quirúrgica. Edited by: Arias J, Aller MA, Arias JI, Lorente L. 1999, Madrid: Ed. Tébar, Chapter 2: 35-49. Arias J, Aller MA, Arias JI, Lorente L: Traumatismos mecánicos: Contusión. Herida. Fractura. Fisiopatología Quirúrgica. Edited by: Arias J, Aller MA, Arias JI, Lorente L. 1999, Madrid: Ed. Tébar, Chapter 2: 35-49.
7.
go back to reference Velde Vande C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, Hakem R, Greenberg AH: BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol. 2000, 20: 5454-5468. Velde Vande C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, Hakem R, Greenberg AH: BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol. 2000, 20: 5454-5468.
8.
go back to reference Jin Z, El-Deiry WS: Overview of cell death signaling pathways. Cancer Biol & Ther. 2005, 4: 139-163. Jin Z, El-Deiry WS: Overview of cell death signaling pathways. Cancer Biol & Ther. 2005, 4: 139-163.
9.
go back to reference Rosser BG, Gores GJ: Liver cell necrosis: Cellular mechanisms and clinical implications. Gastroenterology. 1995, 108: 252-275.PubMed Rosser BG, Gores GJ: Liver cell necrosis: Cellular mechanisms and clinical implications. Gastroenterology. 1995, 108: 252-275.PubMed
10.
go back to reference Aller MA, Arias JL, Nava MP, Arias J: Evolutive trophic phases of the systemic acute inflammatory response, oxygen use mechanisms and metamorphosis. Psicothema. 2004, 16: 369-372. Aller MA, Arias JL, Nava MP, Arias J: Evolutive trophic phases of the systemic acute inflammatory response, oxygen use mechanisms and metamorphosis. Psicothema. 2004, 16: 369-372.
11.
go back to reference Aller MA, Arias JL, Arias J: The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension. J Transl Med. 2007, 5: 44-PubMedCentralPubMed Aller MA, Arias JL, Arias J: The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension. J Transl Med. 2007, 5: 44-PubMedCentralPubMed
12.
go back to reference Yang JG, Rowe DJ, Dzwierzynski W, Yan YH, Zhang LL, Sanger J, Matloub HS: Pathophysiological process of traumatic vascular spasm in multiple crush injury. J Reconstr Microsurg. 2007, 23: 237-242. Yang JG, Rowe DJ, Dzwierzynski W, Yan YH, Zhang LL, Sanger J, Matloub HS: Pathophysiological process of traumatic vascular spasm in multiple crush injury. J Reconstr Microsurg. 2007, 23: 237-242.
13.
go back to reference Chien LC, Lu KJ, Wo CC, Shoemaker WC: Hemodynamic patterns preceding circulatory deterioration and death after trauma. J Trauma. 2007, 62: 928-932.PubMed Chien LC, Lu KJ, Wo CC, Shoemaker WC: Hemodynamic patterns preceding circulatory deterioration and death after trauma. J Trauma. 2007, 62: 928-932.PubMed
14.
go back to reference Garrison RN, Zakaria ER: Peritoneal resuscitation. Am J Surg. 2005, 190: 181-185.PubMed Garrison RN, Zakaria ER: Peritoneal resuscitation. Am J Surg. 2005, 190: 181-185.PubMed
15.
go back to reference Alanezi K, Alanzi F, Faidi S, Sprague S, Cadeddu M, Baillie F, Bowser D, McCallum A, Bhandari M: Survival rates for adult trauma patients who require cardiopulmonary resuscitation. CJEM. 2004, 6 (4): 263-265.PubMed Alanezi K, Alanzi F, Faidi S, Sprague S, Cadeddu M, Baillie F, Bowser D, McCallum A, Bhandari M: Survival rates for adult trauma patients who require cardiopulmonary resuscitation. CJEM. 2004, 6 (4): 263-265.PubMed
16.
go back to reference Willis CD, Cameron PA, Bernard SA, Fitzgerald M: Cardiopulmonary resuscitation after traumatic cardiac arrest is not always futile. Injury. 2006, 37: 448-454.PubMed Willis CD, Cameron PA, Bernard SA, Fitzgerald M: Cardiopulmonary resuscitation after traumatic cardiac arrest is not always futile. Injury. 2006, 37: 448-454.PubMed
17.
go back to reference SOS-KANTO study group: Cardiopulmonary resuscitation by bysbystanders with chest compression only (SOS-KANTO): an observational study. Lancet. 2007, 369: 920-926. SOS-KANTO study group: Cardiopulmonary resuscitation by bysbystanders with chest compression only (SOS-KANTO): an observational study. Lancet. 2007, 369: 920-926.
18.
go back to reference Hopson LR, Hirsh E, Delgado J, Domeier RM, McSwain NE, Krohmer J: Guidelines for withholding or termination of resuscitation in prehospital traumatic cardiopulmonary arrest: joint position statement of the national association of EMS physicians and the american college of surgeons committee on trauma. J Am Coll Surg. 2003, 196: 106-112.PubMed Hopson LR, Hirsh E, Delgado J, Domeier RM, McSwain NE, Krohmer J: Guidelines for withholding or termination of resuscitation in prehospital traumatic cardiopulmonary arrest: joint position statement of the national association of EMS physicians and the american college of surgeons committee on trauma. J Am Coll Surg. 2003, 196: 106-112.PubMed
19.
go back to reference Gentilello LM, Pierson DJ: Trauma critical care. Am J Respir Crit Care Med. 2001, 163: 604-607.PubMed Gentilello LM, Pierson DJ: Trauma critical care. Am J Respir Crit Care Med. 2001, 163: 604-607.PubMed
20.
go back to reference Moore FA, McKinley BA, Moore EE: The next generation in shock resuscitation. Lancet. 2004, 363: 1988-1996.PubMed Moore FA, McKinley BA, Moore EE: The next generation in shock resuscitation. Lancet. 2004, 363: 1988-1996.PubMed
21.
go back to reference Ho AMH, Karmakar MK, Dion PW: Are we giving enough coagulation factors during major trauma resuscitation?. Am J Surg. 2005, 190: 479-484.PubMed Ho AMH, Karmakar MK, Dion PW: Are we giving enough coagulation factors during major trauma resuscitation?. Am J Surg. 2005, 190: 479-484.PubMed
22.
go back to reference Weisfeldt ML, Becker LB: Resuscitation after cardiac arrest: A 3-phase time-sensitive model. JAMA. 2002, 288: 3035-3038.PubMed Weisfeldt ML, Becker LB: Resuscitation after cardiac arrest: A 3-phase time-sensitive model. JAMA. 2002, 288: 3035-3038.PubMed
23.
go back to reference Ali BA, Zafari AM: Cardiopulmonary resuscitation and emergency cardiovascular care: Review of the current guidelines. Ann Intern Med. 2007, 147: 171-179.PubMed Ali BA, Zafari AM: Cardiopulmonary resuscitation and emergency cardiovascular care: Review of the current guidelines. Ann Intern Med. 2007, 147: 171-179.PubMed
24.
go back to reference Pace MC, Mazzariello L, Passavanti MB, Sansone P, Barbarisi M, Aurillo C: Neurobiology of pain. J Cell Physiol. 2006, 209: 8-12.PubMed Pace MC, Mazzariello L, Passavanti MB, Sansone P, Barbarisi M, Aurillo C: Neurobiology of pain. J Cell Physiol. 2006, 209: 8-12.PubMed
25.
26.
go back to reference McMahon SB, Cafferty WBJ, Marchand F: Immune and glial cell factors as pain mediators and modulators. Exp Neurol. 2005, 192: 444-462.PubMed McMahon SB, Cafferty WBJ, Marchand F: Immune and glial cell factors as pain mediators and modulators. Exp Neurol. 2005, 192: 444-462.PubMed
27.
go back to reference Rittner HL, Brack A: Chemokines and pain. Curr Opin Investig Drugs. 2006, 7: 643-646.PubMed Rittner HL, Brack A: Chemokines and pain. Curr Opin Investig Drugs. 2006, 7: 643-646.PubMed
28.
go back to reference Pezet S, McMahon SB: Neurotrophins: Mediators and modulators of pain. Ann Rev Neurosci. 2006, 29: 507-538.PubMed Pezet S, McMahon SB: Neurotrophins: Mediators and modulators of pain. Ann Rev Neurosci. 2006, 29: 507-538.PubMed
29.
go back to reference McEwen BS: Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiol Rev. 2007, 87: 873-904.PubMed McEwen BS: Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiol Rev. 2007, 87: 873-904.PubMed
30.
go back to reference Clarke RW, Harris J: The organization of motor responses to noxious stimuli. Brain Res Rev. 2004, 46: 163-172.PubMed Clarke RW, Harris J: The organization of motor responses to noxious stimuli. Brain Res Rev. 2004, 46: 163-172.PubMed
31.
go back to reference Schmidt R, McDonagh AF: The enzymatic formation of bilirubin. Ann NY Acad Sci. 1975, 244: 533-552. Schmidt R, McDonagh AF: The enzymatic formation of bilirubin. Ann NY Acad Sci. 1975, 244: 533-552.
32.
go back to reference Maines MD, Cohn J: Bile pigment formation by skin heme oxygenase: Studies on the response of the enzyme to heme compounds and tissue injury. J Exp Med. 1977, 145: 1054-1059.PubMed Maines MD, Cohn J: Bile pigment formation by skin heme oxygenase: Studies on the response of the enzyme to heme compounds and tissue injury. J Exp Med. 1977, 145: 1054-1059.PubMed
33.
go back to reference Furuyama K, Kaneko K, Vargas PD: Heme as a magnificient molecule with multiple missions: Heme determines its own fate and governs cellular homeostasis. Tohoku J Exp Med. 2007, 213: 1-16.PubMed Furuyama K, Kaneko K, Vargas PD: Heme as a magnificient molecule with multiple missions: Heme determines its own fate and governs cellular homeostasis. Tohoku J Exp Med. 2007, 213: 1-16.PubMed
34.
go back to reference Otterbein LE, Soares MP, Yamashita K, Bach FH: Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003, 24: 449-455.PubMed Otterbein LE, Soares MP, Yamashita K, Bach FH: Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003, 24: 449-455.PubMed
35.
go back to reference Tang LM, Wang YP, Wang K, Pu LY, Zhang F, Li XC, Kong LB, Sun BC, Li GQ, Wang XH: Exogenous biliverdin ameoliorates ischemia-reperfusion injury in small-for-size rat liver grafts. Transplant Proc. 2007, 39: 1338-1344.PubMed Tang LM, Wang YP, Wang K, Pu LY, Zhang F, Li XC, Kong LB, Sun BC, Li GQ, Wang XH: Exogenous biliverdin ameoliorates ischemia-reperfusion injury in small-for-size rat liver grafts. Transplant Proc. 2007, 39: 1338-1344.PubMed
36.
go back to reference Freitas A, Alves-Filho JC, Secco DD, Neto AF, Ferrerira SH, Barja-Fidalgo C, Cunha FQ: Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation. Br J Pharmacol. 2006, 149: 345-354.PubMedCentralPubMed Freitas A, Alves-Filho JC, Secco DD, Neto AF, Ferrerira SH, Barja-Fidalgo C, Cunha FQ: Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation. Br J Pharmacol. 2006, 149: 345-354.PubMedCentralPubMed
37.
go back to reference Seta F, Bellner L, Rezzani R, Regan RF, Dunn MW, Abraham NG, Gronert K, Laniado-Schwartzman M: Heme oxygenase-2 is a critical determinant for execution of an acute inflammatory and reparative response. Am J Pathol. 2006, 169: 1612-1623.PubMedCentralPubMed Seta F, Bellner L, Rezzani R, Regan RF, Dunn MW, Abraham NG, Gronert K, Laniado-Schwartzman M: Heme oxygenase-2 is a critical determinant for execution of an acute inflammatory and reparative response. Am J Pathol. 2006, 169: 1612-1623.PubMedCentralPubMed
38.
go back to reference McCoubrey WKJr, Huang TJ, Maines MD: Isolation and characterization of a cDNA from the rat brain that encodes hemeprotein heme oxygenase-3. Eur J Biochem. 1997, 247: 725-732.PubMed McCoubrey WKJr, Huang TJ, Maines MD: Isolation and characterization of a cDNA from the rat brain that encodes hemeprotein heme oxygenase-3. Eur J Biochem. 1997, 247: 725-732.PubMed
39.
go back to reference Ding Y, Zhang Y-Z, Furuyama K, Ogawa K, Igarashi K, Shibahara S: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines. FEBS J. 2006, 273: 5333-5346.PubMed Ding Y, Zhang Y-Z, Furuyama K, Ogawa K, Igarashi K, Shibahara S: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines. FEBS J. 2006, 273: 5333-5346.PubMed
40.
go back to reference Orlinsky M, Shoemaker W, Reis ED, Kerstein MD: Current controversies in shock and resuscitation. Surg Clin North Am. 2001, 81: 1217-1262.PubMed Orlinsky M, Shoemaker W, Reis ED, Kerstein MD: Current controversies in shock and resuscitation. Surg Clin North Am. 2001, 81: 1217-1262.PubMed
41.
go back to reference Keel M, Trentz O: Pathophysiology of polytrauma. Injury. 2005, 36: 691-709.PubMed Keel M, Trentz O: Pathophysiology of polytrauma. Injury. 2005, 36: 691-709.PubMed
42.
go back to reference Martin L, Khalil H: How much reduced hemoglobin is necessary to generate central cyanosis?. Chest. 1990, 97: 182-185.PubMed Martin L, Khalil H: How much reduced hemoglobin is necessary to generate central cyanosis?. Chest. 1990, 97: 182-185.PubMed
43.
go back to reference Lundsgaard C, Van Sylke DD: The Quantitative Influences of Certain Factors Involved in the Production of Cyanosis. Proc Natl Acad Sci USA. 1922, 8: 280-282.PubMedCentralPubMed Lundsgaard C, Van Sylke DD: The Quantitative Influences of Certain Factors Involved in the Production of Cyanosis. Proc Natl Acad Sci USA. 1922, 8: 280-282.PubMedCentralPubMed
44.
go back to reference Maines MD: Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways. Antioxid Redox Signal. 2007, 9: 1-9. Maines MD: Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways. Antioxid Redox Signal. 2007, 9: 1-9.
45.
go back to reference Kohchi T, Mukougawa K, Frankenberg N, Masuda M, Yokota A, Lagarias JC: The arabidopsis HYE gene encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase. Plant Cell. 2001, 13: 425-436.PubMedCentralPubMed Kohchi T, Mukougawa K, Frankenberg N, Masuda M, Yokota A, Lagarias JC: The arabidopsis HYE gene encodes phytochromobilin synthase, a ferredoxin-dependent biliverdin reductase. Plant Cell. 2001, 13: 425-436.PubMedCentralPubMed
46.
go back to reference Pachori AS, Smith A, McDonald P, Zhang L, Dzau VJ, Melo LG: Heme-oxygenase-1 induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with Pi3k/AKT pathway. J Mol Cell Cardiol. 2007, 43: 580-592.PubMedCentralPubMed Pachori AS, Smith A, McDonald P, Zhang L, Dzau VJ, Melo LG: Heme-oxygenase-1 induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with Pi3k/AKT pathway. J Mol Cell Cardiol. 2007, 43: 580-592.PubMedCentralPubMed
47.
go back to reference Vitek L, Schwertner HA: The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases. Adv Clin Chem. 2007, 43: 1-57.PubMed Vitek L, Schwertner HA: The heme catabolic pathway and its protective effects on oxidative stress-mediated diseases. Adv Clin Chem. 2007, 43: 1-57.PubMed
48.
go back to reference Ollinger R, Wang H, Yamashita K, Wegiel B, Thomas M, Margreiter R, Bach FH: Therapeutic applications of bilirubin and biliverdin in transplantation. Antioxid Redox Signal. 2007, 9: 2175-2185.PubMed Ollinger R, Wang H, Yamashita K, Wegiel B, Thomas M, Margreiter R, Bach FH: Therapeutic applications of bilirubin and biliverdin in transplantation. Antioxid Redox Signal. 2007, 9: 2175-2185.PubMed
49.
go back to reference Bulmer AC, Ried K, Blanchfield JT, Wagner KH: The anti-mutagenic properties of bile pigments. Mutat Res. 2008, 658: 28-41.PubMed Bulmer AC, Ried K, Blanchfield JT, Wagner KH: The anti-mutagenic properties of bile pigments. Mutat Res. 2008, 658: 28-41.PubMed
51.
go back to reference Monaco JL, Lawrence WT: Acute wound healing. An overview. Clin Plastic Surg. 2003, 30: 1-12. Monaco JL, Lawrence WT: Acute wound healing. An overview. Clin Plastic Surg. 2003, 30: 1-12.
52.
go back to reference Sherwood ER, Toliver-Kinsky T: Mechanisms of inflammatory response. Dest Pract Res Clin Anesth. 2004, 18: 385-405. Sherwood ER, Toliver-Kinsky T: Mechanisms of inflammatory response. Dest Pract Res Clin Anesth. 2004, 18: 385-405.
53.
go back to reference Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HM, Bastia NJF, Fierer J, Nizet V: Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med. 2005, 202 (2): 209-215.PubMedCentralPubMed Liu GY, Essex A, Buchanan JT, Datta V, Hoffman HM, Bastia NJF, Fierer J, Nizet V: Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med. 2005, 202 (2): 209-215.PubMedCentralPubMed
54.
go back to reference Deitch EA: Infection in the compromised host. Surgical Infections. Surg Clin North Am. Edited by: Howard RJ. 1988, 68: 181-197. Deitch EA: Infection in the compromised host. Surgical Infections. Surg Clin North Am. Edited by: Howard RJ. 1988, 68: 181-197.
55.
go back to reference Ohkusu K: Cost-effective and rapid presumptive identification of gram-negative bacilli in routine urine, pus and stool cultures: evaluation of the use of CHRO Magar orientation medium in conjuntion with simple biochemical tests. J Clin Microbiol. 2000, 38: 4586-4592.PubMedCentralPubMed Ohkusu K: Cost-effective and rapid presumptive identification of gram-negative bacilli in routine urine, pus and stool cultures: evaluation of the use of CHRO Magar orientation medium in conjuntion with simple biochemical tests. J Clin Microbiol. 2000, 38: 4586-4592.PubMedCentralPubMed
56.
go back to reference Hau T, Haaga JR, Aeder MI: Pathophysiooogy, diagnosis and treatment of abdominal abscesses. Curr Probl Surg. 1984, 21: 1-82.PubMed Hau T, Haaga JR, Aeder MI: Pathophysiooogy, diagnosis and treatment of abdominal abscesses. Curr Probl Surg. 1984, 21: 1-82.PubMed
57.
go back to reference Iwatsuki K, Yamasaki O, Morizane S, Oono T: Staphylococcus cutaneous infections: Invasión, evasión and aggresion. J Dermatol Sci. 2006, 42: 203-214.PubMed Iwatsuki K, Yamasaki O, Morizane S, Oono T: Staphylococcus cutaneous infections: Invasión, evasión and aggresion. J Dermatol Sci. 2006, 42: 203-214.PubMed
58.
go back to reference Loo WTY, Sasano H, Chow LWC: Pro-inflammatory cytokine, matrix metalloproteinases and TIMP-1 are involved in wound healing after mastectomy in invasive breast cancer patients. Biomed Pharmacother. 2007, 61: 548-552.PubMed Loo WTY, Sasano H, Chow LWC: Pro-inflammatory cytokine, matrix metalloproteinases and TIMP-1 are involved in wound healing after mastectomy in invasive breast cancer patients. Biomed Pharmacother. 2007, 61: 548-552.PubMed
59.
go back to reference Nerusu KC, Warner RL, Bhagavathula N, McClintock SD, Johnson KJ, Varani J: Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury. Exp Mol Pathol. 2007, 83: 169-176.PubMedCentralPubMed Nerusu KC, Warner RL, Bhagavathula N, McClintock SD, Johnson KJ, Varani J: Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury. Exp Mol Pathol. 2007, 83: 169-176.PubMedCentralPubMed
60.
go back to reference Gruys E, Toussaint MJM, Niewold TA, Koopmans SJ: Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci. 2005, 6B: 1045-1056. Gruys E, Toussaint MJM, Niewold TA, Koopmans SJ: Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci. 2005, 6B: 1045-1056.
61.
go back to reference Qin X: Inactivation of digestive proteases by deconjugated bilirubin: the possible evolutionary driving force for bilirubin or biliverdin predominance in animals. Gut. 2007, 56: 1641-1642.PubMedCentralPubMed Qin X: Inactivation of digestive proteases by deconjugated bilirubin: the possible evolutionary driving force for bilirubin or biliverdin predominance in animals. Gut. 2007, 56: 1641-1642.PubMedCentralPubMed
62.
go back to reference Qin XF: Impaired inactivation of digestive proteases by deconjugated bilirubin: the possible mechanism for inflammatory bowel disease. Med Hypotheses. 2002, 59: 159-163.PubMed Qin XF: Impaired inactivation of digestive proteases by deconjugated bilirubin: the possible mechanism for inflammatory bowel disease. Med Hypotheses. 2002, 59: 159-163.PubMed
63.
go back to reference Ascenzi P, Bocedi A, Visca P, Altruda F, Tolosano E, Beringhelli T, Fasano M: Hemoglobin and heme scavenging. IUBMB Life. 2005, 57: 749-759.PubMed Ascenzi P, Bocedi A, Visca P, Altruda F, Tolosano E, Beringhelli T, Fasano M: Hemoglobin and heme scavenging. IUBMB Life. 2005, 57: 749-759.PubMed
64.
go back to reference Reniere ML, Torres VJ, Skaar EP: Intracellular metalloporphyrin metabolism in staphylococcus aureus. Biometals. 2007, 20: 333-345.PubMed Reniere ML, Torres VJ, Skaar EP: Intracellular metalloporphyrin metabolism in staphylococcus aureus. Biometals. 2007, 20: 333-345.PubMed
65.
go back to reference Mastoraki A, Karatzis E, Mastoraki S, Kriaras I, Sfirakis P, Geroulands S: Postoperative jaundice after cardiac surgery. Hepatobiliary Pancreat Dis Int. 2007, 6: 383-387.PubMed Mastoraki A, Karatzis E, Mastoraki S, Kriaras I, Sfirakis P, Geroulands S: Postoperative jaundice after cardiac surgery. Hepatobiliary Pancreat Dis Int. 2007, 6: 383-387.PubMed
66.
go back to reference Chou FF, Sheen-Chen SM, Chen YS, Chen MC, Chen FC, Tai DI: Prognostic factor for pyogenic abscess of the liver. J Am Coll Surg. 1994, 179: 727-732.PubMed Chou FF, Sheen-Chen SM, Chen YS, Chen MC, Chen FC, Tai DI: Prognostic factor for pyogenic abscess of the liver. J Am Coll Surg. 1994, 179: 727-732.PubMed
67.
go back to reference Maisels MJ: What's in a name? Physiologic and pathologic jaundice: The conundrum of defining normal bilirubin levels in the newborn. Pediatrics. 2006, 118: 805-807.PubMed Maisels MJ: What's in a name? Physiologic and pathologic jaundice: The conundrum of defining normal bilirubin levels in the newborn. Pediatrics. 2006, 118: 805-807.PubMed
68.
go back to reference Zanardo V, Golin R, Amato M, Trevisanuto D, Favaro F, Faggian D, Plebani M: Cytokines in human colostrum and neonatal jaundice. Pediatr Res. 2007, 62 (2): 191-194.PubMed Zanardo V, Golin R, Amato M, Trevisanuto D, Favaro F, Faggian D, Plebani M: Cytokines in human colostrum and neonatal jaundice. Pediatr Res. 2007, 62 (2): 191-194.PubMed
69.
go back to reference Kadl A, Pontiller J, Exner M, Leitinger N: Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia. Shock. 2007, 28: 582-588.PubMed Kadl A, Pontiller J, Exner M, Leitinger N: Single bolus injection of bilirubin improves the clinical outcome in a mouse model of endotoxemia. Shock. 2007, 28: 582-588.PubMed
70.
go back to reference Carrico CJ, Meakins JL, Marshall JC, Fry D, Maier RV: Multiple-organ-failure syndrome. Arch Surg. 1986, 121: 196-208.PubMed Carrico CJ, Meakins JL, Marshall JC, Fry D, Maier RV: Multiple-organ-failure syndrome. Arch Surg. 1986, 121: 196-208.PubMed
71.
go back to reference Marshall JC, Christou NV, Meakins JL: The gastrointestinal tract. The "undrained abscess" of multiple organ failure. Ann Surg. 1993, 218: 111-119.PubMedCentralPubMed Marshall JC, Christou NV, Meakins JL: The gastrointestinal tract. The "undrained abscess" of multiple organ failure. Ann Surg. 1993, 218: 111-119.PubMedCentralPubMed
72.
go back to reference Gatt M, Reddy BS, MacFie J: Bacterial translocation in the critical ill. Evidence and methods of prevention. Aliment Pharmacol Ther. 2007, 25: 741-757.PubMed Gatt M, Reddy BS, MacFie J: Bacterial translocation in the critical ill. Evidence and methods of prevention. Aliment Pharmacol Ther. 2007, 25: 741-757.PubMed
73.
go back to reference Cheadle WG, Turina M: Infection and organ failure in the surgical patient: a tribute to seminal contributions by Hiram C. Pok, Jr, MD. Am J Surg. 2005, 190: 173-177.PubMed Cheadle WG, Turina M: Infection and organ failure in the surgical patient: a tribute to seminal contributions by Hiram C. Pok, Jr, MD. Am J Surg. 2005, 190: 173-177.PubMed
74.
go back to reference Luyer MD, Buurman WA, Hadfoune M, Wolfs T, Van't Veer C, Jacobs JA, Dejong CH, Greve JWM: Exposure to bacterial DNA before hemorrhagic shock strongly aggravates systemic inflammation and gut barrier loss via an IFN-γ-dependent route. Ann Surg. 2007, 245: 795-802.PubMedCentralPubMed Luyer MD, Buurman WA, Hadfoune M, Wolfs T, Van't Veer C, Jacobs JA, Dejong CH, Greve JWM: Exposure to bacterial DNA before hemorrhagic shock strongly aggravates systemic inflammation and gut barrier loss via an IFN-γ-dependent route. Ann Surg. 2007, 245: 795-802.PubMedCentralPubMed
75.
go back to reference Ulloa L, Tracey KJ: The "cytokine profile": a code for sepsis. Trends Mol Med. 2005, 11: 56-63.PubMed Ulloa L, Tracey KJ: The "cytokine profile": a code for sepsis. Trends Mol Med. 2005, 11: 56-63.PubMed
76.
go back to reference Moseley RH: Sepsis and cholestasis. Clin Liver Dis. 1999, 3: 465-475.PubMed Moseley RH: Sepsis and cholestasis. Clin Liver Dis. 1999, 3: 465-475.PubMed
77.
go back to reference Marrero J, Martinez FJ, Hyzy R: Advances in critical care hepatology. Am J Respir Crit Care Med. 2003, 168: 1421-1426.PubMed Marrero J, Martinez FJ, Hyzy R: Advances in critical care hepatology. Am J Respir Crit Care Med. 2003, 168: 1421-1426.PubMed
78.
go back to reference Von Hundelshausen P, Weber C: Platelets as immune cells. Bridging inflammation and cardiovascular disease. Circ Res. 2007, 100: 27-40.PubMed Von Hundelshausen P, Weber C: Platelets as immune cells. Bridging inflammation and cardiovascular disease. Circ Res. 2007, 100: 27-40.PubMed
79.
go back to reference Oberyszyn TM: Inflammation and wound healing. Front Biosci. 2007, 12: 2993-2999.PubMed Oberyszyn TM: Inflammation and wound healing. Front Biosci. 2007, 12: 2993-2999.PubMed
80.
go back to reference Borregaard N, Sørensen OE, Theilgaard-Mönch K: Neutrophil granules: a library of innate immunity proteins. Trends Immunol. 2007, 28: 340-345.PubMed Borregaard N, Sørensen OE, Theilgaard-Mönch K: Neutrophil granules: a library of innate immunity proteins. Trends Immunol. 2007, 28: 340-345.PubMed
81.
go back to reference Heideman SM, Glibetic M: Comparison of the systemic and pulmonary inflammatory response to endotoxin of neutropenic and non-neutropenic rats. J Inflamm (Lond). 2007, 4: 7- Heideman SM, Glibetic M: Comparison of the systemic and pulmonary inflammatory response to endotoxin of neutropenic and non-neutropenic rats. J Inflamm (Lond). 2007, 4: 7-
82.
go back to reference Duffield JS: The inflammatory macrophage: a story of Jekyll and Hyde. Clin Sci. 2003, 104: 27-38.PubMed Duffield JS: The inflammatory macrophage: a story of Jekyll and Hyde. Clin Sci. 2003, 104: 27-38.PubMed
83.
go back to reference Serhan CN, Savill J: Resolution of inflammaton: the beginning programs the end. Nature Immunol. 1005, 6: 1191-1197. Serhan CN, Savill J: Resolution of inflammaton: the beginning programs the end. Nature Immunol. 1005, 6: 1191-1197.
84.
go back to reference Meneghin A, Hogaboam GM: Infections disease, the innate immune response, and fibrosis. J Clin Invest. 2007, 117: 530-538.PubMedCentralPubMed Meneghin A, Hogaboam GM: Infections disease, the innate immune response, and fibrosis. J Clin Invest. 2007, 117: 530-538.PubMedCentralPubMed
85.
go back to reference Smith EM: Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis. Brain Behav Immun. 2007, 22: 3-14.PubMedCentralPubMed Smith EM: Neuropeptides as signal molecules in common with leukocytes and the hypothalamic-pituitary-adrenal axis. Brain Behav Immun. 2007, 22: 3-14.PubMedCentralPubMed
86.
go back to reference Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LAJ, Peretti M, Rossi AG, Wallace JL: Resolution of inflammation: state of the art, definitions and terms. FASEB J. 2007, 21: 325-332.PubMedCentralPubMed Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, O'Neill LAJ, Peretti M, Rossi AG, Wallace JL: Resolution of inflammation: state of the art, definitions and terms. FASEB J. 2007, 21: 325-332.PubMedCentralPubMed
87.
go back to reference Rajakariar R, Yaqoob MM, Gilroy DW: Cox-2 in inflammation and resolution. Mol Interv. 2006, 6: 199-207.PubMed Rajakariar R, Yaqoob MM, Gilroy DW: Cox-2 in inflammation and resolution. Mol Interv. 2006, 6: 199-207.PubMed
88.
go back to reference Sitkovsky MV: T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response. Trends Immunol. 2009, 30: 102-108.PubMed Sitkovsky MV: T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response. Trends Immunol. 2009, 30: 102-108.PubMed
89.
go back to reference Flavell SJ, Hou TZ, Lax S, Filer AD, Salmon M, Buckley CD: Fibroblasts as novel therapeutic targets in chronic inflammation. Br J Pharmacol. 2008, 153 (Suppl 1): S241-246.PubMedCentralPubMed Flavell SJ, Hou TZ, Lax S, Filer AD, Salmon M, Buckley CD: Fibroblasts as novel therapeutic targets in chronic inflammation. Br J Pharmacol. 2008, 153 (Suppl 1): S241-246.PubMedCentralPubMed
90.
go back to reference Parsonage G, Filer AD, Haworth O, Nash GB, Rainger GE, Salmon M, Buckley CD: A stromal address code defined by fibroblasts. Trends Immunol. 2005, 26: 150-156.PubMedCentralPubMed Parsonage G, Filer AD, Haworth O, Nash GB, Rainger GE, Salmon M, Buckley CD: A stromal address code defined by fibroblasts. Trends Immunol. 2005, 26: 150-156.PubMedCentralPubMed
91.
go back to reference Buckley CD, Pilling D, Lord JM, Akbar AN, Scheel-Toellner D, Salmon M: Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol. 2001, 22: 199-204.PubMed Buckley CD, Pilling D, Lord JM, Akbar AN, Scheel-Toellner D, Salmon M: Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol. 2001, 22: 199-204.PubMed
92.
go back to reference Changizi MA, Zhang Q, Shimojo S: Bare skin, blood and the evolution of primate colour vision. Biol Lett. 2006, 2: 217-221.PubMedCentralPubMed Changizi MA, Zhang Q, Shimojo S: Bare skin, blood and the evolution of primate colour vision. Biol Lett. 2006, 2: 217-221.PubMedCentralPubMed
93.
go back to reference Beard DA, Wu F, Cabrera ME, Dash RK: Modeling of cellular metabolism and microcirculatory transport. Microcirculation. 2008, 15: 777-793.PubMed Beard DA, Wu F, Cabrera ME, Dash RK: Modeling of cellular metabolism and microcirculatory transport. Microcirculation. 2008, 15: 777-793.PubMed
94.
go back to reference Madjdpour C, Heindl V, Spahn DR: Risks, benefits, alternatives and indications of allogenic blood transfusions. Minerva Anestesiol. 2006, 72: 283-298.PubMed Madjdpour C, Heindl V, Spahn DR: Risks, benefits, alternatives and indications of allogenic blood transfusions. Minerva Anestesiol. 2006, 72: 283-298.PubMed
95.
go back to reference Leow MKS: Configuration of the hemoglobin oxygen dissociation curve desmystified: a basic mathematical proof for medical and biological sciences undergraduates. Adv Physiol Educ. 2007, 31: 198-201.PubMed Leow MKS: Configuration of the hemoglobin oxygen dissociation curve desmystified: a basic mathematical proof for medical and biological sciences undergraduates. Adv Physiol Educ. 2007, 31: 198-201.PubMed
96.
go back to reference Ribatti D, Conconi MT, Nussdorfer GG: Nonclassic endogenous novel [corrected] regulators of angiogenesis. Pharmacol Rev. 2007, 59: 185-205.PubMed Ribatti D, Conconi MT, Nussdorfer GG: Nonclassic endogenous novel [corrected] regulators of angiogenesis. Pharmacol Rev. 2007, 59: 185-205.PubMed
97.
go back to reference El Alwani M, Wu BX, Obeid LM, Hannun YA: Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther. 2006, 112: 171-183.PubMed El Alwani M, Wu BX, Obeid LM, Hannun YA: Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol Ther. 2006, 112: 171-183.PubMed
98.
go back to reference Ariel A, Serhan CN: Resolvins and protectins in the termination program of acute inflammation. Trends Immunol. 2007, 28: 176-183.PubMed Ariel A, Serhan CN: Resolvins and protectins in the termination program of acute inflammation. Trends Immunol. 2007, 28: 176-183.PubMed
99.
go back to reference Yacoubian S, Serhan CN: New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases. Nat Clin Pract Rheumatol. 2007, 3: 570-579.PubMed Yacoubian S, Serhan CN: New endogenous anti-inflammatory and proresolving lipid mediators: implications for rheumatic diseases. Nat Clin Pract Rheumatol. 2007, 3: 570-579.PubMed
100.
go back to reference Clapp C, Aranda J, Gonzalez C, Jeziorski MC, Martinez de la Escalera G: Vasoinhibins: endogenous regulators of angiogenesis and vascular function. Trends Endocrinol Metabol. 2006, 17: 301-307. Clapp C, Aranda J, Gonzalez C, Jeziorski MC, Martinez de la Escalera G: Vasoinhibins: endogenous regulators of angiogenesis and vascular function. Trends Endocrinol Metabol. 2006, 17: 301-307.
101.
go back to reference Gurtner GC, Werner S, Barrandon Y, Longaker MT: Wound repair and regeneration. Nature. 2008, 453: 314-321.PubMed Gurtner GC, Werner S, Barrandon Y, Longaker MT: Wound repair and regeneration. Nature. 2008, 453: 314-321.PubMed
102.
go back to reference Burns JL, Mancoll JS, Phillips LG: Impairments to wound healing. Clin Plastic Surg. 2003, 30: 47-56. Burns JL, Mancoll JS, Phillips LG: Impairments to wound healing. Clin Plastic Surg. 2003, 30: 47-56.
103.
go back to reference Rahban SR, Garner WL: Fibroproliferative scars. Clin Plastic Surg. 2003, 30: 77-89. Rahban SR, Garner WL: Fibroproliferative scars. Clin Plastic Surg. 2003, 30: 77-89.
104.
go back to reference Arruda MA, Graça-Souza AV, Barja-Fidalgo C: Heme and innate immunity: a new insights for an old molecule. Mem Inst Oswaldo Cruz. 2005, 100: 799-803.PubMed Arruda MA, Graça-Souza AV, Barja-Fidalgo C: Heme and innate immunity: a new insights for an old molecule. Mem Inst Oswaldo Cruz. 2005, 100: 799-803.PubMed
105.
go back to reference Iredale JP: Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest. 2007, 117: 539-548.PubMedCentralPubMed Iredale JP: Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest. 2007, 117: 539-548.PubMedCentralPubMed
106.
go back to reference Berghe Van Den G: Neuroendocrine axis in critical illness. Curr Opin Endocrinol Diabetes. 2001, 8: 47-54. Berghe Van Den G: Neuroendocrine axis in critical illness. Curr Opin Endocrinol Diabetes. 2001, 8: 47-54.
107.
go back to reference Yasuhara S, Asai A, Sahani ND, Martín JA: Mitochondria, endoplasmic reticulum, and alternative pathways of cell death in critical illness. Crit Care Med. 2007, 35: S488-S495.PubMed Yasuhara S, Asai A, Sahani ND, Martín JA: Mitochondria, endoplasmic reticulum, and alternative pathways of cell death in critical illness. Crit Care Med. 2007, 35: S488-S495.PubMed
108.
go back to reference Kiang NY, Siefert J, Govindjee , Blankenship RE: Spectral signatures of photosynthesis. I. Review of earth organisms. Astrobiology. 2007, 7: 222-251.PubMed Kiang NY, Siefert J, Govindjee , Blankenship RE: Spectral signatures of photosynthesis. I. Review of earth organisms. Astrobiology. 2007, 7: 222-251.PubMed
109.
go back to reference Eckhardt U, Grimm B, Hörtensteiner S: Recent advances in chlorophyll biosynthesis and breakdown in higher plants. Plant Mol Biol. 2004, 56: 1-14.PubMed Eckhardt U, Grimm B, Hörtensteiner S: Recent advances in chlorophyll biosynthesis and breakdown in higher plants. Plant Mol Biol. 2004, 56: 1-14.PubMed
110.
go back to reference Tanaka A, Tanaka R: Chlorophyl metabolism. Curr Opin Plant Biol. 2006, 9: 248-255.PubMed Tanaka A, Tanaka R: Chlorophyl metabolism. Curr Opin Plant Biol. 2006, 9: 248-255.PubMed
111.
go back to reference Sasaki K, Watanabe M, Suda Y, Ishizuka A, Noparatnaraporn N: Applications of photosynthetic bacteria for medical fields. J Biosci Bioeng. 2005, 100: 481-488.PubMed Sasaki K, Watanabe M, Suda Y, Ishizuka A, Noparatnaraporn N: Applications of photosynthetic bacteria for medical fields. J Biosci Bioeng. 2005, 100: 481-488.PubMed
112.
go back to reference Latunde-Dada GO, Simpson RJ, McKie AT: Recent advances in mammalian haem transport. Trends Biochem Sci. 2006, 31: 182-188.PubMed Latunde-Dada GO, Simpson RJ, McKie AT: Recent advances in mammalian haem transport. Trends Biochem Sci. 2006, 31: 182-188.PubMed
113.
go back to reference Reedy CJ, Elvekrog MM, Gibney BR: Development of a heme protein structure-electrochemical function database. Nucleic Acids Res. 2008, 36: D307-D313.PubMedCentralPubMed Reedy CJ, Elvekrog MM, Gibney BR: Development of a heme protein structure-electrochemical function database. Nucleic Acids Res. 2008, 36: D307-D313.PubMedCentralPubMed
114.
go back to reference Tanaka R, Tanaka A: Tetrapyrrole biosynthesis in higher plants. Ann Rev Plant Biol. 2007, 58: 321-346. Tanaka R, Tanaka A: Tetrapyrrole biosynthesis in higher plants. Ann Rev Plant Biol. 2007, 58: 321-346.
115.
go back to reference Hosler JP, Ferguson-Miller S, Mills DA: Energy transduction: Proton transfer through the respiratory complexes. Ann Rev Biochem. 2006, 75: 165-187.PubMedCentralPubMed Hosler JP, Ferguson-Miller S, Mills DA: Energy transduction: Proton transfer through the respiratory complexes. Ann Rev Biochem. 2006, 75: 165-187.PubMedCentralPubMed
116.
go back to reference Kiang NY, Segura A, Tinetti G, Govindjee , Blankenship RE, Cohen M, Sieffert J, Crisp D, Meadows VS: Spectral signatures of photosynthesis. II. Coevolution with other stars and the atmosphere on extrasolar worlds. Astrobiology. 2007, 7: 252-274.PubMed Kiang NY, Segura A, Tinetti G, Govindjee , Blankenship RE, Cohen M, Sieffert J, Crisp D, Meadows VS: Spectral signatures of photosynthesis. II. Coevolution with other stars and the atmosphere on extrasolar worlds. Astrobiology. 2007, 7: 252-274.PubMed
117.
go back to reference Ramon y Cajal S: Patogenia de la inflamación. Discurso de Doctorado. 2007, Edición facsímil. Universidad de Zaragoza y Gobierno de Aragón. INO Reproducciones S.A. Zaragoza, 1-109. Ramon y Cajal S: Patogenia de la inflamación. Discurso de Doctorado. 2007, Edición facsímil. Universidad de Zaragoza y Gobierno de Aragón. INO Reproducciones S.A. Zaragoza, 1-109.
118.
go back to reference Aragoneses J, Fraisl P, Baes M, Carmeliet P: Oxygen sensors at the crossroad of metabolism. Cell Metabolism. 2009, 9: 11-22. Aragoneses J, Fraisl P, Baes M, Carmeliet P: Oxygen sensors at the crossroad of metabolism. Cell Metabolism. 2009, 9: 11-22.
119.
go back to reference Jackson RM, Ann HS, Oparil S: Hypoxia-induced oxygen tolerante:maintenance of endotelial metabolic function. Exp Lung Res. 1988, 14: 887-896.PubMed Jackson RM, Ann HS, Oparil S: Hypoxia-induced oxygen tolerante:maintenance of endotelial metabolic function. Exp Lung Res. 1988, 14: 887-896.PubMed
120.
go back to reference Raymond J, Segre D: The effect of oxygen on biochemical networks and the evolution of complex life. Science. 2006, 311: 1764-1767.PubMed Raymond J, Segre D: The effect of oxygen on biochemical networks and the evolution of complex life. Science. 2006, 311: 1764-1767.PubMed
121.
go back to reference Acquisti C, Kleffe J, Collins S: Oxygen content of transmembrane proteins over macroevolutionary time scales. Nature. 2007, 445: 47-52.PubMed Acquisti C, Kleffe J, Collins S: Oxygen content of transmembrane proteins over macroevolutionary time scales. Nature. 2007, 445: 47-52.PubMed
122.
go back to reference Porto BN, Alves LS, Fernandez PL, Dutra TP, Figueiredo RT, Graça-Souza AV, Bozza MT: Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristics of chemotactic receptors. J Biol Chem. 2007, 282: 24430-24436.PubMed Porto BN, Alves LS, Fernandez PL, Dutra TP, Figueiredo RT, Graça-Souza AV, Bozza MT: Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristics of chemotactic receptors. J Biol Chem. 2007, 282: 24430-24436.PubMed
123.
go back to reference Takahashi T, Shimizu H, Morimatsu H, Inoue K, Akagi R, Morita K, Sassa S: Heme oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation. Mini Rev Med Chem. 2007, 7: 745-753.PubMed Takahashi T, Shimizu H, Morimatsu H, Inoue K, Akagi R, Morita K, Sassa S: Heme oxygenase-1: a fundamental guardian against oxidative tissue injuries in acute inflammation. Mini Rev Med Chem. 2007, 7: 745-753.PubMed
124.
go back to reference Siegbahn PEM, Blomberg MRA: Energy diagrams and mechanism for proton pumping in cytochrome C oxidase. Biochem Biophys Acta. 2007, 1767: 1143-1156.PubMed Siegbahn PEM, Blomberg MRA: Energy diagrams and mechanism for proton pumping in cytochrome C oxidase. Biochem Biophys Acta. 2007, 1767: 1143-1156.PubMed
125.
go back to reference Battersby AR: Tetrapyrroles: the pigments of life. Nat Prod Rep. 2000, 17: 507-526.PubMed Battersby AR: Tetrapyrroles: the pigments of life. Nat Prod Rep. 2000, 17: 507-526.PubMed
126.
go back to reference Avisar YJ, Beale SI: Biosynthesis of tetrapyrrole pigment precursors. (Pyridoxal requirement of the aminotransferase step in the formation of γ-amino-levulinate from glutamate in extracts of chlorella vulgaris). Plant Physiol. 1989, 89: 852-859. Avisar YJ, Beale SI: Biosynthesis of tetrapyrrole pigment precursors. (Pyridoxal requirement of the aminotransferase step in the formation of γ-amino-levulinate from glutamate in extracts of chlorella vulgaris). Plant Physiol. 1989, 89: 852-859.
127.
go back to reference Ougham HJ, Morris P, Thomas H: The colors of autum leaves as symtoms of cellular recycling and defenses against environmental stresses. Curr Top Dev Biol. 2005, 66: 135-160.PubMed Ougham HJ, Morris P, Thomas H: The colors of autum leaves as symtoms of cellular recycling and defenses against environmental stresses. Curr Top Dev Biol. 2005, 66: 135-160.PubMed
128.
go back to reference Ogawa M, Tani K, Ochiai A, Yamaguchi N, Nasu M: Multicolour digital image analysis system for identification of bacteria and concurrent assessment of their respiratory activity. J Appl Microbiol. 2005, 98: 1101-1106.PubMed Ogawa M, Tani K, Ochiai A, Yamaguchi N, Nasu M: Multicolour digital image analysis system for identification of bacteria and concurrent assessment of their respiratory activity. J Appl Microbiol. 2005, 98: 1101-1106.PubMed
129.
go back to reference Rochfort S: Metabolomics reviewed: a new "omics" platform technology for systems biology and implications for natural products research. J Nat Prod. 2005, 68: 1813-1820.PubMed Rochfort S: Metabolomics reviewed: a new "omics" platform technology for systems biology and implications for natural products research. J Nat Prod. 2005, 68: 1813-1820.PubMed
130.
go back to reference Spratlin JL, Serkova NJ, Eckhardt SG: Clinical applications of metabolomics in oncology: a review. Clin Cancer Res. 2009, 15: 431-440.PubMedCentralPubMed Spratlin JL, Serkova NJ, Eckhardt SG: Clinical applications of metabolomics in oncology: a review. Clin Cancer Res. 2009, 15: 431-440.PubMedCentralPubMed
131.
go back to reference Pipirov Z, Bottrill AR, Svistunenko DA, Efimov I, Basran J, Mistry SC, Cooper CE, Raven EL: The reactivity of heme in biological systems: Autocatalytic formation of both tyrosine-heme and truptophan-heme covalent links in a single protein architecture. Biochemistry. 2007, 46: 13269-13278. Pipirov Z, Bottrill AR, Svistunenko DA, Efimov I, Basran J, Mistry SC, Cooper CE, Raven EL: The reactivity of heme in biological systems: Autocatalytic formation of both tyrosine-heme and truptophan-heme covalent links in a single protein architecture. Biochemistry. 2007, 46: 13269-13278.
132.
go back to reference De Matteis F, Lord GA: Desferrioxamine dehydrogenates bilirubin in two stages, leading to a 1:1 red-coloured adduct characterization of the products by high-performance liquid cromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2008, 22: 4055-4065.PubMed De Matteis F, Lord GA: Desferrioxamine dehydrogenates bilirubin in two stages, leading to a 1:1 red-coloured adduct characterization of the products by high-performance liquid cromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2008, 22: 4055-4065.PubMed
133.
go back to reference Aller MA, Arias JL, Arias JI, Sanchez-Patan F, Arias J: The inflammatory response recapitulates phylogeny through trophic mechanisms to the injured tissue. Med Hypotheses. 2007, 68: 202-209.PubMed Aller MA, Arias JL, Arias JI, Sanchez-Patan F, Arias J: The inflammatory response recapitulates phylogeny through trophic mechanisms to the injured tissue. Med Hypotheses. 2007, 68: 202-209.PubMed
134.
go back to reference Suo Z, Avci R, Schweitzer MH, Deliorman M: Porphyrin as an ideal biomarker in the search for extraterrestrial life. Astrobiology. 2007, 7: 605-615.PubMed Suo Z, Avci R, Schweitzer MH, Deliorman M: Porphyrin as an ideal biomarker in the search for extraterrestrial life. Astrobiology. 2007, 7: 605-615.PubMed
Metadata
Title
Surgical inflammation: a pathophysiological rainbow
Authors
Jose-Ignacio Arias
María-Angeles Aller
Jaime Arias
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Journal of Translational Medicine / Issue 1/2009
Electronic ISSN: 1479-5876
DOI
https://doi.org/10.1186/1479-5876-7-19

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