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Open Access 01-04-2010 | Research Article

Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderly

Authors: Liana G. Apostolova, Paul M. Thompson, Steve A. Rogers, Ivo D. Dinov, Charleen Zoumalan, Calen A. Steiner, Erin Siu, Amity E. Green, Gary W. Small, Arthur W. Toga, Jeffrey L. Cummings, Michael E. Phelps, Daniel H. Silverman

Published in: Molecular Imaging and Biology | Issue 2/2010

Abstract

Purpose

The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly.

Procedures

Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 ± 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-d-glucose (FDG)-PET scan (interval 21.7 ± 3.7 months), baseline structural 3T magnetic resonance (MR) imaging, and apolipoprotein E4 genotyping. Cortical PET metabolic changes were analyzed in 3-D using the cortical pattern matching technique.

Results

Baseline vs. follow-up whole-group comparison revealed significant metabolic decline bilaterally in the posterior temporal, parietal, and occipital lobes and the left lateral frontal cortex. The declining group demonstrated 10–15% decline in bilateral posterior cingulate/precuneus, posterior temporal, parietal, and occipital cortices. The cognitively stable group showed 2.5–5% similarly distributed decline. ApoE4-positive individuals underwent 5–15% metabolic decline in the posterior association cortices.

Conclusions

Using 3-D surface-based MR-guided FDG-PET mapping, significant metabolic changes were seen in five posterior and the left lateral frontal regions. The changes were more pronounced for the declining relative to the cognitively stable group.

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Title: Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderly
Authors: Liana G. Apostolova
Paul M. Thompson
Steve A. Rogers
Ivo D. Dinov
Charleen Zoumalan
Calen A. Steiner
Erin Siu
Amity E. Green
Gary W. Small
Arthur W. Toga
Jeffrey L. Cummings
Michael E. Phelps
Daniel H. Silverman
Publication date: 01-04-2010
Publisher: Springer-Verlag
Published in: Molecular Imaging and Biology / Issue 2/2010
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-009-0247-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Surface Feature-Guided Mapping of Cerebral Metabolic Changes in Cognitively Normal and Mildly Impaired Elderly

Abstract

Purpose

Procedures

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Procedures

Results

Conclusions

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